gene

EIF4EBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4EBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

326Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EIF4EBP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with ALS, Als, Atherosclerosis. Connected to 130 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EIF4EBP1
Full Name	Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Aliases	4E-BP1
Function	is a small (~117 amino acid) translational repressor protein that plays a critical role in regulating cap-dependent mRNA translation.
Molecular Weight	12 kDa
Amino Acids	117 aa
Pathways	mTOR, mtor, mTOR signaling
Ensembl ID	ENSG00000187840
GeneCards	EIF4EBP1
Human Protein Atlas	EIF4EBP1
Unphosphorylated 4E-BP1	High affinity for eIF4E, strong translation repression
Phosphorylated 4E-BP1	Reduced eIF4E binding, releases the translational brake
Synaptic proteins	NMDA receptor subunits, AMPA receptor components
Transcription factors	c-Fos, Arc, CREB
Trophic factors	BDNF, NGF
Associated Diseases	Als, Ataxia, Cancer, Infection, Metabolic Syndrome
Known Drugs/Compounds	rapamycin
Interactions	4E-BP1, ABCA1, ABCG1, ACTB, AKT, AKT1
KG Connections	326 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EIF4EBP1 — Eukaryotic Translation Initiation Factor 4E Binding Protein 1

gene · 2611 words

→

EIF4EBP1 Protein (4E-BP1)

protein · 526 words

→

Pathway Diagram

flowchart TD
    EIF4EBP1["EIF4EBP1
Translation Repressor"]
    MTOR["MTOR
Mechanistic Target
of Rapamycin"]
    MTOR_pathway["mTOR Signaling
Pathway"]
    Autophagy["Autophagy
Pathway"]
    MAP1LC3B["MAP1LC3B (LC3)
Autophagosome
Marker"]
    LAMP1["LAMP1
Lysosomal
Membrane"]
    Lysosomal_deg["Lysosomal
Degradation"]
    PPARGC1A["PPARGC1A
Metabolic
Coactivator"]
    Lipid_metabolism["Lipid Metabolism
Pathway"]
    RPS6["RPS6
Ribosomal
Protein S6"]
    MYC["MYC
Transcription
Factor"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    Ischemia["Cerebral
Ischemia"]
    Metabolic_syndrome["Metabolic
Syndrome"]

    MTOR -->|"phosphorylates/inhibits"| EIF4EBP1
    EIF4EBP1 -->|"regulates"| MTOR_pathway
    EIF4EBP1 -->|"regulates"| Autophagy
    EIF4EBP1 -->|"regulates"| MAP1LC3B
    EIF4EBP1 -->|"regulates"| LAMP1
    EIF4EBP1 -->|"activates"| Lysosomal_deg
    EIF4EBP1 -->|"regulates"| PPARGC1A
    EIF4EBP1 -->|"activates"| Lipid_metabolism
    EIF4EBP1 -->|"regulates"| RPS6
    EIF4EBP1 -->|"regulates"| MYC
    EIF4EBP1 -->|"interacts with"| ALS
    EIF4EBP1 -->|"regulates"| MS
    EIF4EBP1 -->|"regulates"| Ischemia
    EIF4EBP1 -->|"activates"| Metabolic_syndrome

    style EIF4EBP1 fill:#006494
    style Autophagy fill:#1b5e20
    style Lysosomal_deg fill:#1b5e20
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Ischemia fill:#ef5350
    style Metabolic_syndrome fill:#5d4400
    style MTOR fill:#4a1a6b
    style PPARGC1A fill:#4a1a6b
    style MYC fill:#4a1a6b

Outgoing (205)

Target	Relation	Type	Str
mRNA Translation	regulates	process	0.90
EIF4F	regulates	protein	0.90
Mrna Translation	modulates	process	0.85
Mtor	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
ROS	activates	gene	0.70
Ischemia	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Ms	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	interacts_with	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
SMAD	activates	gene	0.60
TGFB	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
senescence	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
GFP	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
Mtor	regulates	pathway	0.60
Mtor	inhibits	pathway	0.60
TSC1	activates	gene	0.60
MTOR	activates	gene	0.60
GENES	interacts_with	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
RAS	activates	gene	0.60
LDL	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
PCNA	activates	gene	0.60
TFEB	regulates	gene	0.60
Cholesterol	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Pi3K	inhibits	pathway	0.60
Akt	inhibits	pathway	0.60
ATG	regulates	gene	0.60
GLB1	activates	gene	0.60

Incoming (121)

Source	Relation	Type	Str
MTOR	activates	gene	0.90
MTOR	phosphorylates	protein	0.85
ATP	activates	gene	0.70
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
CTSB	activates	gene	0.60
ATM	activates	gene	0.60
ATR	activates	gene	0.60
CASP3	activates	gene	0.60
DYNLL1	activates	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
MTORC1	regulates	gene	0.60
ATG	regulates	gene	0.60
NADH	regulates	gene	0.60
LDL	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
RAS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ATP	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MICROTUBULES	associated_with	gene	0.60
ACETYL-COA	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
ATG	activates	gene	0.60
CPT1A	activates	gene	0.60
rapamycin	targets	drug	0.60
CAT	activates	entity	0.60
AKT	activates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
ABCA1	interacts_with	gene	0.60
EGFR	regulates	gene	0.60
PTEN	activates	gene	0.60
RPS6	activates	gene	0.60
RHEB	activates	gene	0.60
AKT1	activates	gene	0.60
RPS6KB1	activates	gene	0.60
PDPK1	activates	gene	0.60
TSC2	activates	gene	0.60
ACTB	activates	entity	0.60
CTSD	activates	entity	0.60
EGFR	activates	entity	0.60
ABCA1	activates	entity	0.60
ABCG1	activates	entity	0.60
APOA1	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF4EBP1 in their description or question text

No additional research found