Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUMOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | AGING, AKT, AKT1, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOPTOSIS, APP |
| KG Connections | 1177 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
TUMOR["TUMOR"]
UBIQUITIN(["UBIQUITIN"])
TUMOR -->|"causes"| UBIQUITIN
ULK1(["ULK1"])
TUMOR -->|"causes"| ULK1
VEGF(["VEGF"])
TUMOR -->|"activates"| VEGF
TP53(["TP53"])
TP53 -->|"associated_with"| TUMOR
MAGI2(["MAGI2"])
MAGI2 -->|"associated_with"| TUMOR
INSULIN_RESISTANCE["INSULIN RESISTANCE"]
INSULIN_RESISTANCE -->|"associated_with"| TUMOR
ER_STRESS["ER STRESS"]
ER_STRESS -->|"associated_with"| TUMOR
style TUMOR fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | inhibits | disease | 1.00 |
| Leukemia | activates | disease | 1.00 |
| Immune Checkpoint | activates | pathway | 1.00 |
| Invasion | associated_with | pathway | 1.00 |
| Breast Cancer | inhibits | disease | 1.00 |
| Apoptosis | treats | pathway | 1.00 |
| Carcinoma | expressed_in | disease | 1.00 |
| Ovarian Cancer | inhibits | disease | 1.00 |
| Invasion | expressed_in | pathway | 1.00 |
| Liver Cancer | therapeutic_target | disease | 1.00 |
| Carcinoma | regulates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Stem Cell | inhibits | pathway | 1.00 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 1.00 |
| Infection | therapeutic_target | disease | 1.00 |
| Melanoma | associated_with | disease | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Autoimmune | therapeutic_target | disease | 1.00 |
| Als | biomarker_for | disease | 1.00 |
| Metastasis | expressed_in | pathway | 1.00 |
| Immunotherapy | therapeutic_target | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Cell Cycle | therapeutic_target | pathway | 1.00 |
| Infection | regulates | disease | 1.00 |
| Microrna | therapeutic_target | pathway | 1.00 |
| Checkpoint Inhibitor | therapeutic_target | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Lung Cancer | therapeutic_target | disease | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| Glioblastoma | associated_with | disease | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Lung Cancer | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Lung Cancer | inhibits | disease | 1.00 |
| Ovarian Cancer | therapeutic_target | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Prostate Cancer | activates | disease | 1.00 |
| Immunotherapy | inhibits | pathway | 1.00 |
| Glioblastoma | activates | disease | 1.00 |
| Lymphoma | therapeutic_target | disease | 1.00 |
| Glioma | activates | disease | 1.00 |
| Immune Checkpoint | inhibits | pathway | 1.00 |
| Invasion | activates | pathway | 1.00 |
| Chemoresistance | activates | pathway | 1.00 |
| Breast Cancer | activates | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOPTOSIS | treats | gene | 1.00 |
| Colorectal Cancer | therapeutic_target | disease | 1.00 |
| DNA | treats | gene | 1.00 |
| INFLAMMATION | causes | gene | 1.00 |
| LYSOSOME | therapeutic_target | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| RAS | therapeutic_target | gene | 1.00 |
| OVERVIEW | regulates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| ATP | inhibits | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Colorectal Cancer | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| MICRORNAS | expressed_in | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| TLR4 | inhibits | gene | 1.00 |
| Colorectal Cancer | inhibits | disease | 1.00 |
| IL-6 | activates | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| STAT3 | regulates | gene | 1.00 |
| GAIN | inhibits | gene | 1.00 |
| CYTOKINES | therapeutic_target | gene | 1.00 |
| MTOR | treats | gene | 1.00 |
| RAS | inhibits | gene | 1.00 |
| AMPK | inhibits | gene | 1.00 |
| KRAS | associated_with | gene | 1.00 |
| IL-6 | inhibits | gene | 1.00 |
| STAT3 | treats | gene | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| BAX | inhibits | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| BCL2 | inhibits | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| MITOPHAGY | inhibits | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| PHAGOCYTOSIS | activates | gene | 1.00 |
| CGAS-STING | activates | gene | 1.00 |
| IL-6 | therapeutic_target | gene | 1.00 |
| HIPPO | therapeutic_target | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| EGF | activates | gene | 1.00 |
| MIRNAS | inhibits | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Tumor-derived extracellular vesicles as TREM2 ligands | 0.490 | neurodegeneration | Does the cancer-cystatin-C-TREM2 pathway |
| Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro | 0.438 | - | - |
| Direct C1q Binding Enables FcγR-Independent Complement Activ | 0.138 | molecular biology | Does Alectinib truly bind C1q directly w |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TUMOR in their description or question text
No additional research found