gene

HSPA8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

499Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

HSPA8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Als, Alzheimer. Connected to 236 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPA8
Full Name	Heat Shock Protein Family A (Hsp70) Member 8
Chromosome	9q33.3
Function	Hsc70 participates in multiple cellular processes:
Molecular Weight	71 kDa
Amino Acids	646 aa
Pathways	Autophagy
UniProt ID	[P11142](https://www.uniprot.org/uniprot/P11142)
Ensembl ID	ENSG00000143371
GeneCards	HSPA8
Human Protein Atlas	HSPA8
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Atherosclerosis, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, ALPHA-SYNUCLEIN, ALS, AMPK, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections	499 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HSPA8 Gene

gene · 1229 words

→

Pathway Diagram

flowchart TD
    HSPA8["HSPA8
(Heat Shock Protein 8)"]
    
    %% Protein Quality Control Pathway
    HSPA8 -->|"chaperone activity"| ProteinFolding["Protein Folding
 and Quality Control"]
    ProteinFolding -->|"maintains"| CellularHomeostasis["Cellular
Homeostasis"]
    
    %% Autophagy Pathway
    HSPA8 -->|"activates"| ATG12["ATG12
(Autophagy)"]
    HSPA8 -->|"interacts with"| BECN1["BECN1
(Beclin-1)"]
    ATG12 -->|"promotes"| Autophagy["Autophagy
Activation"]
    BECN1 -->|"initiates"| Autophagy
    
    %% Lysosomal Pathway
    HSPA8 -->|"associated with"| MCOLN1["MCOLN1
(Mucolipin-1)"]
    HSPA8 -->|"regulates"| CTSB["CTSB
(Cathepsin B)"]
    MCOLN1 -->|"controls"| LysosomalFunction["Lysosomal
Function"]
    CTSB -->|"degrades"| LysosomalFunction
    
    %% Neurodegeneration Diseases
    HSPA8 -->|"contributes to"| ALS["Amyotrophic
Lateral Sclerosis"]
    HSPA8 -->|"associated with"| PD["Parkinson's
Disease"]
    HSPA8 -->|"linked to"| HD["Huntington's
Disease"]
    
    %% Key Protein Interactions
    HSPA8 -->|"interacts with"| SOD1["SOD1
(Superoxide Dismutase)"]
    HSPA8 -->|"regulates"| TARDBP["TARDBP
(TDP-43)"]
    SOD1 -->|"mutated in"| ALS
    TARDBP -->|"aggregates in"| ALS
    
    %% Cellular Stress Response
    HSPA8 -->|"activates"| CALCINEURIN["Calcineurin
(Phosphatase)"]
    CALCINEURIN -->|"regulates"| StressResponse["Cellular Stress
Response"]
    
    %% Outcomes
    Autophagy -->|"prevents"| ProteinAggregation["Protein
Aggregation"]
    LysosomalFunction -->|"clears"| ProteinAggregation
    ProteinAggregation -->|"leads to"| Neurodegeneration["Neurodegeneration"]
    
    %% Styling
    style HSPA8 fill:#006494
    style ProteinFolding fill:#1b5e20
    style Autophagy fill:#1b5e20
    style LysosomalFunction fill:#1b5e20
    style CellularHomeostasis fill:#1b5e20
    style ALS fill:#ef5350
    style PD fill:#ef5350
    style HD fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style ProteinAggregation fill:#ef5350
    style ATG12 fill:#4a1a6b
    style BECN1 fill:#4a1a6b
    style SOD1 fill:#4a1a6b
    style TARDBP fill:#4a1a6b
    style CALCINEURIN fill:#4a1a6b
    style StressResponse fill:#5d4400

Outgoing (282)

Target	Relation	Type	Str
Proteostasis	associated_with	process	0.95
Dendrite Proteostasis	involved_in	process	0.95
Motor Neurons	expressed_in	cell_type	0.92
Hippocampal Neurons	expressed_in	cell_type	0.90
Neurodegeneration Prevention	protects_against	phenotype	0.85
Chaperone-Mediated Autophagy	involved_in	pathway	0.85
Protein Folding	involved_in	process	0.85
CAV1	degrades	protein	0.80
Wnt/β-Catenin Signaling	activates	pathway	0.80
TOLLIP	interacts_with	protein	0.70
PRRSV	associated_with	entity	0.70
TMEM63A	interacts_with	protein	0.70
VCP	interacts_with	protein	0.70
DERL1	interacts_with	protein	0.70
oxidative stress response	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
Parkinson's disease	activates	disease	0.70
Stroke	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Infection	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Hypertension	expressed_in	disease	0.65
Ms	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Tumor	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60

Incoming (217)

Source	Relation	Type	Str
Proteotoxic Stress	upregulates	process	0.90
Motor Neurons	expressed_in	cell_type	0.90
FUS	regulates	gene	0.90
FERRITINH	binds	protein	0.80
ATG	activates	gene	0.70
rapamycin	targets	drug	0.70
DNA	activates	gene	0.60
GENES	activates	gene	0.60
RNA	associated_with	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
MIRNAS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ACAT1	activates	gene	0.60
CREB	activates	gene	0.60
GSK3	activates	gene	0.60
BAG3	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
MAPK14	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
HDAC6	activates	entity	0.60
HSP70	activates	entity	0.60
CBP	activates	gene	0.60
BAG3	regulates	gene	0.60
CALR	regulates	gene	0.60
GR	regulates	gene	0.60
HSP70	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
BAG3	interacts_with	gene	0.60
HSPA1A	causes	gene	0.60
CYP3A4	activates	gene	0.60
ACAT1	associated_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning HSPA8 in their description or question text

No additional research found