gene

RPS6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene page for RPS6 (Ribosomal Protein S6), a component of the 40S ribosomal subunit, substrate of S6 kinases, and associated with Noonan syndrome, cancer, and mTOR signaling.

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🧬 Gene Info

Gene Symbol	RPS6
Aliases	Ribosomal Protein S6
Chromosome	9p21.1
Function	encodes a protein of 249 amino acids.
Primary Expression	neurons and glial cells
Molecular Weight	28.7 kDa
Amino Acids	249 aa
Pathways	mTOR signaling, mTOR pathway, mTOR
Ensembl ID	ENSG00000143977
GeneCards	RPS6
Human Protein Atlas	RPS6
Associated Diseases	AD, ADH, AMI, Cancer, disease, Ischemia
Known Drugs/Compounds	rapamycin
Interactions	AKT, AKT1, APOE4, ATG, ATP, BECN1
KG Connections	213 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    RPS6["RPS6"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    RPS6["RPS6"] -->|"regulates"| Ischemia["Ischemia"]
    RPS6["RPS6"] -->|"regulates"| Ms["Ms"]
    RPS6["RPS6"] -->|"associated with"| Metabolic_Syndrome["Metabolic Syndrome"]
    RPS6["RPS6"] -->|"activates"| Lysosomal_Degradation["Lysosomal Degradation"]
    RPS6["RPS6"] -->|"regulates"| Mtor["Mtor"]
    RPS6["RPS6"] -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
    RPS6["RPS6"] -->|"regulates"| Autophagy["Autophagy"]
    RPS6["RPS6"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    RPS6["RPS6"] -->|"regulates"| MTOR["MTOR"]
    RPS6["RPS6"] -->|"regulates"| CTSD["CTSD"]
    RPS6["RPS6"] -->|"regulates"| LAMP1["LAMP1"]
    style RPS6 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Metabolic_Syndrome fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Lysosomal_Degradation fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Lipid_Metabolism fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style MAP1LC3B fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MTOR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CTSD fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LAMP1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (135)

Target	Relation	Type	Str
protein synthesis	regulates	process	0.90
APOE	suppresses	gene	0.85
Carcinoma	activates	disease	0.75
AKT	associated_with	gene	0.70
Lysosomal Degradation	associated_with	pathway	0.70
PI3K	associated_with	gene	0.70
AKT1	activates	gene	0.70
MTORC1	regulates	gene	0.70
TSC2	activates	gene	0.70
Mtor	regulates	pathway	0.70
MTOR	regulates	gene	0.70
Mtor	associated_with	pathway	0.70
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Cancer	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Lysosomal Degradation	activates	pathway	0.60
MTOR	associated_with	gene	0.60
Autophagy	regulates	pathway	0.60
NADH	regulates	gene	0.60
ATP	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
RAS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
AND	regulates	gene	0.60
Epithelial	regulates	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
NAMPT	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
Lipid Metabolism	activates	pathway	0.60
CTCF	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PI3K	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
FOXO1	activates	gene	0.60
AKT	activates	gene	0.60
MYC	activates	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60

Incoming (78)

Source	Relation	Type	Str
MTOR	phosphorylates	gene	0.95
RPS6KB1	phosphorylates	protein	0.90
Hearing Loss	phosphorylates	phenotype	0.88
HEARING_LOSS	activates	phenotype	0.80
APOE4	activates	gene	0.60
ATP	activates	gene	0.60
CPT1A	activates	gene	0.60
MTORC1	activates	gene	0.60
NADH	activates	gene	0.60
RAS	activates	gene	0.60
rapamycin	targets	drug	0.60
ACTB	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
ATG	activates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
LRP2	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MYC	regulates	gene	0.60
MTOR	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
EGFR	regulates	gene	0.60
PPARG	regulates	gene	0.60
LAMP1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
SREBF1	regulates	gene	0.60
ACTB	activates	entity	0.60
CAT	activates	entity	0.60
CTSD	activates	entity	0.60
EGFR	activates	entity	0.60
EIF4EBP1	activates	entity	0.60
LAMP1	activates	entity	0.60
LRP2	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MTOR	activates	entity	0.60
MYC	activates	entity	0.60
PIK3C3	activates	entity	0.60
PPARA	activates	entity	0.60
PPARG	activates	entity	0.60
PPARGC1A	activates	entity	0.60
RAB7A	activates	entity	0.60
MITOCHONDRIA	activates	gene	0.60
CPT1A	regulates	gene	0.60
LC3B	regulates	gene	0.60
LC3B	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPS6 in their description or question text

No additional research found

RPS6

Understanding Entity Pages

Summary

Wiki Pages (6)

RPS6 Gene

RPS6KA1 — Ribosomal Protein S6 Kinase A1

RPS6KA2 — Ribosomal Protein S6 Kinase A2

RPS6KB1 Gene

p70S6K (RPS6KB1) Protein

RPS6KB2 - Ribosomal Protein S6 Kinase B2