gene 1,454 words KG: NOXA
Contents

NOXA Gene (PMAIP1)

🧬 Gene Info
Gene SymbolNOXA
Full NamePMA-Induced mRNA 1
Chromosome18q21.32.
Functionencodes a pro-apoptotic BH3-only protein of the BCL-2 family that plays a critical role in regulating mitochondrial apoptosis.
Molecular Weight6.5 kDa
Amino Acids103 aa
Pathwayspathway: **BH3-Only Protein Function**
UniProt IDQ9Y2X9
NCBI Gene ID5366
Ensembl IDENSG00000141682
OMIM604958
GeneCardsNOXA
Human Protein AtlasNOXA
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, ATF4, BAX, BCL-2, BCL2, CDK4
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Glycosaminoglycan Template Disruption Approach
Score: 0.60

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (12)

Apoptosis in Neurodegeneration
entity · KG edge: activates
ATF4 Gene
gene · KG edge: activates
BAX Gene
gene · KG edge: inhibits
BCL2 Gene
gene · KG edge: activates
CDK4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

NOXA inhibits BAX
NOXA activates PITX3
NOXA activates BCL2
NOXA activates MDM2
NOXA activates CDK4
NOXA activates ATF4
NOXA activates CHOP
BAX activates NOXA
PINK1 therapeutic_target NOXA
NOXA activates PUMA

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