gene

MYD88

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYD88: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

734Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Myeloid Differentiation Primary Response 88 - Central adaptor in TLR/IL-1R signaling and neuroinflammation in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	MYD88
Aliases	Myeloid Differentiation Primary Response 88
Protein Family	MyD88 adaptor proteins
Protein Type	Adaptor Protein
Function	MyD88 is an adaptor protein essential for signaling from most Toll-like receptors (TLRs) and IL-1R family members.
Molecular Weight	33 kDa
Pathways	NF-κB, MAPK pathway, MAPK
UniProt ID	[Q99836](https://www.uniprot.org/uniprot/Q99836)
GeneCards	MYD88
Human Protein Atlas	MYD88
Associated Diseases	Encephalitis, Inflammation, Ischemia, Lymphoma, Ms, Multiple Sclerosis
Interactions	ACOD1, AKT, AKT1, Albumin, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	726 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MYD88 Gene

gene · 893 words

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Pathway Diagram

flowchart TD
    MYD88["MYD88
MyD88 Adaptor Protein"]
    TLR4["TLR4
Toll-like Receptor 4"]
    InnateImmunity["Innate Immunity
Pathway"]
    Inflammation["Inflammation
Process"]
    Neuroinflammation["Neuroinflammation
CNS Inflammation"]
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    Parkinson["Parkinson's Disease
Neurodegeneration"]
    MS["Multiple Sclerosis
Autoimmune Disease"]
    Ischemia["Ischemia
Reduced Blood Flow"]
    TherapeuticTarget["Therapeutic
Intervention"]
    ProtectiveMechanism["Protective
Mechanisms"]
    PathologicalOutcome["Pathological
Outcomes"]

    MYD88 -->|"activates"| TLR4
    MYD88 -->|"inhibits"| InnateImmunity
    MYD88 -->|"activates"| Inflammation
    MYD88 -->|"protects against"| Neuroinflammation
    MYD88 -->|"activates"| Neuroinflammation
    TLR4 -->|"promotes"| Inflammation
    Inflammation -->|"leads to"| Neuroinflammation
    Neuroinflammation -->|"contributes to"| ALS
    Neuroinflammation -->|"contributes to"| Parkinson
    Neuroinflammation -->|"contributes to"| MS
    MYD88 -->|"inhibits"| Ischemia
    MYD88 -->|"therapeutic target"| TherapeuticTarget
    TherapeuticTarget -->|"targets"| ALS
    TherapeuticTarget -->|"targets"| MS
    TherapeuticTarget -->|"targets"| Neuroinflammation
    MYD88 -->|"dual role"| ProtectiveMechanism
    MYD88 -->|"dual role"| PathologicalOutcome

    style MYD88 fill:#006494
    style TLR4 fill:#4a1a6b
    style InnateImmunity fill:#4a1a6b
    style TherapeuticTarget fill:#1b5e20
    style ProtectiveMechanism fill:#1b5e20
    style Inflammation fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style ALS fill:#5d4400
    style Parkinson fill:#5d4400
    style MS fill:#5d4400
    style Ischemia fill:#ef5350
    style PathologicalOutcome fill:#ef5350

Outgoing (468)

Target	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Nf-Κb	activates	pathway	1.00
Nf-Κb	inhibits	pathway	1.00
inflammatory cytokines	regulates	phenotype	0.90
inflammatory cytokines	activates	protein	0.90
NF-κB	upstream_of	protein	0.90
NF-κB	activates	pathway	0.88
Neutrophil Extracellular Trap Formation	involved_in	process	0.88
Innate Immune Response	involved_in	process	0.85
MAPK	activates	pathway	0.80
Immune Response	regulates	pathway	0.80
Nf-Κb	regulates	pathway	0.80
Oxidative Stress	activates	pathway	0.80
INFLAMMATION	activates	gene	0.80
Toll-Like Receptor	regulates	pathway	0.80
CYTOKINES	activates	gene	0.80
Parkinson	activates	disease	0.75
Tumor	activates	disease	0.75
Neuroinflammation	activates	disease	0.75
Cancer	activates	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Inflammation	regulates	disease	0.75
Inflammation	inhibits	disease	0.75
Infection	activates	disease	0.75
Als	expressed_in	disease	0.75
Als	inhibits	disease	0.75
NF-ΚB	inhibits	gene	0.70
Toll-Like Receptor	inhibits	pathway	0.70
MICROGLIA	activates	gene	0.70
MMP9	activates	protein	0.70
NF-ΚB	activates	gene	0.70
TLR7	activates	gene	0.70
Apoptosis	activates	pathway	0.70
NEUROINFLAMMATION	activates	gene	0.70
Immune Response	activates	pathway	0.70
TLR9	activates	gene	0.70
CYTOKINES	inhibits	gene	0.70
Asthma	regulates	disease	0.65
Atherosclerosis	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Lung Cancer	activates	disease	0.65
Pneumonia	regulates	disease	0.65
TLR4	phosphorylates	gene	0.65
Neuroinflammation	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Heart Failure	expressed_in	disease	0.65
Sepsis	activates	disease	0.65

Incoming (266)

Source	Relation	Type	Str
NF-ΚB	activates	gene	0.90
TLR4	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
TLR4	activates	gene	0.80
TIRAP	interacts_with	protein	0.80
NF-ΚB	inhibits	gene	0.80
NF-ΚB	regulates	gene	0.80
TLR4	inhibits	gene	0.80
TNF	activates	gene	0.80
IL-6	activates	gene	0.80
DRD2	associated_with	gene	0.70
APOPTOSIS	activates	gene	0.70
TNF-Α	activates	gene	0.70
NLRP3	regulates	gene	0.70
TLR4	interacts_with	protein	0.70
INFLAMMATION	regulates	gene	0.70
TH	inhibits	gene	0.70
INFLAMMATION	inhibits	gene	0.70
PARKINSON	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
TH	interacts_with	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
CYTOKINES	activates	gene	0.70
TLR	regulates	gene	0.70
DEPRESSION	targets	disease	0.65
IL10	regulates	gene	0.65
TLR4	causes	gene	0.65
AUTOPHAGY	associated_with	gene	0.60
TLR	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
HO-1	associated_with	gene	0.60
BCL-2	associated_with	gene	0.60
GENES	inhibits	gene	0.60
TSLP	regulates	gene	0.60
NF-KB	expressed_in	gene	0.60
EPO	regulates	gene	0.60
PARKINSON'S DISEASE	treats	gene	0.60
PARKINSON	treats	gene	0.60
INFLAMMATION	treats	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HIF	regulates	gene	0.60
TNF-Α	regulates	gene	0.60
KRAS	activates	gene	0.60
P53	activates	gene	0.60
CANCER	activates	gene	0.60
ACOD1	activates	gene	0.60
AND	expressed_in	gene	0.60
AQP3	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Related Research

Hypotheses and analyses mentioning MYD88 in their description or question text

No additional research found