Contents

NOX2/CYBB (NADPH Oxidase 2)

🔬 Protein Info

Gene Symbol	NOX2
Function	Direct microbial killing: Superoxide and derivatives
Primary Expression	hippocampus
Molecular Weight	65 kDa
Amino Acids	570 aa
Exons	23
Pathways	Oxidative Stress, oxidative stress response, Endocytosis, Immune Response, Mtor
GeneCards	NOX2
Human Protein Atlas	NOX2
N-terminal transmembrane domain	Six membrane-spanning helices
Heme-binding sites	Two bis-histidine-coordinated hemes
Associated Diseases	Alzheimer, Parkinson, Traumatic Brain Injury
Known Drugs/Compounds	levodopa
Interactions	AKT, ALZHEIMER, AND, APOPTOSIS, ASTROCYTE, ASTROCYTES
KG Connections	180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

TNF activates NOX2

ATM activates NOX2

CLEC7A regulates NOX2

PTEN activates NOX2

PI3K activates NOX2

CX3CR1 interacts_with NOX2

NOX2 activates AKT

BAX expressed_in NOX2

NOX2 expressed_in SOD2

NOX2 expressed_in NRF2