gene

EP300

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EP300: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

575Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EP300 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 390 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EP300
Chromosome	22q13.2
Protein Type	Transferase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Ubiquitous, highest in brain
Molecular Weight	300 kDa
Amino Acids	414 aa
Pathways	NF-κB
GeneCards	EP300
Human Protein Atlas	EP300
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma
Known Drugs/Compounds	Acetyl-CoA, rapamycin
Interactions	ACAT1, AMPK, AND, ATG, AUTOPHAGY, BRD4
KG Connections	575 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EP300 Gene

gene · 608 words

→

EP300 Protein (p300)

protein · 917 words

→

Pathway Diagram

graph TD
    EP300["EP300"] -->|"Regulates"| histone_H2B_acetylation["histone H2B acetylation"]
    EP300["EP300"] -->|"Associated With"| Tumor["Tumor"]
    EP300["EP300"] -->|"Associated With"| Parkinson["Parkinson"]
    EP300["EP300"] -->|"Therapeutic Target"| Glioblastoma["Glioblastoma"]
    EP300["EP300"] -->|"Therapeutic Target"| Cancer["Cancer"]
    EP300["EP300"] -->|"Therapeutic Target"| Ms["Ms"]
    EP300["EP300"] -->|"Therapeutic Target"| Fibrosis["Fibrosis"]
    EP300["EP300"] -->|"Therapeutic Target"| Hepatitis["Hepatitis"]
    OPTN["OPTN"] -->|"Associated With"| EP300["EP300"]
    ULK1["ULK1"] -->|"Associated With"| EP300["EP300"]
    CALCOCO2["CALCOCO2"] -->|"Associated With"| EP300["EP300"]
    HSPA8["HSPA8"] -->|"Associated With"| EP300["EP300"]
    STX17["STX17"] -->|"Associated With"| EP300["EP300"]
    style EP300 fill:#8d4900,color:#e0e0e0
    style histone_H2B_acetylation fill:#1b5e20,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style HSPA8 fill:#8d4900,color:#e0e0e0
    style STX17 fill:#8d4900,color:#e0e0e0

Outgoing (370)

Target	Relation	Type	Str
Histone Acetylation	regulates	process	0.90
RPTOR	phosphorylates	protein	0.85
ESR1	interacts_with	protein	0.80
Cancer	therapeutic_target	disease	0.75
Cancer	expressed_in	disease	0.75
Tumor	expressed_in	disease	0.75
SIRT1	interacts_with	gene	0.70
histone H2B acetylation	regulates	process	0.70
epigenetic regulation	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Als	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Hypertension	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	activates	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	activates	disease	0.65
Leukemia	activates	disease	0.65
Migraine	associated_with	disease	0.65
Cancer	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Glioblastoma	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
PI3K	co_discussed	gene	0.65
Ms	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
STAT3	co_discussed	gene	0.65

Incoming (205)

Source	Relation	Type	Str
CBX3	interacts_with	protein	0.93
CBX3	binds	gene	0.90
Acetyl-CoA	activates	compound	0.90
CANCER	expressed_in	gene	0.70
P53	expressed_in	gene	0.70
AKT	co_discussed	gene	0.65
HDAC6	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
CREBBP	associated_with	gene	0.60
AMPK	activates	entity	0.60
ATG	associated_with	gene	0.60
NATURAL COMPOUNDS	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
CREB	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
APOPTOSIS	associated_with	gene	0.60
GSK3	associated_with	gene	0.60
P53	associated_with	gene	0.60
RUBCNL	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
MAPK	interacts_with	gene	0.60
AMPK	associated_with	gene	0.60
ACAT1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
rapamycin	targets	drug	0.60
AND	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
DNA	expressed_in	gene	0.60
OPTN	associated_with	gene	0.60
AKT	targets	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
EGFR	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EP300 in their description or question text

No additional research found