gene

RUBCN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBCN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

344Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

6Experiments

0Debates

Summary

RUBCN is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with AD, ADH, AMI. Connected to 170 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RUBCN
Function	VPS34/BECN1 complex inhibition: Rubicon directly binds the BECN1-VPS34-UVRAG-VPS15 complex (Class III PI3K complex II) through its RUN domain, suppressing VPS34 lipid kinase activity and reducing PI3P
Pathways	PI3K
Ensembl ID	ENSG00000145016
GeneCards	RUBCN
Human Protein Atlas	RUBCN
Associated Diseases	AD, ADH, AMI, disease, Ischemia, Lupus
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, AND, ATG, ATP, AUTOPHAGY
KG Connections	344 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RUBCN Gene

gene · 790 words

→

Pathway Diagram

flowchart TD
    RUBCN["RUBCN
(Rubicon)"]
    
    %% Core autophagy pathway
    RUBCN -->|"regulates"| AUTOPHAGY["Autophagy
Pathway"]
    RUBCN -->|"activates"| LYSO_DEG["Lysosomal
Degradation"]
    RUBCN -->|"associated_with"| LC3["LC3
(Autophagosome
Marker)"]
    RUBCN -->|"associated_with"| NBR1["NBR1
(Autophagy
Receptor)"]
    RUBCN -->|"activates"| UVRAG["UVRAG
(Autophagy
Regulator)"]
    
    %% mTOR signaling
    RUBCN -->|"regulates"| MTOR["mTOR
Pathway"]
    RUBCN -->|"regulates"| RPS6["RPS6
(Ribosomal
Protein)"]
    MTOR -->|"inhibits"| AUTOPHAGY
    
    %% Metabolic regulation
    RUBCN -->|"associated_with"| LIPID_MET["Lipid
Metabolism"]
    RUBCN -->|"regulates"| SREBF1["SREBF1
(Lipid
Transcription)"]
    RUBCN -->|"associated_with"| MET_SYN["Metabolic
Syndrome"]
    
    %% Neurodegeneration outcomes
    RUBCN -->|"associated_with"| PARKINSON["Parkinson's
Disease"]
    RUBCN -->|"activates"| ALS["ALS
(Motor Neuron
Disease)"]
    RUBCN -->|"regulates"| ISCHEMIA["Cerebral
Ischemia"]
    
    %% Additional regulatory mechanisms
    RUBCN -->|"regulates"| EGFR["EGFR
(Growth Factor
Receptor)"]
    RUBCN -->|"activates"| SMURF1["SMURF1
(E3 Ligase)"]
    RUBCN -->|"associated_with"| APOPTOSIS["Apoptosis
Pathway"]
    
    %% Pathway connections
    AUTOPHAGY -->|"dysfunction"| PARKINSON
    AUTOPHAGY -->|"impaired"| ALS
    LIPID_MET -->|"dysregulation"| MET_SYN
    
    style RUBCN fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style LYSO_DEG fill:#1b5e20
    style MTOR fill:#4a1a6b
    style PARKINSON fill:#5d4400
    style ALS fill:#5d4400
    style MET_SYN fill:#ef5350
    style APOPTOSIS fill:#ef5350
    style LC3 fill:#4a1a6b
    style UVRAG fill:#4a1a6b
    style SREBF1 fill:#4a1a6b

Outgoing (194)

Target	Relation	Type	Str
AUTOPHAGY	inhibits	entity	0.95
Autophagosome-Lysosome Fusion	inhibits	process	0.95
autophagosome-lysosome fusion	inhibits	process	0.95
LAP	promotes	process	0.95
Macroautophagy	regulates	process	0.95
LYSOSOME	regulates	entity	0.90
VPS34	interacts_with	protein	0.90
Kidney Proximal Tubular Epithelial Cells	expressed_in	cell_type	0.90
Kidney Proximal Tubular Epithelial Cells	involved_in	cell_type	0.85
Metabolism	regulates	process	0.85
BECN1	interacts_with	protein	0.85
Proximal Tubular Epithelial Cells	expressed_in	cell_type	0.85
LIPID METABOLISM	regulates	entity	0.85
Phospholipid Mobilization	promotes	process	0.80
autophagy	regulates	process	0.80
Metabolic Regulation	regulates	process	0.80
AUTOPHAGY	associated_with	gene	0.70
LC3	associated_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Autophagy	associated_with	pathway	0.70
Mtor	associated_with	pathway	0.70
Fatty Acid Transfer	promotes	process	0.70
Lupus	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Metabolic Syndrome	causes	disease	0.65
Tumor	associated_with	disease	0.65
TP53	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
RB1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
PIK3C3	regulates	gene	0.60
RAC1	interacts_with	gene	0.60
LC3	activates	gene	0.60
PIK3C3	interacts_with	gene	0.60
EP300	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
Lysosomal Degradation	activates	pathway	0.60
Mtor	regulates	pathway	0.60

Incoming (150)

Source	Relation	Type	Str
lactate	modulates	pathway	0.90
Lipid Metabolism	regulates	process	0.80
BECN1	associated_with	gene	0.70
rapamycin	targets	drug	0.70
ATG	activates	gene	0.70
PIK3C3	regulates	gene	0.70
CAT	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
LRP2	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MYC	regulates	gene	0.60
MTOR	regulates	gene	0.60
EGFR	regulates	gene	0.60
PPARG	regulates	gene	0.60
LAMP1	regulates	gene	0.60
UVRAG	activates	gene	0.60
BECN1	regulates	gene	0.60
ACTB	activates	entity	0.60
CAT	activates	entity	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
GAPDH	activates	entity	0.60
HDAC6	activates	entity	0.60
HSP70	activates	entity	0.60
HSPA8	activates	entity	0.60
KAT2A	activates	entity	0.60
KAT2B	activates	entity	0.60
KAT5	activates	entity	0.60
KAT8	activates	entity	0.60
LAMP2A	activates	entity	0.60
HSC70	activates	gene	0.60
PPARA	regulates	gene	0.60
RUBCNL	associated_with	gene	0.60
ACTB	regulates	gene	0.60
CBP	activates	gene	0.60
SMURF1	activates	gene	0.60
CSNK1A1	activates	gene	0.60
MTORC1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
AMPK	activates	entity	0.60
GSK3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
PTEC-specific RUBCN knockout mice phenotype analysis	validation	kidney injury/metabolic syndro	0.900	PTEC-specific RUBCN knockout m	proposed	N/A
PTEC-specific RUBCN knockout mice phenotyping	validation	acute kidney injury and metabo	0.900	PTEC-specific RUBCN knockout m	proposed	N/A
RUBCN deficiency effects on lipid metabolism in isolated PTECs	exploratory	metabolic dysfunction	0.850	isolated RUBCN-deficient PTECs	proposed	N/A
RUBCN deficiency effects on PTEC lipid metabolism	exploratory	metabolic dysfunction	0.850	cultured RUBCN-deficient PTECs	proposed	N/A
Co-culture analysis of PTEC-hepatocyte fatty acid transfer	exploratory	metabolic syndrome	0.800	PTEC-hepatocyte transwell co-c	proposed	N/A
PTEC-hepatocyte co-culture fatty acid efflux study	exploratory	metabolic syndrome	0.800	PTEC-hepatocyte transwell co-c	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RUBCN in their description or question text

No additional research found