concept

NOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NOX is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Cancer. Connected to 120 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NOX
Key Genes/Proteins	ACSL4, AKT, AMBRA1, AND, ANG, APOPTOSIS
Related Diseases	Als, ALS, Ataxia
Related Pathways	Akt, Apoptosis, apoptosis pathway
Linked Hypotheses	1 hypotheses

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NOX["NOX"]
    NOX -->|"activates"| Als["Als"]
    NOX -->|"activates"| Ms["Ms"]
    NOX -->|"activates"| Cancer["Cancer"]
    NOX -->|"activates"| Cardiac["Cardiac"]
    NOX -->|"activates"| Inflammation["Inflammation"]
    NOX -->|"activates"| ALS["ALS"]
    NOX -->|"produces"| ROS["ROS"]
    NOX -->|"activates"| POR["POR"]
    NOX -->|"regulates"| Ferroptosis["Ferroptosis"]
    LPCAT3["LPCAT3"] -->|"activates"| NOX
    ACSL4["ACSL4"] -->|"activates"| NOX
    G6PD["G6PD"] -->|"activates"| NOX
    SMAD3["SMAD3"] -->|"regulates"| NOX
    CDH1["CDH1"] -->|"activates"| NOX
    LC3B["LC3B"] -->|"activates"| NOX
    NOX4["NOX4"] -->|"activates"| NOX
    P62["P62"] -->|"activates"| NOX

Outgoing (114)

Target	Relation	Type	Str
Als	activates	disease	0.75
Autophagy	activates	pathway	0.70
ROS	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Immune Response	activates	pathway	0.70
Obesity	activates	disease	0.65
Infection	activates	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Cardiac	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Tumor	inhibits	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Autoimmune	activates	disease	0.65
Ataxia	associated_with	disease	0.65
ROS	produces	phenotype	0.64
DNA	associated_with	gene	0.60
Dna Damage Response	activates	pathway	0.60
Ras	activates	protein	0.60
P53	activates	gene	0.60
PI3K	activates	gene	0.60
PUMA	activates	gene	0.60
ROS	inhibits	gene	0.60
TLR	activates	gene	0.60
TRAF6	activates	gene	0.60
VEGF	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
ferroptosis	participates_in	pathway	0.60
ROS	phosphorylates	gene	0.60
TAAR1	activates	gene	0.60
DNA	inhibits	gene	0.60
Apoptosis	activates	pathway	0.60
Dna Repair	inhibits	pathway	0.60
HO-1	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60

Incoming (86)

Source	Relation	Type	Str
rapamycin	targets	drug	0.60
MYD88	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
AKT	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
LPCAT3	activates	gene	0.60
ACSL4	activates	gene	0.60
G6PD	activates	gene	0.60
SMAD3	regulates	gene	0.60
CDH1	activates	gene	0.60
ACSL4	regulates	gene	0.60
LPCAT3	regulates	gene	0.60
PI3K	associated_with	gene	0.60
LC3B	activates	gene	0.60
NOX4	activates	gene	0.60
P62	activates	gene	0.60
ATF6	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ROS	regulates	gene	0.60
POR	activates	gene	0.60
BAX	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
PUMA	associated_with	gene	0.60
P53	associated_with	gene	0.60
NUPR1	associated_with	gene	0.60
CREB	activates	gene	0.60
GAL	protects_against	gene	0.60
GSH	protects_against	gene	0.60
ATP	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NLRP3	activates	gene	0.60
ROS	associated_with	gene	0.60
NF-KB	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
AMBRA1	activates	gene	0.60
BAK1	activates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
BNIP3L	activates	gene	0.60
CASP1	activates	gene	0.60
CAT	activates	gene	0.60
CNP	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
GSH	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial NOX2 establishes an inflammatory ROS propagation	0.680	neurodegeneration	What mechanisms drive the self-amplifyin

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOX in their description or question text

No additional research found

NOX

Understanding Entity Pages

Summary

Wiki Pages (9)

NOX2 Gene

NOXA Gene (PMAIP1)

NOXA Protein

NOX4 Gene

NOX5 Gene

NOX1 Gene

NOXA1 Protein

NOX2/CYBB (NADPH Oxidase 2)

NOXO1 Protein