Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPITHELIAL CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | EPITHELIAL CELL |
graph TD
EPITHELIAL_CELL["EPITHELIAL CELL"]
MTOR["MTOR"] -->|"expressed in"| EPITHELIAL_CELL
MYC["MYC"] -->|"expressed in"| EPITHELIAL_CELL
EGFR["EGFR"] -->|"expressed in"| EPITHELIAL_CELL
MTORC1["MTORC1"] -->|"expressed in"| EPITHELIAL_CELL
RPS6["RPS6"] -->|"expressed in"| EPITHELIAL_CELL
CTSD["CTSD"] -->|"expressed in"| EPITHELIAL_CELL
ATG["ATG"] -->|"expressed in"| EPITHELIAL_CELL
NADH["NADH"] -->|"expressed in"| EPITHELIAL_CELL
SQSTM1["SQSTM1"] -->|"expressed in"| EPITHELIAL_CELL
PPARA["PPARA"] -->|"expressed in"| EPITHELIAL_CELL| Target | Relation | Type | Str |
|---|---|---|---|
| Myofibroblast | associated_with | cell_type | 0.75 |
| Cystic Fibrosis | activates | disease | 0.50 |
| ENDOPLASMIC RETICULUM | activates | concept | 0.50 |
| Sepsis | activates | disease | 0.50 |
| IL-17 | activates | concept | 0.50 |
| CELL DEATH | inhibits | concept | 0.50 |
| Pi3K/Akt | inhibits | pathway | 0.50 |
| Nephropathy | inhibits | disease | 0.50 |
| PI3K/AKT PATHWAY | inhibits | concept | 0.50 |
| QUERCETIN | inhibits | concept | 0.50 |
| Type 2 Diabetes | activates | disease | 0.50 |
| QUERCETIN | activates | concept | 0.50 |
| Crohn Disease | activates | disease | 0.50 |
| QUERCETIN | protects_against | concept | 0.50 |
| Dendritic Cell | activates | cell_type | 0.50 |
| CYP1A1 | activates | concept | 0.50 |
| DNA DAMAGE | activates | concept | 0.50 |
| COLORECTAL CANCER | activates | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| disease | activates | disease | 0.50 |
| AKT1S1 | activates | concept | 0.50 |
| Microrna | activates | pathway | 0.50 |
| Inflammatory Bowel Disease | activates | disease | 0.50 |
| Reactive Oxygen Species | activates | process | 0.50 |
| NUCLEUS | activates | concept | 0.50 |
| NADH | activates | concept | 0.50 |
| INSULIN | activates | concept | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| PEROXISOME | activates | concept | 0.50 |
| GENE EXPRESSION | interacts_with | concept | 0.50 |
| Nephropathy | activates | disease | 0.50 |
| MACROPHAGES | regulates | concept | 0.50 |
| T CELLS | regulates | concept | 0.50 |
| CYP2E1 | expressed_in | concept | 0.50 |
| Fibroblast | activates | cell_type | 0.50 |
| Pulmonary Fibrosis | activates | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MESENCHYMAL STEM CELL | interacts_with | entity | 0.90 |
| Mesenchymal Stem Cell | mediates | cell_type | 0.88 |
| RIPK2 | expressed_in | gene | 0.55 |
| PYCARD | expressed_in | gene | 0.55 |
| NOD2 | expressed_in | gene | 0.55 |
| BRG1 | expressed_in | gene | 0.55 |
| MELK | expressed_in | gene | 0.55 |
| SMARCA4 | expressed_in | gene | 0.55 |
| TNFA | expressed_in | gene | 0.55 |
| NLRP3 | expressed_in | gene | 0.55 |
| BECLIN1 | expressed_in | gene | 0.55 |
| ASC | expressed_in | gene | 0.55 |
| RIPK3 | expressed_in | gene | 0.55 |
| SPTLC1 | expressed_in | gene | 0.55 |
| FGF | expressed_in | gene | 0.55 |
| CERS2 | expressed_in | gene | 0.55 |
| HO-1 | expressed_in | gene | 0.55 |
| VDR | expressed_in | gene | 0.55 |
| NRF2 | expressed_in | gene | 0.55 |
| FOXO3 | expressed_in | gene | 0.55 |
| SIRT1 | expressed_in | gene | 0.55 |
| LC3B | expressed_in | gene | 0.55 |
| NEURODEGENERATION | expressed_in | gene | 0.55 |
| PRESENILIN-1 | expressed_in | gene | 0.55 |
| PRESENILIN | expressed_in | gene | 0.55 |
| PSEN1 | expressed_in | gene | 0.55 |
| COX2 | expressed_in | gene | 0.55 |
| CPT1A | expressed_in | gene | 0.55 |
| AND | expressed_in | gene | 0.55 |
| MAO | expressed_in | gene | 0.55 |
| TREK-1 | expressed_in | gene | 0.55 |
| LCN2 | expressed_in | gene | 0.55 |
| PARKIN | expressed_in | gene | 0.55 |
| GSH | expressed_in | gene | 0.55 |
| SREBF1 | expressed_in | gene | 0.55 |
| AGING | expressed_in | gene | 0.55 |
| MITOCHONDRIA | expressed_in | gene | 0.55 |
| MAP1LC3B | expressed_in | gene | 0.55 |
| COFILIN | expressed_in | gene | 0.55 |
| STAT1 | expressed_in | gene | 0.55 |
| BCL-2 | expressed_in | gene | 0.55 |
| LRP2 | expressed_in | gene | 0.55 |
| ATP | expressed_in | gene | 0.55 |
| PPARG | expressed_in | gene | 0.55 |
| NOTCH1 | expressed_in | gene | 0.55 |
| NOTCH | expressed_in | gene | 0.55 |
| JAG1 | expressed_in | gene | 0.55 |
| DIO2 | expressed_in | gene | 0.55 |
| BLM | expressed_in | gene | 0.55 |
| TEAD1 | expressed_in | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EPITHELIAL CELL in their description or question text
No additional research found