gene

PPARA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPARA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

543Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

PPARA is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ADH, AMI. Connected to 280 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPARA
Chromosome	22q13.31
Protein Type	Transcription Factor
Function	encodes a ligand-activated transcription factor belonging to the nuclear receptor superfamily.
Primary Expression	tissues with high fatty acid catabolism, including liver, heart, skeletal muscle, and kidney
Amino Acids	468 aa
Exons	8
Pathways	Akt, Autophagy, Mapk, Mtor, Sphingolipid
Ensembl ID	ENSG00000186951
GeneCards	PPARA
Human Protein Atlas	PPARA
Associated Diseases	AD, ADH, Als, Alzheimer disease, Alzheimer's disease, AMI
Known Drugs/Compounds	Bezafibrate, gemfibrozil, rapamycin, Wy14643
Interactions	ACACA, ACOX1, Adiponectin, ADIPOQ, AKT1, ALDH2
SciDEX Hypotheses	Palmitoylethanolamide-Based Endocannabinoid Therap Cell-Type Specific Metabolic Reprogramming
KG Connections	543 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ppara

gene · 1210 words

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Pathway Diagram

flowchart TD
    PPARGC1A["PPARGC1A
PGC-1alpha
Master Regulator"]
    PPARA["PPARA
Peroxisome Proliferator
Activated Receptor alpha"]
    TFEB["TFEB
Transcription Factor EB
Autophagy Master Regulator"]
    autophagy["Autophagy
Cellular Clearance
Process"]
    MAP1LC3B["MAP1LC3B
LC3B
Autophagosome Marker"]
    APP["APP
Amyloid Precursor
Protein"]
    Abeta["Abeta
Amyloid Beta
Plaques"]
    gemfibrozil["Gemfibrozil
PPARA Agonist
Drug"]
    Wy14643["Wy-14643
PPARA Agonist
Compound"]
    JMJD3["JMJD3
Histone Demethylase
Epigenetic Regulator"]
    alzheimers["Alzheimer's Disease
Neurodegeneration"]
    inflammation["Neuroinflammation
Pathological Process"]
    metabolism["Metabolic
Dysfunction"]
    anxiety["Anxiety
Behavioral Symptoms"]

    PPARGC1A -->|"activates"| PPARA
    gemfibrozil -->|"activates"| PPARA
    Wy14643 -->|"activates"| PPARA
    JMJD3 -->|"interacts with"| PPARA
    
    PPARA -->|"regulates"| TFEB
    PPARA -->|"activates"| MAP1LC3B
    TFEB -->|"promotes"| autophagy
    MAP1LC3B -->|"facilitates"| autophagy
    
    PPARA -->|"regulates"| APP
    APP -->|"produces"| Abeta
    autophagy -->|"degrades"| Abeta
    
    PPARA -->|"prevents"| alzheimers
    PPARA -->|"reduces"| inflammation
    PPARA -->|"inhibits"| anxiety
    
    Abeta -->|"causes"| alzheimers
    inflammation -->|"contributes to"| alzheimers
    metabolism -->|"affects"| alzheimers

    style PPARA fill:#006494
    style TFEB fill:#1b5e20
    style autophagy fill:#1b5e20
    style MAP1LC3B fill:#1b5e20
    style gemfibrozil fill:#1b5e20
    style Wy14643 fill:#1b5e20
    style PPARGC1A fill:#4a1a6b
    style JMJD3 fill:#4a1a6b
    style alzheimers fill:#ef5350
    style Abeta fill:#ef5350
    style inflammation fill:#ef5350
    style APP fill:#ef5350
    style anxiety fill:#5d4400
    style metabolism fill:#5d4400

Outgoing (337)

Target	Relation	Type	Str
Respiratory Capacity	promotes	phenotype	0.90
Phagocytosis	activates	process	0.90
lipid metabolism	involved_in	process	0.90
oxidative phosphorylation	upregulates	pathway	0.88
Lipid Oxidation	regulates	process	0.85
Alzheimer disease	implicated_in	disease	0.80
PPARG	associated_with	gene	0.80
autophagy	regulates	process	0.70
AMPK	therapeutic_target	gene	0.70
Alzheimer's disease	protects_against	disease	0.70
Lysosomal Degradation	associated_with	pathway	0.70
TFEB	regulates	protein	0.70
MAP1LC3B	activates	protein	0.70
Aβ	regulates	protein	0.70
PPARG	interacts_with	gene	0.70
RAS	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
APP	regulates	gene	0.70
Neurodegeneration	regulates	disease	0.65
Nafld	regulates	disease	0.65
Als	activates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Glioma	activates	disease	0.65
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Autoimmune	associated_with	disease	0.65
Diabetes	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Huntington	activates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	activates	disease	0.65
Hepatitis	activates	disease	0.65
Ms	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Hepatitis	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (206)

Source	Relation	Type	Str
Bezafibrate	activates	drug	0.95
PPARGC1A	activates	gene	0.90
PPARGC1A	interacts_with	gene	0.80
Wy14643	activates	drug	0.70
ATG	activates	gene	0.70
MTORC1	activates	gene	0.70
rapamycin	targets	drug	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
gemfibrozil	activates	drug	0.70
JMJD3	interacts_with	protein	0.64
RPS6	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
FOXO1	interacts_with	gene	0.60
TGFB1	therapeutic_target	gene	0.60
SQSTM1	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
MYC	regulates	gene	0.60
MAP3K5	interacts_with	gene	0.60
CAT	regulates	gene	0.60
APP	activates	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
GLP1R	interacts_with	gene	0.60
EGFR	regulates	gene	0.60
PIK3CA	interacts_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
MMP9	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
LAMP1	regulates	gene	0.60
P62	interacts_with	gene	0.60
PPARG	regulates	gene	0.60
LRP2	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
PPARGC1A	regulates	gene	0.60
RUBCN	regulates	gene	0.60
CTSD	regulates	gene	0.60
PLIN2	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
RAB7A	regulates	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Palmitoylethanolamide-Based Endocannabinoid Therapy	0.919	-	Blood-brain barrier tight junction disru
Cell-Type Specific Metabolic Reprogramming	0.643	neurodegeneration	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

closed · Rounds: 4 · Score: 0.76 · 2026-04-23

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

closed · Rounds: 7 · Score: 0.87 · 2026-04-16