gene

LRP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

267Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LRP2 gene page for neurodegenerative disease research

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🧬 Gene Info

Gene Symbol	LRP2
Full Name	Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)
Aliases	Page for LRP2 Protein, Megalin
Chromosome	2q31.1
Protein Type	Protein
Function	is a giant multiligand endocytic receptor of the LDL receptor family with high physiological relevance at epithelial interfaces, including the choroid plexus and brain barriers.
Molecular Weight	600 kDa
Amino Acids	630 aa
Exons	79
Pathways	Angiogenesis, Apoptosis, Autophagy, Lipid Metabolism, Mtor
UniProt ID	Search UniProt
GeneCards	LRP2
Human Protein Atlas	LRP2
Associated Diseases	AD, ADH, Aging, Als, AMI
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AND, APOPTOSIS, ATG, ATP, CANCER
KG Connections	267 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LRP2 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    LRP2["LRP2
(Low-density lipoprotein
receptor-related protein 2)"]
    
    %% Direct regulatory targets
    MAP1LC3B["MAP1LC3B
(Autophagy marker
LC3B)"]
    MYC["MYC
(Oncogene
transcription factor)"]
    
    %% Pathological processes
    Neurodegeneration["Neurodegeneration
(Progressive neuron
loss)"]
    ALS["ALS
(Amyotrophic lateral
sclerosis)"]
    FTD["FTD
(Frontotemporal
dementia)"]
    
    %% Inflammatory and immune responses
    Inflammation["Inflammation
(Immune response
activation)"]
    Autoimmune["Autoimmune
(Self-reactive
immunity)"]
    
    %% Vascular pathology
    Ischemia["Ischemia
(Reduced blood
flow)"]
    Stroke["Stroke
(Cerebrovascular
accident)"]
    Atherosclerosis["Atherosclerosis
(Arterial plaque
formation)"]
    
    %% Metabolic dysfunction
    MetabolicSyndrome["Metabolic Syndrome
(Insulin resistance
 and dyslipidemia)"]
    
    %% Outcomes
    Aging["Aging
(Cellular
senescence)"]
    
    %% Connections
    LRP2 -->|"regulates"| MAP1LC3B
    LRP2 -->|"regulates"| MYC
    LRP2 -->|"activates"| Neurodegeneration
    LRP2 -->|"activates"| ALS
    LRP2 -->|"associated_with"| FTD
    LRP2 -->|"activates"| Inflammation
    LRP2 -->|"activates"| Autoimmune
    LRP2 -->|"regulates"| Ischemia
    LRP2 -->|"associated_with"| Stroke
    LRP2 -->|"associated_with"| Atherosclerosis
    LRP2 -->|"activates"| MetabolicSyndrome
    LRP2 -->|"associated_with"| Aging
    
    %% Cross-pathway interactions
    Inflammation -->|"promotes"| Neurodegeneration
    Ischemia -->|"leads_to"| Stroke
    Atherosclerosis -->|"causes"| Ischemia
    MetabolicSyndrome -->|"contributes_to"| Atherosclerosis
    MYC -->|"regulates"| Inflammation
    MAP1LC3B -->|"mediates"| Aging
    
    %% Styling
    style LRP2 fill:#006494
    style MAP1LC3B fill:#4a1a6b
    style MYC fill:#4a1a6b
    style Neurodegeneration fill:#ef5350
    style ALS fill:#ef5350
    style FTD fill:#ef5350
    style Inflammation fill:#ef5350
    style Autoimmune fill:#ef5350
    style Ischemia fill:#ef5350
    style Stroke fill:#ef5350
    style Atherosclerosis fill:#ef5350
    style MetabolicSyndrome fill:#5d4400
    style Aging fill:#5d4400

Outgoing (168)

Target	Relation	Type	Str
Pulmonary Arterial Hypertension	involved_in	disease	0.85
Pulmonary Arterial Hypertension	implicated_in	disease	0.80
Heart Failure	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Hypertension	activates	disease	0.65
Autoimmune	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Ftd	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	activates	disease	0.65
Autoimmune	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	activates	disease	0.65
Heart Failure	activates	disease	0.65
ALS	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Stroke	regulates	disease	0.65
ALS	regulates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Lysosomal Degradation	associated_with	pathway	0.60
MITOCHONDRIA	activates	gene	0.60
RAS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
App	associated_with	protein	0.60
NADH	regulates	gene	0.60
MTORC1	regulates	gene	0.60
ATG	regulates	gene	0.60
ATP	regulates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
MTOR	activates	entity	0.60
MYC	activates	entity	0.60
PIK3C3	activates	entity	0.60
PPARA	activates	entity	0.60

Incoming (99)

Source	Relation	Type	Str
LDL	activates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
LRP8	associated_with	gene	0.60
LRP5	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LRP1	contributes_to	gene	0.60
PIK3C3	regulates	gene	0.60
RPS6	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MTOR	regulates	gene	0.60
LAMP1	regulates	gene	0.60
MYC	regulates	gene	0.60
PPARG	regulates	gene	0.60
RUBCN	regulates	gene	0.60
EGFR	regulates	gene	0.60
LRP1B	associated_with	gene	0.60
PAH	associated_with	gene	0.60
LRP4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
PAH	activates	gene	0.60
ACTB	activates	entity	0.60
CAT	activates	entity	0.60
CTSD	activates	entity	0.60
EGFR	activates	entity	0.60
EIF4EBP1	activates	entity	0.60
LAMP1	activates	entity	0.60
APOPTOSIS	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
MYELIN	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CPT1A	regulates	gene	0.60
APOER2	associated_with	gene	0.60
WNT	associated_with	gene	0.60
ATG	activates	gene	0.60
ATP	activates	gene	0.60
CPT1A	activates	gene	0.60
AMPK	activates	gene	0.60
GFP	activates	gene	0.60
ACTB	regulates	gene	0.60
GUSB	activates	gene	0.60
HEXB	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-independent neuronal protection via cystatin-C/LRP2 si	0.410	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity