gene

HDAC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1123Connections

5Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

Cytoplasmic deacetylase critical for protein quality control, aggresome formation, and autophagy in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	HDAC6
Full Name	Histone Deacetylase 6
Chromosome	Xp11.23
Protein Type	Protein
Function	is a unique class IIb histone deacetylase that predominantly localizes to the cytoplasm rather than the nucleus.
Primary Expression	Ubiquitous, highest in brain, liver, kidney
Molecular Weight	131 kDa
Amino Acids	1215 aa
Pathways	AUTOPHAGY, Amyloid, Autophagy, Dna Repair, Inflammasome
UniProt ID	Q9UQR8
NCBI Gene ID	10013
Ensembl ID	ENSG00000094631
GeneCards	HDAC6
Human Protein Atlas	HDAC6
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer, Cardiovascular, Diabetes
Known Drugs/Compounds	curcumin, lithium, Ramalin, rapamycin
Interactions	ACAT1, ACTB, Actin, ADCY3, AGING, AGO2
SciDEX Hypotheses	HDAC6 Selective Inhibition to Restore Acetylation HDAC6 Inhibition for Dual Restoration of Microtubu HDAC6 Inhibitor Therapy for Pan-Neurodegenerative
KG Connections	1123 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HDAC6 — AlphaFold Q9UQR8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HDAC6(["HDAC6"])
    Autophagic_Degradation("Autophagic Degradation")
    P62(["P62"])
    PROTEASOME["PROTEASOME"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    Cancer["Cancer"]
    OPTN(["OPTN"])
    Autophagy["Autophagy"]
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    UBIQUITIN(["UBIQUITIN"])
    Tumor["Tumor"]
    Parkinson["Parkinson"]

    HDAC6 -->|"regulates"| Autophagic_Degradation
    P62 -->|"modulates"| HDAC6
    PROTEASOME -->|"modulates"| HDAC6
    HDAC6 -->|"regulates"| Alzheimer
    HDAC6 -->|"regulates"| Als
    HDAC6 -->|"regulates"| Cancer
    HDAC6 -->|"activates"| Als
    HDAC6 -->|"therapeutic target"| Als
    HDAC6 -->|"interacts with"| OPTN
    HDAC6 -->|"activates"| Autophagy
    HDAC6 -->|"regulates"| OXIDATIVE_STRESS
    HDAC6 -->|"activates"| UBIQUITIN
    HDAC6 -->|"associated with"| Tumor
    HDAC6 -->|"associated with"| Parkinson
    HDAC6 -->|"associated with"| Cancer

    style HDAC6 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (743)

Target	Relation	Type	Str
Macroautophagy	involved_in	process	0.95
Autophagosome-Lysosome Fusion	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
neurodegeneration	inhibits	disease	0.90
Lewy Bodies	component_of	structure	0.90
Autophagosome-Lysosome Fusion	promotes	process	0.90
CTTN	regulates	gene	0.90
Parkinson Disease	associated_with	disease	0.85
Proteasomal Inhibition	mediates	mechanism	0.85
Tubulin Acetylation	catalyzes	process	0.85
acetylation	inhibits	process	0.85
Synaptic Failure	contributes_to	process	0.85
Protein Aggregates	degrades	structure	0.85
Memory Restoration	targets	phenotype	0.82
F-actin cytoskeleton	regulates	pathway	0.80
P62	interacts_with	protein	0.80
epigenetic regulation	participates_in	pathway	0.80
NLRP3 inflammasome	activates	protein	0.80
neuroinflammation	regulates	disease	0.80
PIK3C3	regulates	gene	0.80
neuroinflammation	inhibits	disease	0.80
Multiple System Atrophy	associated_with	disease	0.80
neural stem cells	regulates	cell_type	0.80
neural stem cells	activates	cell_type	0.80
Α-Tubulin	modulates	protein	0.75
TAU	associated_with	protein	0.75
Cancer	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
Als	activates	disease	0.75
Alzheimer	regulates	disease	0.75
MTOR	regulates	gene	0.70
TFEB	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
ULK1	regulates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
neurodegeneration	regulates	disease	0.70
AMPK signaling	participates_in	pathway	0.70
STROKE	inhibits	disease	0.70
apoptosis pathway	participates_in	pathway	0.70
Parkinson's disease	activates	disease	0.70
OPTN	interacts_with	protein	0.70
UBIQUITIN	activates	gene	0.70
Parkinson's disease	regulates	disease	0.70
Alzheimer's disease	inhibits	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
Autophagy	activates	pathway	0.70
NEURONS	targets	cell_type	0.65
Cardiovascular	regulates	disease	0.65

Incoming (380)

Source	Relation	Type	Str
ISG15	inhibits	gene	0.95
ISG15	binds	gene	0.90
h-ca454967	targets_gene	hypothesis	0.90
SGK1	upregulates	gene	0.90
BACE1	interacts_with	gene	0.80
PIK3C3	phosphorylates	protein	0.80
ATG	regulates	gene	0.70
ATG	activates	gene	0.70
Ramalin	inhibits	gene	0.70
AR	activates	gene	0.70
rapamycin	targets	drug	0.70
BACE1	activates	gene	0.70
MAPT	treats	gene	0.65
NEURODEGENERATION	inhibits	disease	0.65
NEK1	causes	gene	0.65
MAPT	inhibits	gene	0.65
BACE1	co_discussed	gene	0.65
BDNF	co_discussed	gene	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
AND	activates	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
DNA	regulates	gene	0.60
AND	regulates	gene	0.60
AND	contributes_to	gene	0.60
GENES	associated_with	gene	0.60
AND	interacts_with	gene	0.60
AND	inhibits	gene	0.60
AMPK	regulates	gene	0.60
PER	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MOB1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
NF-ΚB	interacts_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMPK	activates	entity	0.60
HDAC	expressed_in	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
WT1	associated_with	gene	0.60
ACAT1	activates	gene	0.60
GSK3	activates	gene	0.60
TUBULIN	regulates	gene	0.60
P62	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
UVRAG	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism	0.682	neurodegeneration	Do SCFAs directly modulate α-synuclein a
HDAC6 Selective Inhibition to Restore Acetylation Balance an	0.643	structural biology	What is the atomic-resolution structure
Brain-Ester Prodrug Strategy for CNS-Selective HDAC6 Inhibit	0.570	pharmacology	How can CNS-selective HDAC/DNMT inhibito
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili	0.484	neurodegeneration	Which tau PTMs are both disease-specific
HDAC6 Inhibitor Therapy for Pan-Neurodegenerative Protein Ho	0.450	neurodegeneration	Comparative epigenetic signatures across

Mentioning Analyses (3)

Scientific analyses that reference this entity

Comparative epigenetic signatures across AD, PD, and ALS

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.550

Which tau PTMs are both disease-specific and druggable with selective small mole

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.484

What is the atomic-resolution structure of K280-acetylated tau and how does it t

structural biology | 2026-04-13 | 1 hypotheses Top: 0.643

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

What are the shared DNA methylation age acceleration and histone modification pa

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The debate proposed K280 acetylation creates a β-sheet nucleation interface but

closed · Rounds: 4 · Score: 0.86 · 2026-04-14

The debate proposed K280 acetylation creates a β-sheet nucleation interface but

closed · Rounds: 4 · Score: 0.74 · 2026-04-14

The debate highlighted promising PTMs like K280 acetylation and O-GlcNAcylation

closed · Rounds: 4 · Score: 0.65 · 2026-04-13

Related Research

Hypotheses and analyses mentioning HDAC6 in their description or question text

No additional research found

HDAC6

Understanding Entity Pages

Summary

Wiki Pages (7)

HDAC6 Protein

HDAC6 Protein

HDAC6 Modulation Therapy for Neurodegeneration

HDAC6 Agonist for Neuronal Aggrephagy

HDAC6 Gene - Histone Deacetylase 6

HDAC6 Protein

HDAC6 (Redirect)

Pathway Diagram

Outgoing (743)

Incoming (380)

Targeting Hypotheses (5)

Mentioning Analyses (3)

Comparative epigenetic signatures across AD, PD, and ALS

Which tau PTMs are both disease-specific and druggable with selective small mole

What is the atomic-resolution structure of K280-acetylated tau and how does it t

Experiments (0)

Related Papers (0)

Debates (4)

What are the shared DNA methylation age acceleration and histone modification pa

The debate proposed K280 acetylation creates a β-sheet nucleation interface but

The debate proposed K280 acetylation creates a β-sheet nucleation interface but

The debate highlighted promising PTMs like K280 acetylation and O-GlcNAcylation

Related Research