gene

WIPI2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

444Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for WIPI2 - WD Repeat Domain, Phosphoinositide Interacting 2

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🧬 Gene Info

Gene Symbol	WIPI2
Aliases	Page for WIPI2, WD repeat domain, phosphoinositide-interacting protein 2
Chromosome	7q36.3
Protein Family	PROPPIN family (beta-propeller, PI3P binding)
Function	encodes a 445-amino acid protein with a molecular mass of approximately 46 kDa.
Molecular Weight	46 kDa
Amino Acids	466 aa
Exons	16
Pathways	Autophagy, Cell Cycle, Mitophagy
UniProt ID	[Q9Y5P8](https://www.uniprot.org/uniprot/Q9Y5P8)
Ensembl ID	ENSG00000157911
GeneCards	WIPI2
Human Protein Atlas	WIPI2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Carcinoma, Dementia
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, Actin, ALS4, AMPK, amyotrophic lateral sclerosis, AND
KG Connections	444 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    WIPI2["WIPI2
Autophagy Regulator"]
    
    BECN1["BECN1
Autophagy Initiation"]
    PIK3C3["PIK3C3
PI3K Complex"]
    MTOR["MTOR
Growth Signaling"]
    
    NBR1["NBR1
Cargo Receptor"]
    NDP52["NDP52
Selective Autophagy"]
    VAMP8["VAMP8
Vesicle Fusion"]
    
    HDAC6["HDAC6
Protein Deacetylase"]
    HSP70["HSP70
Protein Folding"]
    
    Autophagy["Autophagy
Process"]
    ProteinAggregates["Protein Aggregate
Clearance"]
    
    ALS["Amyotrophic
Lateral Sclerosis"]
    PD["Parkinson's
Disease"]
    FTD["Frontotemporal
Dementia"]
    SMA["Spinal Muscular
Atrophy"]
    Ataxia["Ataxia"]
    
    WIPI2 -->|"interacts with"| BECN1
    WIPI2 -->|"interacts with"| PIK3C3
    BECN1 -->|"forms complex"| PIK3C3
    MTOR -->|"inhibits"| Autophagy
    
    WIPI2 -->|"recruits"| NBR1
    WIPI2 -->|"recruits"| NDP52
    WIPI2 -->|"regulates"| VAMP8
    
    WIPI2 -->|"activates"| Autophagy
    Autophagy -->|"promotes"| ProteinAggregates
    
    HDAC6 -->|"facilitates"| ProteinAggregates
    HSP70 -->|"assists"| ProteinAggregates
    
    WIPI2 -->|"dysfunction leads to"| ALS
    WIPI2 -->|"dysfunction leads to"| PD
    WIPI2 -->|"dysfunction leads to"| FTD
    WIPI2 -->|"dysfunction leads to"| SMA
    WIPI2 -->|"dysfunction leads to"| Ataxia
    
    style WIPI2 fill:#006494
    style Autophagy fill:#1b5e20
    style ProteinAggregates fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style PIK3C3 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style NBR1 fill:#4a1a6b
    style NDP52 fill:#4a1a6b
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style FTD fill:#5d4400
    style SMA fill:#5d4400
    style Ataxia fill:#5d4400

Outgoing (245)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.80
Reticulophagy	associated_with	process	0.80
Als	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
Autophagy	associated_with	pathway	0.70
MTOR	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
Rheumatoid Arthritis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Osteoarthritis	associated_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Epilepsy	expressed_in	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Senescence	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
cerebellum	expressed_in	brain_region	0.60
NFKB	associated_with	gene	0.60
Mapk	associated_with	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
ACTB	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
Innate Immunity	associated_with	pathway	0.60
Mitophagy	regulates	pathway	0.60
Apoptosis	activates	pathway	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
Autophagy	activates	pathway	0.60
Pi3K	interacts_with	pathway	0.60
AMPK	activates	gene	0.60
FURIN	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
ACETYL-COA	associated_with	gene	0.60

Incoming (199)

Source	Relation	Type	Str
CRL4	ubiquitinates	entity	0.80
VAPs	associated_with	protein	0.80
GABARAP	associated_with	gene	0.70
LC3	associated_with	gene	0.70
CALCOCO2	associated_with	gene	0.70
MAP1LC3	activates	gene	0.70
rapamycin	targets	drug	0.70
SQSTM1	associated_with	gene	0.70
RB1CC1	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
LYSOSOME	regulates	gene	0.70
PARKINSON	associated_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
RB1	associated_with	gene	0.70
LC3	activates	gene	0.70
PIK3C3	associated_with	gene	0.70
ATG	associated_with	gene	0.70
RETREG1	regulates	gene	0.60
SMN1	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
HTT	associated_with	gene	0.60
SETX	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
RB1	activates	gene	0.60
HUWE1	interacts_with	gene	0.60
HUWE1	activates	gene	0.60
HUWE1	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
NFKB	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
GSK3	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
PKM2	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
AND	associated_with	gene	0.60
DDB1	activates	gene	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
PIK3C3	activates	entity	0.60
RB1CC1	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WIPI2 in their description or question text

No additional research found