disease

NAFLD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAFLD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

451Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Disease Info

Associated Genes	AMPK, BECN1, FOXO1, KDM6B, LAMP2, NLRP3, NUP85, PPAR
Therapeutic Agents	gastrodin, hesperetin, Hesperetin, Postbiotics, Pterostilbene, SCHISANHENOL
KG Connections	205 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    NAFLD["NAFLD"] -->|"increases risk"| Atherosclerotic_Cardiovascular["Atherosclerotic Cardiovascular Disease"]
    style Atherosclerotic_Cardiovascular fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"associated"| METABOLIC_SYNDROME["METABOLIC_SYNDROME"]
    style METABOLIC_SYNDROME fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"contributes to"| STEATOHEPATITIS["STEATOHEPATITIS"]
    style STEATOHEPATITIS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"activates"| CIRRHOSIS["CIRRHOSIS"]
    style CIRRHOSIS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"implicated in"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"associated"| RNA_SPLICING["RNA SPLICING"]
    style RNA_SPLICING fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -.->|"inhibits"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style OXIDATIVE_PHOSPHORYLATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    hesperetin["hesperetin"] -->|"treats"| NAFLD["NAFLD"]
    style hesperetin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    NUP85["NUP85"] -->|"associated"| NAFLD["NAFLD"]
    style NUP85 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Triglyceride_Accumulation["Triglyceride Accumulation"] -->|"causes"| NAFLD["NAFLD"]
    style Triglyceride_Accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    gastrodin["gastrodin"] -->|"treats"| NAFLD["NAFLD"]
    style gastrodin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AMPK["AMPK"] -->|"protects against"| NAFLD["NAFLD"]
    style AMPK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style NAFLD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (134)

Target	Relation	Type	Str
Fatty Liver	associated_with	disease	1.00
Liver Cirrhosis	contributes_to	disease	0.95
Hepatocellular Carcinoma	contributes_to	disease	0.95
Inflammation	therapeutic_target	disease	0.85
Chronic Liver Disease	contributes_to	disease	0.85
Fatty Liver	therapeutic_target	disease	0.85
Fatty Liver	treats	disease	0.85
Atherosclerotic Cardiovascular Disease	increases_risk	disease	0.80
Mtor	activates	pathway	0.80
Lipid Metabolism	regulates	pathway	0.80
Oxidative Stress	activates	pathway	0.80
Inflammation	associated_with	disease	0.75
METABOLIC_SYNDROME	associated_with	disease	0.72
Autophagy	regulates	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Mtor	therapeutic_target	pathway	0.70
Lipid Metabolism	activates	pathway	0.70
Er Stress	associated_with	pathway	0.70
Hepatitis	associated_with	disease	0.65
EGF	regulates	gene	0.65
Fatty Liver	activates	disease	0.65
Insulin Resistance	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
AMPK	phosphorylates	gene	0.65
AMPK	targets	gene	0.65
Fatty Liver	causes	disease	0.65
Fatty Liver	biomarker_for	disease	0.65
Als	activates	disease	0.65
Hepatitis	treats	disease	0.65
STEATOHEPATITIS	contributes_to	disease	0.64
Foxo Signaling	activates	pathway	0.60
Jak-Stat	activates	pathway	0.60
Microbiota	activates	pathway	0.60
Proteasome	regulates	pathway	0.60
Chaperone	therapeutic_target	pathway	0.60
Lipid Metabolism	causes	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Unfolded Protein Response	therapeutic_target	pathway	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Complement	therapeutic_target	pathway	0.60
Autophagy	associated_with	pathway	0.60
Cholesterol	inhibits	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Inflammasome	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Senescence	regulates	pathway	0.60
Microbiota	regulates	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
Glycolysis	activates	pathway	0.60

Incoming (317)

Source	Relation	Type	Str
INFLAMMATION	therapeutic_target	gene	0.95
NUP85	associated_with	gene	0.95
Als	therapeutic_target	disease	0.95
Hfd	causes	phenotype	0.95
Pterostilbene	treats	compound	0.95
hesperetin	treats	drug	0.90
Autophagy	involved_in	process	0.90
DRAK2	aggravates	gene	0.90
Triglyceride Accumulation	causes	phenotype	0.90
AKT	activates	gene	0.85
OXIDATIVE STRESS	activates	gene	0.85
PI3K	activates	gene	0.85
INFLAMMATION	associated_with	gene	0.85
MTOR	activates	gene	0.85
gastrodin	treats	drug	0.85
Lipid Droplets	associated_with	phenotype	0.85
AMPK	protects_against	protein	0.80
Postbiotics	treats	compound	0.80
AMPK	therapeutic_target	pathway	0.80
PI3K/AKT Signaling Pathway	involved_in	pathway	0.80
Mitochondrial Impairment	contributes_to	phenotype	0.80
Fibrosis	therapeutic_target	disease	0.75
LDL	activates	gene	0.75
Cancer	associated_with	disease	0.75
INSULIN RESISTANCE	therapeutic_target	gene	0.75
APOPTOSIS	associated_with	gene	0.75
NF-κB	therapeutic_target	pathway	0.75
AUTOPHAGY	regulates	gene	0.75
GENES	activates	gene	0.75
MTOR	therapeutic_target	gene	0.75
CANCER	associated_with	gene	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
MTORC1	therapeutic_target	gene	0.75
DIABETES MELLITUS	causes	gene	0.75
LIPOPHAGY	therapeutic_target	gene	0.75
NRF2	activates	gene	0.75
AUTOPHAGY	associated_with	pathway	0.72
SCHISANHENOL	treats	drug	0.72
Hesperetin	treats	drug	0.70
OXIDATIVE STRESS	regulates	gene	0.65
CYP3A4	associated_with	gene	0.65
IL-6	regulates	gene	0.65
TNF-Α	regulates	gene	0.65
Metabolic Syndrome	contributes_to	disease	0.65
VEGFB	activates	gene	0.65
INSULIN RESISTANCE	regulates	gene	0.65
IRS1	activates	gene	0.65
Als	regulates	disease	0.65
PPAR	regulates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NAFLD in their description or question text

No additional research found