concept

INSULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

906Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INSULIN
Key Genes/Proteins	3r-tau, 4r-tau, ACTB, AKT, AKT2, ALZHEIMER
Related Diseases	aging, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Insulin Signaling in Parkinson's Disease

mechanism · 4072 words

→

Pathway Diagram

graph TD
    INSULIN["INSULIN"]
    INSULIN -->|"activates"| TUG["TUG"]
    INSULIN -->|"regulates"| blood_glucose_levels["blood glucose levels"]
    INSULIN -->|"regulates"| glucose_metabolism["glucose metabolism"]
    INSULIN -->|"activates"| neuron_outgrowth["neuron outgrowth"]
    INSULIN -->|"activates"| Insulin_receptor["Insulin receptor"]
    MTOR["MTOR"] -->|"activates"| INSULIN
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| INSULIN
    AKT["AKT"] -->|"activates"| INSULIN
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| INSULIN
    EGFR["EGFR"] -->|"activates"| INSULIN
    SQSTM1["SQSTM1"] -->|"activates"| INSULIN
    PI3K["PI3K"] -->|"mediates"| INSULIN
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| INSULIN

Outgoing (271)

Target	Relation	Type	Str
TUG	activates	protein	0.95
TUG	activates	entity	0.95
Food Intake	regulates	process	0.90
Glucose Uptake	regulates	process	0.90
glucose storage	associated_with	phenotype	0.90
blood glucose levels	regulates	phenotype	0.90
EAAT1	upregulates	protein	0.90
AKT	activates	protein	0.90
EAAT2	upregulates	protein	0.90
Oxidative Stress	treats	process	0.85
PI3K	activates	pathway	0.85
TUG	stimulates	protein	0.80
Alzheimer'S Disease	treats	disease	0.80
NEURODEGENERATION	treats	disease	0.80
IDE	upregulates	protein	0.80
NEURODEGENERATION	regulates	disease	0.80
neuron outgrowth	activates	process	0.70
Insulin receptor	activates	protein	0.70
glucose metabolism	regulates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
Obesity	associated_with	disease	0.60
Als	associated_with	disease	0.60
Fibrosis	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Epilepsy	activates	disease	0.60
Ferroptosis	contributes_to	disease	0.60
Dementia	expressed_in	disease	0.60
Neuroinflammation	causes	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Cancer	inhibits	disease	0.60
Diabetes	associated_with	disease	0.60
Diabetes	regulates	disease	0.60
Dementia	associated_with	disease	0.60
Cardiomyopathy	therapeutic_target	disease	0.60
Neuropathy	protects_against	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Ferroptosis	expressed_in	disease	0.60
Depression	activates	disease	0.60
Obesity	activates	disease	0.60
Cancer	associated_with	disease	0.60
Dementia	therapeutic_target	disease	0.60
Ferroptosis	regulates	disease	0.60
Neuropathy	associated_with	disease	0.60
Anxiety	activates	disease	0.60
Aging	regulates	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Obesity	regulates	disease	0.60
Fibrosis	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Neurodegeneration	associated_with	disease	0.60

Incoming (635)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
AMPK	associated_with	gene	0.90
BDNF	associated_with	gene	0.82
IL-6	associated_with	gene	0.82
TNF	associated_with	gene	0.82
MTOR	activates	gene	0.82
NF-KB	associated_with	protein	0.82
MTOR	associated_with	gene	0.82
AMPK	activates	gene	0.74
AKT	activates	gene	0.74
TAU	associated_with	protein	0.72
APOE	associated_with	gene	0.66
AMYLOID	inhibits	protein	0.66
PI3K	inhibits	gene	0.66
SOD1	associated_with	gene	0.66
AKT	associated_with	gene	0.66
IGF-1	regulates	gene	0.60
TAU	therapeutic_target	gene	0.60
ROS	associated_with	gene	0.60
GBA3	associated_with	gene	0.60
IL-6	activates	gene	0.60
RAS	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
NRF2	regulates	gene	0.60
AKT	activates	gene	0.60
CYP2C18	associated_with	gene	0.60
JUN	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
PD-L1	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
JUN	activates	gene	0.60
SLC22A2	associated_with	gene	0.60
HDAC	activates	gene	0.60
LOX	activates	gene	0.60
IGF2	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
FOXO1	regulates	gene	0.60
FGF	regulates	gene	0.60
MANF	regulates	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
IGF2R	associated_with	gene	0.60
AKT	regulates	gene	0.60
PI3K	regulates	gene	0.60
CCL4	activates	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Brain Insulin Resistance with Glucose Transporter Dysfunctio	0.596	neurodegeneration	Metabolic reprogramming in neurodegenera

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Comparative study of the glucolipid profile and GLUTs gene expression in respons [PMID:41232212]	["Wang Z", "Wang H", "Du P", "Zhang X",	Poultry science	2025
Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy an [PMID:41369048]	["Xu W", "Neal E", "Barlow N", "Thompson	Journal of neurochemistry	2025
Targeting glucose transporters in parkinson's disease: a novel metabolic approac [PMID:40879857]	["Singh G", "Ansari S", "Aran K"]	Metabolic brain disease	2025
Tirzepatide prevents neurodegeneration through multiple molecular pathways. [PMID:38287296]	Fontanella RA, Ghosh P, Pesapane A, Takt	Journal of translational medic	2024
A high fat diet potentiates neonatal iron overload-induced memory impairments in [PMID:38358514]	["do Nascimento F", "de Freitas B", "Dos	European journal of nutrition	2024
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582]	Yadav P, Antony-Babu S, Hayes E, Healy O	Microbiology resource announce	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INSULIN in their description or question text

No additional research found