gene

KAT5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KAT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

192Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

KAT5 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Parkinson, Tumor. Connected to 92 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KAT5
Full Name	Lysine Acetyltransferase 5
Chromosome	11q13.1
Protein Type	Transferase
Function	KAT5 (also known as TIP60 - TAT-interactive protein 60 kDa) is a histone acetyltransferase that acetylates histone H2A and H4.
Primary Expression	the brain with high expression in hippocampus and cortex
Molecular Weight	60 kDa
Pathways	Chaperone, Wnt signaling, apoptosis, apoptosis pathway, autophagy pathway
UniProt ID	[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)
Ensembl ID	ENSG00000101158
OMIM	601409
GeneCards	KAT5
Human Protein Atlas	KAT5
Associated Diseases	Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, ATG, CALCOCO2, CBP, CREB
KG Connections	192 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KAT5 — Lysine Acetyltransferase 5

gene · 528 words

→

KAT5 Protein — Lysine Acetyltransferase 5 (TIP60)

protein · 616 words

→

Pathway Diagram

graph TD
    KAT5["KAT5"]
    KAT5 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    KAT5 ---|"associated"| Tumor["Tumor"]
    KAT5 ---|"associated"| Parkinson["Parkinson"]
    KAT5 ---|"associated"| WIPI2["WIPI2"]
    KAT5 ---|"associated"| BECN1["BECN1"]
    KAT5 ---|"associated"| HDAC6["HDAC6"]
    KAT5 ---|"associated"| CREBBP["CREBBP"]
    LYSOSOME["LYSOSOME"] -->|"regulates"| KAT5
    OPTN["OPTN"] ---|"associated"| KAT5
    ULK1["ULK1"] ---|"associated"| KAT5
    CALCOCO2["CALCOCO2"] ---|"associated"| KAT5
    HSPA8["HSPA8"] ---|"associated"| KAT5
    STX17["STX17"] ---|"associated"| KAT5
    SQSTM1["SQSTM1"] ---|"associated"| KAT5

Outgoing (107)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:KAT5	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Apoptosis	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
neurodegeneration	regulates	disease	0.60
Cell Cycle	associated_with	pathway	0.60
Chaperone	associated_with	pathway	0.60
RUBCNL	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
UBIQUITIN	associated_with	gene	0.60
KAT8	activates	entity	0.60
LAMP2A	activates	entity	0.60
MTOR	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
PIK3C3	activates	entity	0.60
RB1CC1	activates	entity	0.60
RUBCN	activates	entity	0.60
SIRT1	activates	entity	0.60
SNAP29	activates	entity	0.60
SQSTM1	activates	entity	0.60
STX17	activates	entity	0.60
TFEB	activates	entity	0.60
TP53	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
ULK1	activates	entity	0.60
VAMP8	activates	entity	0.60
WIPI2	activates	entity	0.60
Mtor	associated_with	pathway	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60

Incoming (85)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:KAT5	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ACAT1	activates	gene	0.60
AMPK	activates	entity	0.60
KAT2A	activates	entity	0.60
KAT2B	activates	entity	0.60
LYSOSOME	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
ATG	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
CREB	associated_with	gene	0.60
P53	associated_with	gene	0.60
GSK3	associated_with	gene	0.60
RUBCNL	associated_with	gene	0.60
AND	associated_with	gene	0.60
HSC70	activates	gene	0.60
P62	associated_with	gene	0.60
TP53	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
GAPDH	activates	entity	0.60
HDAC6	activates	entity	0.60
HSP70	activates	entity	0.60
HSPA8	activates	entity	0.60
NDP52	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity