gene

SREBF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SREBF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

596Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SREBF1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ADH, ALS. Connected to 279 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SREBF1 (SREBP1)
Full Name	Sterol Regulatory Element Binding Transcription Factor 1
Chromosome	17p11.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	NF-κB
UniProt ID	P36956
NCBI Gene ID	6720
Ensembl ID	ENSG00000172318
OMIM	184756
SREBP1a	More potent transcription factor, wider target gene range
SREBP1c	Primarily regulates fatty acid synthesis, insulin-responsive
Sterol-sensing domain	Responds to sterol levels
C-terminal regulatory domain	Interactions with SCAP and INSIG
Insulin signaling	PI3K/Akt pathway activates SREBP1c
Glucose	ChREBP cooperation
Associated Diseases	AD, ADH, Aging, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	A2M, ACACA, ACOX1, Adiponectin, ADIPOQ, ALDH2
KG Connections	596 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SREBF1 — AlphaFold P36956 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SREBF1 Gene

gene · 1010 words

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Pathway Diagram

graph TD
    SREBF1["SREBF1"] -->|"Regulates"| LDLR["LDLR"]
    SREBF1["SREBF1"] -->|"Activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    SREBF1["SREBF1"] -->|"Regulates"| Ischemia["Ischemia"]
    SREBF1["SREBF1"] -->|"Regulates"| Ms["Ms"]
    SREBF1["SREBF1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    SREBF1["SREBF1"] -->|"Interacts With"| Tumor["Tumor"]
    SREBF1["SREBF1"] -->|"Interacts With"| Als["Als"]
    SREBF1["SREBF1"] -->|"Interacts With"| Hepatitis["Hepatitis"]
    ACTB["ACTB"] -->|"Regulates"| SREBF1["SREBF1"]
    PPARA["PPARA"] -->|"Regulates"| SREBF1["SREBF1"]
    CAT["CAT"] -->|"Regulates"| SREBF1["SREBF1"]
    SQSTM1["SQSTM1"] -->|"Regulates"| SREBF1["SREBF1"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| SREBF1["SREBF1"]
    style SREBF1 fill:#8d4900,color:#e0e0e0
    style LDLR fill:#8d4900,color:#e0e0e0
    style Metabolic_Syndrome fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style ACTB fill:#8d4900,color:#e0e0e0
    style PPARA fill:#8d4900,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0
    style RPS6KB1 fill:#8d4900,color:#e0e0e0

Outgoing (317)

Target	Relation	Type	Str
lipid metabolism	regulates	process	0.95
Lipid Metabolism	regulates	process	0.90
LDLR	regulates	gene	0.85
tumor progression	drives	phenotype	0.85
Als	regulates	disease	0.75
Cancer	regulates	disease	0.75
Lysosomal Degradation	associated_with	pathway	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Lysosomal Degradation	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
ALZHEIMER'S DISEASE	associated_with	entity	0.70
Diabetes	associated_with	disease	0.65
Als	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Atherosclerosis	degrades	disease	0.65
Ferroptosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Diabetes	regulates	disease	0.65
Hepatitis	interacts_with	disease	0.65
Atherosclerosis	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Nafld	regulates	disease	0.65
Ms	regulates	disease	0.65
ALS	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ischemia	regulates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Obesity	activates	disease	0.65
Tumor	activates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Cancer	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Fatty Liver	activates	disease	0.65
ER stress	activates	process	0.60
Adiponectin	interacts_with	protein	0.60
CYP46A1	degrades	gene	0.60
PSEN1	degrades	gene	0.60
GSK3B	degrades	gene	0.60

Incoming (279)

Source	Relation	Type	Str
PRMT1	interacts_with	gene	0.95
PRMT1	phosphorylates	gene	0.90
ATG	activates	gene	0.70
rapamycin	targets	drug	0.70
MTORC1	activates	gene	0.70
RAS	activates	gene	0.70
NADH	regulates	gene	0.60
ATP	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
TFCP2	interacts_with	gene	0.60
CH25H	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APOD	regulates	gene	0.60
FURIN	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
TFCP2	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
CH25H	transports	gene	0.60
APOD	transports	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
GENES	contributes_to	gene	0.60
LDL	contributes_to	gene	0.60
AUTOPHAGY	activates	gene	0.60
CH25H	degrades	gene	0.60
ALZHEIMER	degrades	gene	0.60
CPT1A	activates	gene	0.60
NADH	activates	gene	0.60
LRP1	transports	gene	0.60
CREB	interacts_with	gene	0.60
MTORC1	regulates	gene	0.60
PSEN1	transports	gene	0.60
TAU	transports	gene	0.60
APOC1	transports	gene	0.60
SNARE	activates	gene	0.60
ACACA	activates	gene	0.60
NR2F1	regulates	gene	0.60
SREBF2	associated_with	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SQSTM1	activates	gene	0.60
MAPT	activates	gene	0.60
LC3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SREBF1 in their description or question text

No additional research found