protein

CREB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1884Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

CREB is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 570 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CREB
Function	Creb Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Primary Expression	hippocampus, cortex, prefrontal cortex, striatum, Prefrontal Cortex
Molecular Weight	37 kDa
Amino Acids	341 aa
Pathways	Methamphetamine Toxicity
GeneCards	CREB
Human Protein Atlas	CREB
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Cardiomyopathy, CHROMATIN REMODELING
Known Drugs/Compounds	EPIGALLOCATECHIN GALLATE, GENISTEIN, ketamine, Ketogenic Diet, LIRAGLUTIDE, memantine
Interactions	ABETA, ACAT1, ACHE, ACOX1, Actin, AD
KG Connections	1884 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CREB(["CREB"])
    BDNF(["BDNF"])
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    Als["Als"]
    Inflammation["Inflammation"]
    Oxidative_Stress["Oxidative Stress"]
    AKT(["AKT"])
    Depression["Depression"]
    Neurodegeneration["Neurodegeneration"]
    PKA(["PKA"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    AMPK(["AMPK"])
    APOPTOSIS(["APOPTOSIS"])
    Apoptosis["Apoptosis"]
    ERK(["ERK"])

    CREB -->|"activates"| BDNF
    CREB -->|"activates"| OXIDATIVE_STRESS
    CREB -->|"activates"| Als
    CREB -->|"activates"| Inflammation
    CREB -->|"activates"| Oxidative_Stress
    CREB -->|"activates"| AKT
    CREB -->|"activates"| Depression
    CREB -->|"activates"| Neurodegeneration
    CREB -->|"regulates"| BDNF
    PKA -->|"activates"| CREB
    CREB -->|"activates"| NEURODEGENERATION
    CREB -->|"activates"| AMPK
    CREB -->|"activates"| APOPTOSIS
    CREB -->|"activates"| Apoptosis
    CREB -->|"activates"| ERK

    style CREB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1239)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
AKT	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
Als	activates	disease	1.00
BDNF	activates	protein	1.00
Depression	activates	disease	0.95
Neurodegeneration	activates	disease	0.95
BDNF	upregulates	protein	0.90
BDNF-TrkB signaling	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
CREB signaling	participates_in	pathway	0.90
BDNF	regulates	protein	0.90
NEURODEGENERATION	activates	gene	0.90
AMPK	activates	gene	0.90
ERK	activates	gene	0.90
Apoptosis	activates	pathway	0.90
APOPTOSIS	activates	gene	0.90
DEPRESSION	activates	gene	0.90
Alzheimer	therapeutic_target	disease	0.85
Neuroinflammation	activates	disease	0.85
Alzheimer	activates	disease	0.85
neurotrophin signaling	participates_in	pathway	0.85
Cognitive Impairment	involved_in	phenotype	0.85
Traumatic Brain Injury	activates	disease	0.85
hippocampus	expressed_in	brain_region	0.80
Methamphetamine Toxicity	involved_in	mechanism	0.80
cortex	expressed_in	brain_region	0.80
VAMP8	regulates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
neurons	activates	cell_type	0.80
ALZHEIMER	therapeutic_target	gene	0.80
ALZHEIMER	activates	gene	0.80
ROS	activates	gene	0.80
GENES	activates	gene	0.80
SIRT1	activates	gene	0.80
TNF	activates	gene	0.80
MICROGLIA	activates	gene	0.80
Mapk	activates	pathway	0.80
Als	protects_against	disease	0.75
Alzheimer	inhibits	disease	0.75
Obesity	activates	disease	0.75
Neurodegeneration	protects_against	disease	0.75
Tumor	activates	disease	0.75
Stroke	activates	disease	0.75
PKA	activates	gene	0.75
Cognitive Performance	mediates	phenotype	0.75
Aging	activates	disease	0.75
BDNF_GENE	regulates	gene	0.72

Incoming (645)

Source	Relation	Type	Str
APOPTOSIS	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PKA	activates	protein	0.90
BDNF	activates	gene	0.90
Copper	suppresses	compound	0.90
ERK	phosphorylates	protein	0.90
Antidepressant Treatment	upregulates	process	0.90
Neuronal Activity	activates	process	0.88
GSK-3β	upstream_of	protein	0.88
Ketogenic Diet	activates	drug	0.85
CRTC2	interacts_with	protein	0.85
Pcs	modulates	compound	0.85
CAMK2	phosphorylates	gene	0.85
TRKB	phosphorylates	protein	0.85
ABETA	inhibits	protein	0.80
EPIGALLOCATECHIN GALLATE	targets	compound	0.80
GENISTEIN	targets	compound	0.80
SIGMAR1	regulates	gene	0.80
rapamycin	targets	drug	0.80
BDNF	treats	gene	0.80
APP	associated_with	gene	0.80
antidepressant treatments	upregulates	process	0.80
BDNF	interacts_with	gene	0.74
TAU	associated_with	protein	0.74
MTOR	activates	gene	0.74
BDNF	regulates	gene	0.70
BDNF	biomarker_for	gene	0.70
CGAS	interacts_with	gene	0.70
ATG7	activates	gene	0.70
CHOLINERGIC	inhibits	cell_type	0.70
ADORA2A	activates	gene	0.70
ACHE	expresses	gene	0.70
AMPK	protects_against	gene	0.70
BDNF	expressed_in	gene	0.70
CDK5	activates	gene	0.70
CDK5	inhibits	gene	0.70
ADORA2A	causes	gene	0.70
ATG5	activates	gene	0.70
ATG5	interacts_with	gene	0.70
CCL2	regulates	gene	0.70
KDM6A	interacts_with	gene	0.70
ATM	treats	gene	0.70
LIRAGLUTIDE	activates	drug	0.70
TNF-Α	activates	gene	0.70
MELATONIN	regulates	drug	0.70
ALS	stabilizes	disease	0.70
CBP	regulates	gene	0.70
Tirzepatide	activates	drug	0.70
ERK	activates	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signa	0.610	synaptic biology	What determines the selectivity of compl

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CREB in their description or question text

No additional research found

CREB

Understanding Entity Pages

Summary

Wiki Pages (13)

CREB Signaling in Neurodegeneration

CREB-independent Neuronal Survival Pathways

CREB Neurons

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

CREB5 — cAMP Responsive Element Binding Protein 5

CREB1 Protein

Pathway Diagram

Outgoing (1239)

Incoming (645)

Targeting Hypotheses (1)

Mentioning Analyses (3)

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

What neural circuits encode and maintain multi-generational migratory route memo

How does ADCY8 mechanistically regulate long-term memory formation in migratory

Experiments (0)

Related Papers (0)

Debates (3)

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

The study identifies ADCY8 as associated with migratory distance differences and

The paper describes memory-based migration routes maintained across generations

Related Research

CREB

Understanding Entity Pages

Summary

Wiki Pages (13)

CREB Signaling in Neurodegeneration

CREB-independent Neuronal Survival Pathways

CREB Neurons

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

CREB5 — cAMP Responsive Element Binding Protein 5

CREB1 Protein

CREBBP Protein

CREB1 Gene

CREB Protein

CREBBP Gene

CREB3 Gene

CREB5 Protein — cAMP Responsive Element Binding Protein 5

CREB3L1 Gene

Pathway Diagram

Outgoing (1239)

Incoming (645)

Targeting Hypotheses (1)

Mentioning Analyses (3)

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

What neural circuits encode and maintain multi-generational migratory route memo

How does ADCY8 mechanistically regulate long-term memory formation in migratory

Experiments (0)

Related Papers (0)

Debates (3)

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

The study identifies ADCY8 as associated with migratory distance differences and

The paper describes memory-based migration routes maintained across generations

Related Research