concept

NADH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NADH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

401Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NADH is a concept in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with AD, ADH, ALI. Connected to 218 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NADH
Key Genes/Proteins	ACETYL-COA, ACTB, Actin, AGING, AIF, AKT
Related Diseases	AD, ADH, Aging, ALI, Als

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NADH["NADH"]
    NADH -->|"regulates"| Ischemia["Ischemia"]
    NADH -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    NADH -->|"regulates"| Tumor["Tumor"]
    NADH -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NADH -->|"regulates"| Cancer["Cancer"]
    NADH -->|"activates"| Aging["Aging"]
    NADH -.protects against.-> Neuroinflammation["Neuroinflammation"]
    NADH -.protects against.-> Traumatic_Brain_Injury["Traumatic Brain Injury"]
    NADH -.protects against.-> Inflammation["Inflammation"]
    NADH -.protects against.-> Alzheimer["Alzheimer"]
    EEF2["EEF2"] -->|"binds"| NADH
    METHYLENE_BLUE["METHYLENE_BLUE"] -->|"interacts"| NADH
    MTOR["MTOR"] -->|"regulates"| NADH
    MYC["MYC"] -->|"regulates"| NADH
    EGFR["EGFR"] -->|"regulates"| NADH
    MTORC1["MTORC1"] -->|"regulates"| NADH
    RPS6["RPS6"] -->|"regulates"| NADH
    CTSD["CTSD"] -->|"regulates"| NADH
    ATG["ATG"] -->|"regulates"| NADH
    NAD["NAD"] -->|"regulates"| NADH

Outgoing (240)

Target	Relation	Type	Str
Als	activates	disease	0.85
NAD+ metabolism	participates_in	pathway	0.85
SIRT1	activates	gene	0.75
Cancer	associated_with	disease	0.75
Oxidative Stress	activates	pathway	0.70
MITOCHONDRIA	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Mitochondrial Function	activates	pathway	0.70
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	protects_against	disease	0.65
Huntington	associated_with	disease	0.65
Sepsis	activates	disease	0.65
Senescence	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Infection	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	activates	disease	0.65
Tumor	regulates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Anxiety	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	regulates	disease	0.65
Diabetes	activates	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Stroke	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Aging	expressed_in	disease	0.65
Fatty Liver	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
neurons	expressed_in	cell_type	0.65
Obesity	activates	disease	0.65
ALS	expressed_in	disease	0.65
Traumatic Brain Injury	protects_against	disease	0.65
Ischemia	regulates	disease	0.65
Lung Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ischemia	protects_against	disease	0.65
Stroke	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	protects_against	disease	0.65

Incoming (161)

Source	Relation	Type	Str
Methylene Blue	interacts_with	drug	0.90
IDH2	associated_with	entity	0.90
IDH1	associated_with	entity	0.90
EEF2	binds	gene	0.80
NAD	inhibits	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
CANCER	associated_with	gene	0.70
NAD	causes	gene	0.65
ISCHEMIA	regulates	disease	0.65
ATP	regulates	gene	0.65
NAD	biomarker_for	gene	0.65
METHYLENE_BLUE	interacts_with	drug	0.64
ATG	activates	gene	0.60
ATP	activates	gene	0.60
CAT	activates	gene	0.60
CPT1A	activates	gene	0.60
MTOR	activates	gene	0.60
rapamycin	targets	drug	0.60
GENES	activates	gene	0.60
PPAR	activates	gene	0.60
SIRT1	activates	gene	0.60
SREBF1	regulates	gene	0.60
ALS	interacts_with	gene	0.60
NAD	activates	gene	0.60
HIF	activates	gene	0.60
LC3B	associated_with	gene	0.60
AND	regulates	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
ALS	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AND	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
PPARA	regulates	gene	0.60
MAP1LC3C	associated_with	gene	0.60
CPT1A	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
ROS	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
NDUFV2	associated_with	gene	0.60
CD38	associated_with	gene	0.60
DNA	associated_with	gene	0.60
NAD	phosphorylates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
MTDNA	activates	gene	0.60
AMPK	associated_with	gene	0.60
AGING	associated_with	gene	0.60
AND	phosphorylates	gene	0.60
NAMPT	associated_with	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning NADH in their description or question text

No additional research found

NADH

Understanding Entity Pages

Summary

Wiki Pages (11)

NDUFS8 — NADH:Ubiquinone Oxidoreductase Core Subunit S8

NDUFAF2 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2

NDUFAF4 — NADH Dehydrogenase Complex Assembly Factor 4

NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5

NDUFS3 Gene - NADH:Ubiquinone Oxidoreductase Core Subunit S3

NDUFAF1 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1

NDUFAF8 Gene (NADH Dehydrogenase Complex Assembly Factor 8)

NDUFB1 — NADH:ubiquinone Oxidoreductase Subunit B1

MT-ND5 Protein (NADH Dehydrogenase 5)

MT-ND1 Gene - Mitochondrial NADH Dehydrogenase Subunit 1

NDUFA5 — NADH:ubiquinone Oxidoreductase Subunit A5