gene

PPARGC1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPARGC1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

980Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

4Experiments

5Debates

Summary

PPARGC1A is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Als, Alzheimer's disease. Connected to 505 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPARGC1A
Full Name	PPARG Coactivator 1 Alpha
Chromosome	4p15.31
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	PPARGC1A encodes PGC-1α (PPAR gamma coactivator 1-alpha), a transcriptional coactivator that serves as a master regulator of mitochondrial biogenesis and cellular energy metabolism.
Mechanism of Action	Small molecule modulator of transcriptional coactivator function
Primary Expression	tissues with high metabolic demand: - Brain: Neurons (especially in substantia nigra, hippocampus), [astrocytes](/entities/as
Druggability	Low (0.43)
Clinical Stage	Approved
Pathways	Apoptosis, Autophagy, Cell Cycle, Er Stress, Ferroptosis
UniProt ID	Q9UBK2
NCBI Gene ID	10891
Ensembl ID	ENSG00000109819
OMIM	604517
GeneCards	PPARGC1A
Human Protein Atlas	PPARGC1A
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, athletic_performance
Known Drugs/Compounds	Aloe-emodin, glitazones, Kaixinsan, Lactiplantibacillus plantarum SG5, metformin, METFORMIN
Interactions	AKT1, ALS, AMPK, amyloid beta, amyloid-beta, amyotrophic lateral sclerosis
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito
KG Connections	978 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPARGC1A — AlphaFold Q9UBK2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PPARGC1A["PPARGC1A"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PPARGC1A["PPARGC1A"] -->|"interacts"| PRKAA1["PRKAA1"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| SLC16A2["SLC16A2"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| RELN["RELN"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| MAP6["MAP6"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| HCN1["HCN1"]
    PRKAA1_1["PRKAA1"] -->|"interacts"| PPARGC1A["PPARGC1A"]
    FOXP3["FOXP3"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    TNFA["TNFA"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    style PPARGC1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (609)

Target	Relation	Type	Str
PGC1A	encodes	protein	0.95
Mitochondrial Biogenesis	regulates	process	0.95
Parvalbumin Interneuron Maturation	mediates	process	0.95
mitochondrial biogenesis	regulates	pathway	0.95
Oxidative Phosphorylation	mediates	pathway	0.95
mitochondrial biogenesis	promotes	process	0.95
Alzheimer'S Disease	downregulates	disease	0.95
Mitochondrial Biogenesis	mediates	process	0.95
Mitochondrial Biogenesis	involved_in	process	0.95
BACE1	regulates	gene	0.95
Parvalbumin interneuron electrophysiological properties	drives	phenotype	0.90
Parvalbumin interneuron structural development	promotes	phenotype	0.90
fatty acid oxidation	associated_with	pathway	0.90
cancer metastasis	associated_with	disease	0.90
abdominal aortic aneurysm	protects_against	disease	0.90
PPARA	activates	gene	0.90
autophagy	activates	pathway	0.90
Inflammatory Cytokines	regulates	process	0.90
SQSTM1	regulates	protein	0.90
NRF2	activates	protein	0.90
Cancer Cell Invasion	contributes_to	phenotype	0.90
Metastasis	contributes_to	process	0.90
PPARD	activates	gene	0.90
depression	protects_against	disease	0.90
Reactive Oxygen Species	regulates	process	0.90
lipid droplet accumulation	inhibits	phenotype	0.90
lipid metabolism	regulates	pathway	0.90
kynurenine aminotransferases	contributes_to	protein	0.90
ATP production	contributes_to	pathway	0.90
oxidative phosphorylation	associated_with	pathway	0.90
Alzheimer's Disease	therapeutic_target	disease	0.90
Mitochondrial Biogenesis	activates	process	0.90
Pv+ Interneuron	regulates	cell_type	0.90
amyloid-beta	inhibits	protein	0.90
senescence	inhibits	phenotype	0.90
Amyloid-Beta	downregulates	protein	0.90
Reactive Oxygen Species Synthesis	regulates	process	0.90
Metabolic Processes	regulates	process	0.85
Amyloidosis	downregulates	disease	0.85
Hepatocellular Carcinoma Progression	inhibits	disease	0.85
NRF	interacts_with	protein	0.85
Terminal Differentiation	involved_in	process	0.85
Synaptic Function	regulates	phenotype	0.85
Metabolic Features	regulates	phenotype	0.85
Structural Properties	regulates	phenotype	0.85
Electrophysiological Properties	regulates	phenotype	0.85
WNT/β-Catenin Signaling	inhibits	pathway	0.85
Mitochondrial Pool	associated_with	phenotype	0.85
Electrophysiological Maturation	promotes	phenotype	0.85
Synaptic Maturation	promotes	phenotype	0.85

Incoming (371)

Source	Relation	Type	Str
h-immunity-6e54942b	relates_to	hypothesis	0.00
genes-ppargc1a	linked_to	wiki_page	1.00
IRE1A	degrades	protein	0.95
Neuronal activity	activates	process	0.90
h-b0cda336	targets	hypothesis	0.90
h-76888762	targets	hypothesis	0.90
SIRT1	modifies	protein	0.90
SIRT1	interacts_with	protein	0.90
TFEB	activates	gene	0.90
h-4c3210de	targets_gene	hypothesis	0.90
CREB1	upregulates	gene	0.85
TFEB	upregulates	protein	0.85
CLU	associated_with	protein	0.85
PRKAA2	activates	gene	0.85
WTAP	downregulates	gene	0.85
METTL3	downregulates	gene	0.85
ASPSCR1	binds	protein	0.85
exercise	activates	phenotype	0.80
Prkaa2	activates	protein	0.80
Metformin	upregulates	drug	0.80
aging	inhibits	phenotype	0.80
IRE1A	inhibits	gene	0.72
FBXW7	inhibits	gene	0.70
AMPK	regulates	protein	0.70
MPTP	inhibits	drug	0.70
P62	associated_with	gene	0.70
CTSD	regulates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
CAT	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
ACTB	regulates	gene	0.70
CANCER	regulates	gene	0.70
metformin	targets	drug	0.70
ATG	activates	gene	0.70
Lactiplantibacillus plantarum SG5	activates	drug	0.70
GLP-1	regulates	protein	0.70
Aloe-emodin	activates	drug	0.70
Kaixinsan	activates	drug	0.70
amyloid beta	inhibits	protein	0.70
PPARG	regulates	protein	0.70
PPARγ	activates	protein	0.70
piperine	activates	drug	0.70
glitazones	activates	drug	0.70
rapamycin	targets	drug	0.70
CLU	interacts_with	gene	0.64
THYROID_HORMONE	activates	drug	0.64
TFEB	regulates	gene	0.64
METTL3	inhibits	gene	0.64
METFORMIN	activates	drug	0.64
WTAP	inhibits	gene	0.64

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Perforant Path Presynaptic Terminal Protection Strategy	0.696	neurodegeneration	Selective vulnerability of entorhinal co
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PGC-1α knockout effects on PV+ interneuron maturation	validation		0.900	0.00	PGC-1α knockout mice	proposed	N/A
PGC-1α expression analysis during PV+ interneuron development	exploratory		0.800	0.00	mouse cortex	proposed	N/A
Activity-dependent regulation of PGC-1α in PV+ interneurons	exploratory		0.800	0.00	mouse cortical neurons	proposed	N/A
Metabolic Pathway-Targeted Therapy in ALS	clinical	ALS	0.400	0.50	human	proposed	$6,550,000

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
A postnatal molecular switch drives activity-dependent maturation of parvalbumin [PMID:40669459]	Moissidis M, Abbasova L, Selten M, Alis	Cell	2025	1
The Role of PGC1α in Alzheimer's Disease and Therapeutic Interventions. [PMID:34071270]	Mota BC, Sastre M	Int J Mol Sci	2021	1
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl [PMID:33686286]	Habtemichael EN, Li DT, Camporez JP, Wes	Nat Metab	2021	1
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithel [PMID:31944172]	Matsuda J, Takahashi A, Takabatake Y, Sa	Autophagy	2020	1
Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586]	Prashantha Kumar BR, Kumar AP, Jose JA,	Neurochem Int	2020	1
Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614]	["Jin H", "Xue B", "Chen X", "Ma T", "Ma	Environmental pollution (Barki	2025	0
Lipidomic and Transcriptomic Reveals Variations in Lipid Deposition During Goose [PMID:41300406]	Zhang Q, Bai C, Zhang M, Yue B, Zhang J,	Biology	2025	0
Blueberry anthocyanins ameliorate arsenic-induced cognitive impairment in rats: [PMID:40663938]	Ma X, Liu Y, Ding B, Liu Y, Zhang Y, Wan	Phytomedicine : international	2025	0
Deciphering the PGC-1α-TFAM Axis in Parkinson's Disease (PD) - A Mechanism Appro [PMID:41454214]	Iyer M, Kinoshita M, Reddy DH, Babu HWS,	Molecular neurobiology	2025	0
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice [PMID:40220403]	Fan X, Wei X, Wang W, Chai W, Xiao J, Ha	Phytomedicine : international	2025	0
Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 path [PMID:40646155]	["Yang C", "Yu H", "Zhou L", "Su H", "Li	Scientific reports	2025	0
Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 [PMID:37989471]	["Guo B", "Zheng C", "Cao J", "Luo F", "	Journal of advanced research	2024	0
Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG [PMID:27102200]	["Kopp T", "Jensen D", "Ravn-Haren G", "	BMC cancer	2016	0
Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene [PMID:18954260]	["Mallon P", "Sedwell R", "Rogers G", "N	The Journal of infectious dise	2008	0

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PPARGC1A in their description or question text

No additional research found

PPARGC1A

Understanding Entity Pages

Summary

Wiki Pages (3)

PPARGC1A Gene

PGC-1α (PPARGC1A)

PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration

Pathway Diagram

Outgoing (609)

Incoming (371)

Targeting Hypotheses (2)

Mentioning Analyses (5)

Can circadian interventions reverse microglial priming independent of sleep disr

Immune atlas neuroinflammation analysis in neurodegeneration

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Digital biomarkers and AI-driven early detection of neurodegeneration

Selective vulnerability of entorhinal cortex layer II neurons in AD

Experiments (4)

Related Papers (14)

Debates (5)

Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique

Can circadian interventions reverse microglial priming independent of sleep disr

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia s

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

Related Research