protein

TUMOR PROTEIN P53

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUMOR PROTEIN P53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

32Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for Tumor Protein P53

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🔬 Protein Info

Gene Symbol	TUMOR PROTEIN P53
Molecular Weight	43.7 kDa
Amino Acids	393 aa
Pathways	Chaperone
Interactions	AMPK, BECN1, CALCOCO2, CREB, CREBBP, EP300
KG Connections	84 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    TUMOR_PROTEIN_P53["TUMOR PROTEIN P53"]
    HSC70["HSC70"]
    TUMOR_PROTEIN_P53 -->|"activates"| HSC70
    PKM2["PKM2"]
    TUMOR_PROTEIN_P53 -->|"activates"| PKM2
    VPS34["VPS34"]
    TUMOR_PROTEIN_P53 -->|"activates"| VPS34
    KAT2B["KAT2B"]
    TUMOR_PROTEIN_P53 -->|"activates"| KAT2B
    TUMOR["TUMOR"]
    TUMOR_PROTEIN_P53 -->|"activates"| TUMOR
    PARKINSON["PARKINSON"]
    TUMOR_PROTEIN_P53 -->|"activates"| PARKINSON
    apoptosis["apoptosis"]
    TUMOR_PROTEIN_P53 -->|"activates"| apoptosis
    AMPK["AMPK"]
    TUMOR_PROTEIN_P53 -->|"activates"| AMPK
    MAP1LC3["MAP1LC3"]
    TUMOR_PROTEIN_P53 -->|"activates"| MAP1LC3
    CELL_CYCLE["CELL CYCLE"]
    TUMOR_PROTEIN_P53 -->|"activates"| CELL_CYCLE
    ACETYL_COA["ACETYL-COA"]
    TUMOR_PROTEIN_P53 -->|"activates"| ACETYL_COA
    ACAT1["ACAT1"]
    TUMOR_PROTEIN_P53 -->|"activates"| ACAT1
    Chaperone["Chaperone"]
    TUMOR_PROTEIN_P53 -->|"activates"| Chaperone
    disease["disease"]
    TUMOR_PROTEIN_P53 -->|"activates"| disease
    Proteins["Proteins"]
    TUMOR_PROTEIN_P53 -->|"activates"| Proteins
    GSK3["GSK3"]
    TUMOR_PROTEIN_P53 -->|"activates"| GSK3
    RAPAMYCIN["RAPAMYCIN"]
    TUMOR_PROTEIN_P53 -->|"activates"| RAPAMYCIN
    CHAPERONE_MEDIATED_AUTOPHAGY["CHAPERONE-MEDIATED AUTOPHAGY"]
    TUMOR_PROTEIN_P53 -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    cancer["cancer"]
    TUMOR_PROTEIN_P53 -->|"inhibits"| cancer
    TUMOR["TUMOR"]
    TUMOR_PROTEIN_P53 -->|"inhibits"| TUMOR
    Genes["Genes"]
    TUMOR_PROTEIN_P53 -->|"inhibits"| Genes
    PRKAA2["PRKAA2"]
    TUMOR_PROTEIN_P53 -->|"activates"| PRKAA2
    NFE2L2["NFE2L2"]
    TUMOR_PROTEIN_P53 -->|"activates"| NFE2L2
    MTORC1["MTORC1"]
    TUMOR_PROTEIN_P53 -->|"activates"| MTORC1
    GLP1R["GLP1R"]
    TUMOR_PROTEIN_P53 -->|"activates"| GLP1R
    ACOX1["ACOX1"]
    TUMOR_PROTEIN_P53 -->|"activates"| ACOX1
    ENDOTHELIAL["ENDOTHELIAL"]
    TUMOR_PROTEIN_P53 -->|"activates"| ENDOTHELIAL
    Fatty_Liver["Fatty Liver"]
    TUMOR_PROTEIN_P53 -->|"activates"| Fatty_Liver
    NAFLD["NAFLD"]
    TUMOR_PROTEIN_P53 -->|"activates"| NAFLD
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    TUMOR_PROTEIN_P53 -->|"activates"| ENDOTHELIAL_CELLS

Outgoing (32)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
PKM2	activates	protein	0.50
VPS34	activates	protein	0.50
KAT2B	activates	gene	0.50
TUMOR	activates	disease	0.50
PARKINSON	activates	gene	0.50
apoptosis	activates	process	0.50
AMPK	activates	protein	0.50
MAP1LC3	activates	gene	0.50
CELL CYCLE	activates	cell_type	0.50
ACETYL-COA	activates	concept	0.50
ACAT1	activates	concept	0.50
Chaperone	activates	pathway	0.50
disease	activates	disease	0.50
Proteins	activates	protein	0.50
GSK3	activates	concept	0.50
HSC70	activates	protein	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50
cancer	inhibits	disease	0.50
TUMOR	inhibits	disease	0.50
PRKAA2	activates	gene	0.50
NFE2L2	activates	gene	0.50
MTORC1	activates	concept	0.50
GLP1R	activates	concept	0.50
ACOX1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
Fatty Liver	activates	disease	0.50
NAFLD	activates	disease	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50

Incoming (54)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
OPTN	activates	gene	0.50
NDP52	activates	gene	0.50
FIP200	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
SNAP29	activates	gene	0.50
mTOR	activates	entity	0.50
WIPI2	activates	gene	0.50
PIK3C3	activates	gene	0.50
KAT8	activates	gene	0.50
GAPDH	activates	gene	0.50
TP53	activates	gene	0.50
SIRT1	activates	gene	0.50
RUBCN	activates	gene	0.50
HDAC6	activates	gene	0.50
CREBBP	activates	gene	0.50
EP300	activates	gene	0.50
LAMP2A	activates	gene	0.50
RB1CC1	activates	gene	0.50
KAT2A	activates	gene	0.50
KAT5	activates	gene	0.50
STX17	activates	gene	0.50
VAMP8	activates	gene	0.50
HSPA8	activates	gene	0.50
CALCOCO2	activates	gene	0.50
NBR1	activates	gene	0.50
CREB	activates	protein	0.50
SNARE	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
RUBICON	activates	protein	0.50
HSP70	activates	protein	0.50
UBIQUITIN	activates	protein	0.50
TP53	inhibits	gene	0.50
PHAGOCYTOSIS	activates	gene	0.50
STING1	activates	protein	0.50
KDM6B	activates	gene	0.50
FOXO1	activates	gene	0.50
GRK2	activates	gene	0.50
PLIN3	activates	gene	0.50
SREBF2	activates	gene	0.50
NOS3	activates	gene	0.50
HTRA2	activates	gene	0.50
PPARA	activates	gene	0.50
RPTOR	activates	gene	0.50
TFEB	activates	protein	0.50
SIRT3	activates	gene	0.50
SREBF1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUMOR PROTEIN P53 in their description or question text

No additional research found