protein

LAMP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1589Connections

1Hypotheses

8Analyses

50Outgoing

50Incoming

1Experiments

10Debates

Summary

Detailed page for LAMP1 Protein, a major lysosomal membrane glycoprotein involved in autophagy and neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	LAMP1
Full Name	Lysosomal Associated Membrane Protein 1
Chromosome	13q34
Protein Family	LAMP family
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Protects lysosomal membrane proteins from proteolytic degradation
Mechanism of Action	Direct LAMP1 modulators enhance lysosomal membrane trafficking and autophagy flux, while indirect pathway drugs alter lysosomal pH and autophagosome-lysosome fusion dynamics to modulate LAMP1-mediated cellular clearance mechanisms.
Primary Expression	Ubiquitous, highest in brain
Druggability	Low (0.43)
Clinical Stage	Phase I
Molecular Weight	120 kDa
Amino Acids	417 aa
Pathways	mTOR
UniProt ID	P11279
GeneCards	LAMP1
Human Protein Atlas	LAMP1
Associated Diseases	AD, ADH, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	COENZYME Q10, rapamycin, RAPAMYCIN
Interactions	ABCA1, ACHE, ACLY, ACTB, Actin, AD
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Lysosomal Positioning Dynamics Modulation
KG Connections	1589 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — LAMP1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5GV0 — X-ray / Cryo-EM

🔮 AI Predicted Structure

P11279 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    LAMP1(["LAMP1"])
    TMEM175(["TMEM175"])
    Lysosomal_pH_Homeostasis("Lysosomal pH Homeostasis")
    h_b295a9dd["h-b295a9dd"]
    SQSTM1(["SQSTM1"])
    Lysosomal_Acidification("Lysosomal Acidification")
    Lysosomal_Degradation("Lysosomal Degradation")
    SLAMF7(["SLAMF7"])
    Autophagy["Autophagy"]
    AUTOPHAGY(["AUTOPHAGY"])
    Parkinson["Parkinson"]
    Als["Als"]
    Tumor["Tumor"]

    LAMP1 -->|"interacts with"| TMEM175
    LAMP1 -.->|"inhibits"| TMEM175
    LAMP1 -->|"regulates"| Lysosomal_pH_Homeostasis
    h_b295a9dd -->|"therapeutic target"| LAMP1
    SQSTM1 -->|"co-localizes"| LAMP1
    h_b295a9dd -->|"targets gene"| LAMP1
    LAMP1 -->|"associated with"| Lysosomal_Acidification
    LAMP1 -->|"involved in"| Lysosomal_Degradation
    SLAMF7 -->|"activates"| LAMP1
    h_b295a9dd -->|"targets"| LAMP1
    LAMP1 -->|"activates"| Autophagy
    LAMP1 -->|"associated with"| AUTOPHAGY
    LAMP1 -->|"associated with"| Parkinson
    LAMP1 -->|"activates"| Als
    LAMP1 -->|"associated with"| Tumor

    style LAMP1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (910)

Target	Relation	Type	Str
lysosomal_membrane	stabilizes	cellular_component	0.00
RAPAMYCIN	activates	drug	0.95
Autophagy	associated_with	process	0.95
TMEM175	interacts_with	protein	0.95
Lysosomes	component_of	organelle	0.95
TMEM175	inhibits	protein	0.95
Lysosomal Ph Homeostasis	regulates	process	0.95
Lysosome Biogenesis	involved_in	process	0.95
neural stem cells	activates	cell_type	0.90
Lysosomal Acidification	associated_with	process	0.90
Lysosomal pH Homeostasis	regulates	process	0.90
Parkinson'S Disease	involved_in	disease	0.85
Parkinson'S Disease	risk_factor_for	disease	0.85
lysosomal hydrolytic function	promotes	process	0.85
MCOLN1	associated_with	gene	0.80
RNA	activates	gene	0.80
lysosomal membrane integrity	associated_with	process	0.80
oxidative stress response	participates_in	pathway	0.80
neural stem cells	regulates	cell_type	0.80
Lysosomal Degradation	associated_with	process	0.80
Autophagy	activates	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
Parkinson's Disease	associated_with	disease	0.75
neurodegeneration	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
Als	regulates	disease	0.75
Als	activates	disease	0.75
Neurodegeneration	associated_with	disease	0.75
microglia	expressed_in	cell_type	0.75
Tumor	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
OPTN	inhibits	gene	0.70
PINK1	interacts_with	gene	0.70
LRRK2	activates	gene	0.70
RAGE	activates	gene	0.70
LRRK2	associated_with	gene	0.70
PYCARD	activates	gene	0.70
PSEN2	interacts_with	gene	0.70
PSEN1	interacts_with	gene	0.70
TFEB	targets	gene	0.70
LRRK2	interacts_with	gene	0.70
NFKB	targets	gene	0.70
XIAP	activates	gene	0.70
PSEN2	activates	gene	0.70
STING	regulates	gene	0.70
NRF2	targets	gene	0.70
VPS35	activates	gene	0.70
OLIGODENDROCYTES	activates	cell_type	0.70
TAU	activates	gene	0.70
SOD2	activates	gene	0.70

Incoming (679)

Source	Relation	Type	Str
rapamycin	targets	drug	0.90
SQSTM1	associated_with	gene	0.90
h-b295a9dd	targets	hypothesis	0.90
SLAMF7	activates	gene	0.80
ATG	activates	gene	0.80
HTT	interacts_with	gene	0.70
APOE	activates	gene	0.70
BMP	interacts_with	gene	0.70
FOXP3	interacts_with	gene	0.70
FRONTOTEMPORAL DEMENTIA	inhibits	disease	0.70
BDNF	interacts_with	gene	0.70
ATG7	regulates	gene	0.70
ATG5	regulates	gene	0.70
CGAS	interacts_with	gene	0.70
ATG5	inhibits	gene	0.70
AIF1	activates	gene	0.70
BACE1	degrades	gene	0.70
ACHE	activates	gene	0.70
APP	degrades	gene	0.70
ASTROCYTE	degrades	cell_type	0.70
CNP	activates	gene	0.70
CSF1R	activates	gene	0.70
ATG7	inhibits	gene	0.70
IBA1	degrades	gene	0.70
AIF1	degrades	gene	0.70
AIF1	regulates	gene	0.70
CX3CR1	activates	gene	0.70
GFAP	associated_with	gene	0.70
CHOLINERGIC	interacts_with	cell_type	0.70
CGAS	regulates	gene	0.70
IBA1	activates	gene	0.70
CTSB	associated_with	gene	0.70
GENES	associated_with	gene	0.70
TFEB	causes	gene	0.70
SQSTM1	expressed_in	gene	0.70
AIM2	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
ACTB	activates	gene	0.70
ULK1	associated_with	gene	0.70
VAMP8	associated_with	gene	0.70
LC3	associated_with	gene	0.70
ASC	associated_with	gene	0.70
LYSOSOME	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
AR	activates	gene	0.70
CTSB	interacts_with	gene	0.70
SQSTM1	activates	gene	0.70
BECN1	associated_with	gene	0.70
ATG16L1	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Positioning Dynamics Modulation	0.686	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (8)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propag [PMID:39233232]	Bayati A, McPherson PS	J Biol Chem	2024	1
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM17 [PMID:37390818]	Zhang J, Zeng W, Han Y, Lee WR, Liou J,	Mol Cell	2023	1
Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279]	Saffire H Krance, Che-Yuan Wu, Alison C	Journal of Alzheimer's disease	2022	1
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641]	Zhang X, Wei M, Fan J, Yan W, Zha X, Son	Autophagy	2021	1
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. [PMID:16973206]	Eskelinen EL	Mol Aspects Med	2006	1
Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With [PMID:41287364]	Bizikova P, Matsumoto C, Ogino S, Tsukui	Vet Dermatol	2026	0
Measuring lysosome damage and lysophagy in vivo. [PMID:41485143]	Wu Z, Zhan H, Huang Z, Wang C, Li B et a	Autophagy	2026	0
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198]	Xiao F, Tan X, He A, Zhou Y, Xu K et al.	Autophagy	2026	0
Preparation of a polyclonal antibody against Lysosome-Associated Membrane Protei [PMID:41825675]	Luo J, Shi Y, Jiang X, Zhang B, Chen Y e	Int J Biol Macromol	2026	0
Increased Glycogenin-Exposed Residual Glycogen in Lysosomes Is the Early Patholo [PMID:41923452]	Shi Y, Zhang N, Sun H, Wang Y, Zhao D et	Muscle Nerve	2026	0
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components [PMID:37257946]	Idera A, Sharkey LM, Kurauchi Y, Kadoyam	Journal of pharmacological sci	2023	0
Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila. [PMID:35266854]	Chaudhry N, Sica M, Surabhi S, Hernandez	Autophagy	2022	0
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. [PMID:34102054]	Chin MY, Patwardhan AR, Ang KH, Wang AL,	ACS sensors	2021	0
ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysos [PMID:30538141]	Wang R, Tan J, Chen T, Han H, Tian R, Ta	The Journal of cell biology	2019	0
CD107a Degranulation Assay to Evaluate Immune Cell Antitumor Activity. [PMID:30465198]	Lorenzo-Herrero S, Sordo-Bahamonde C, Go	Methods in molecular biology (	2019	0
Circumventing kinetics in biogeochemical modeling. [PMID:31097587]	["Louca S", "Scranton M", "Taylor G", "A	Proceedings of the National Ac	2019	0
Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in t [PMID:29940787]	Cheng XT, Xie YX, Zhou B, Huang N, Farfe	Autophagy	2018	0
In Utero Brain Development in Fetuses With Congenital Heart Disease: Another Pie [PMID:29141841]	Mike Seed	Circulation. Cardiovascular im	2017	0
NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular ho [PMID:27694926]	["Struski S", "Lagarde S", "Bories P", "	Leukemia	2017	0
Comprehensive Analysis of Hypermutation in Human Cancer. [PMID:29056344]	["Campbell B", "Light N", "Fabrizio D",	Cell	2017	0

Debates (10)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning LAMP1 in their description or question text

No additional research found

LAMP1

Understanding Entity Pages

Summary

Wiki Pages (3)

LAMP1 Protein

LAMP1 Protein

Lysosomal Associated Membrane Protein 1 (LAMP1)

Pathway Diagram

Outgoing (910)

Incoming (679)

Targeting Hypotheses (1)

Mentioning Analyses (8)

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

Epigenetic reprogramming in aging neurons

Neuroinflammation and microglial priming in early AD

Tau propagation mechanisms and therapeutic interception points

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Mechanistic role of APOE in neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (1)

Related Papers (20)

Debates (10)

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

Investigate prion-like spreading of tau pathology through connected brain region

How does microglial priming contribute to early Alzheimer's disease pathology? F

Epigenetic reprogramming in aging neurons

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

Analysis question not specified

Neuroinflammation and microglial priming in early AD

Tau propagation mechanisms and therapeutic interception points

What gene expression changes in the aging mouse brain predict neurodegenerative

What are the mechanisms underlying what are the mechanisms by which gut microbio

Related Research