concept

AUTOPHAGOSOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGOSOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

176Connections

5Hypotheses

0Analyses

2Outgoing

50Incoming

8Experiments

0Debates

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💡 Concept Info

Name	AUTOPHAGOSOME
Key Genes/Proteins	4E-BP1, ABCA1, ABCG1, ACTB, ALZHEIMER, APOA1
Related Diseases	Alzheimer Disease, atherosclerosis

Pathway Diagram

graph TD
    AUTOPHAGOSOME["AUTOPHAGOSOME"]
    AUTOPHAGOSOME -->|"inhibits"| LYSOSOME["LYSOSOME"]
    AUTOPHAGOSOME -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGOSOME -->|"activates"| P62["P62"]
    AUTOPHAGOSOME -->|"activates"| LC3["LC3"]
    CALCOCO2["CALCOCO2"] -->|"involved_in"| AUTOPHAGOSOME
    ATTEC["ATTEC"] -->|"targets"| AUTOPHAGOSOME
    ATG7["ATG7"] -->|"activates"| AUTOPHAGOSOME
    SQSTM1["SQSTM1"] -->|"activates"| AUTOPHAGOSOME
    ATG5["ATG5"] -->|"activates"| AUTOPHAGOSOME
    APP["APP"] -->|"inhibits"| AUTOPHAGOSOME
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"activates"| AUTOPHAGOSOME
    AMPK["AMPK"] -->|"activates"| AUTOPHAGOSOME

Outgoing (2)

Target	Relation	Type	Str
Autophagy Pathway	involved_in	pathway	0.95
CEREBRAL CORTEX	inhibits	concept	0.50

Incoming (174)

Source	Relation	Type	Str
LC3	involved_in	protein	0.95
LC3	part_of	gene	0.90
CDKN1A	associated_with	protein	0.90
CDKN2A	associated_with	protein	0.90
Autophagy Machinery	mediates	mechanism	0.90
ATTEC	targets	compound	0.85
L1CAM	transports	protein	0.85
CALCOCO2	involved_in	protein	0.85
SDC1	transports	protein	0.80
SQSTM1	activates	protein	0.70
ABCG1	activates	gene	0.50
ACTB	activates	gene	0.50
APOA1	activates	gene	0.50
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
EIF4EBP1	activates	gene	0.50
4E-BP1	activates	protein	0.50
Cholesterol	activates	pathway	0.50
CALCOCO2	activates	gene	0.50
SELECTIVE AUTOPHAGY	associated_with	concept	0.50
NDP52	interacts_with	gene	0.50
FIP200	interacts_with	gene	0.50
TAX1BP1	interacts_with	gene	0.50
Neurodegeneration	associated_with	disease	0.50
OPTN	associated_with	gene	0.50
NEUROTOXICITY	activates	concept	0.50
atherosclerosis	activates	disease	0.50
EGR1	activates	protein	0.50
P2RY12	activates	gene	0.50
SQSTM1	activates	gene	0.50
MAP1LC3	activates	gene	0.50
ABCA1	activates	gene	0.50
Proteins	inhibits	protein	0.50
disease	regulates	disease	0.50
OPTN	activates	gene	0.50
BECN1	activates	gene	0.50
Autophagy	associated_with	process	0.50
UBIQUITIN	interacts_with	protein	0.50
MAP1LC3	interacts_with	gene	0.50
VPS4A	inhibits	gene	0.50
cancer	inhibits	disease	0.50
TUMOR	activates	disease	0.50
apoptosis	activates	process	0.50
Reactive Oxygen Species	activates	process	0.50
HSP27	associated_with	protein	0.50
HSP27	activates	protein	0.50
LC3B	activates	protein	0.50
CELL DEATH	inhibits	concept	0.50
GABARAP	interacts_with	protein	0.50
LYSOSOME	interacts_with	gene	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.734	neurodegeneration	What molecular mechanisms link elevated
Autophagosome Maturation Checkpoint Control	0.709	neurodegeneration	Autophagy-lysosome pathway convergence a
Axonal Transport Defect: C9orf72 hexanucleotide expansion im	0.660	neurodegeneration	What are the neuron-specific effects of
Autophagosome-Lysosome Fusion Defects as Primary Driver of α	0.630	neurodegeneration	Gap 006 analysis (archived stub)
Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-	0.600	neurodegeneration	What are the neuron-specific effects of

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy Enhancement Drug Screening for Neurodegeneration	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Macroautophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,730,000

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Acetylation in the regulation of autophagy. [PMID:35435793]	Xu Y, Wan W	Autophagy	2023	1
New insights regarding SNARE proteins in autophagosome-lysosome fusion. [PMID:32924745]	Tian X, Teng J, Chen J	Autophagy	2021	1
Autophagosomes form at ER-mitochondria contact sites. [PMID:23455425]	Hamasaki M, Furuta N, Matsuda A, Nezu A,	Nature	2013	1
SNX16 functions as a nutrient-sensitive regulator of autophagosomal components r [PMID:41593027]	Que H, Rong Y	Autophagy	2026	0
Downhill Running Blocks the Mitophagic Flux and Autophagosome-Lysosome Fusion in [PMID:41630123]	Deng H, Zheng S, Li M, Zhang D, Yang T,	Medicine and science in sports	2026	0
Rapid optogenetic manipulation of autophagy reveals that the nuclear pore comple [PMID:41676542]	Mondal P, Cyril A, Parham L, Mamriev D,	bioRxiv : the preprint server	2026	0
NK cell-derived GZMB (granzyme B) suppresses glioblastoma radioresistance by blo [PMID:41378763]	Yan J, Feng R, Qin Q, Shen G, Tian M, Li	Autophagy	2026	0
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-medi [PMID:40327696]	["Dash B", "Urano Y", "Mita Y", "Ashida	Proceedings of the National Ac	2025	0
CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosom [PMID:41413248]	Yang J, Liao C, Liang X, Ke Y, Sun Y, Hu	Cell death and differentiation	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pat [PMID:33632058]	["Beckers J", "Tharkeshwar A", "Van Damm	Autophagy	2021	0
Automated Software System to Promote Anticoagulation and Reduce Stroke Risk: Clu [PMID:28119433]	["Holt T", "Dalton A", "Marshall T", "Fa	Stroke	2017	0
Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (synt [PMID:24113031]	["Heged\u0171s K", "Tak\u00e1ts S", "Kov	Autophagy	2013	0
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. [PMID:23791177]	["Buchan J", "Kolaitis R", "Taylor J", "	Cell	2013	0
Actinic lichen nitidus. [PMID:25386247]	["Blalock T", "Kannan S", "Davis L"]	Dermatology reports	2010	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AUTOPHAGOSOME in their description or question text

No additional research found