concept

TLR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

746Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

5Experiments

0Debates

Summary

TLR is a concept in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 477 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	TLR
Key Genes/Proteins	ACE, ACOD1, ACSL4, ACTB, AGING, AIM2
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt
Linked Hypotheses	8 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TLR["TLR"]
    TLR -->|"activates"| innate_immunity["innate immunity"]
    TLR -->|"activates"| ACOD1["ACOD1"]
    TLR -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    TLR -->|"target for"| Cardiovascular["Cardiovascular"]
    TLR -->|"target for"| Inflammation["Inflammation"]
    TLR -->|"target for"| Als["Als"]
    TLR -->|"target for"| Cancer["Cancer"]
    TLR -->|"target for"| Ms["Ms"]
    TLR -->|"target for"| Tumor["Tumor"]
    TLR -->|"target for"| Autoimmune["Autoimmune"]
    MTOR["MTOR"] -->|"regulates"| TLR
    JAK["JAK"] -->|"interacts"| TLR
    PI3K["PI3K"] -->|"expressed in"| TLR
    BAX["BAX"] -->|"activates"| TLR
    NLRC5["NLRC5"] -->|"interacts"| TLR
    NLRP12["NLRP12"] -->|"interacts"| TLR
    CYTOKINES["CYTOKINES"] -->|"interacts"| TLR

Outgoing (515)

Target	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Toll-Like Receptor	activates	pathway	1.00
Inflammation	regulates	disease	0.95
innate immunity	activates	pathway	0.90
Toll-Like Receptor	inhibits	pathway	0.90
Toll-Like Receptor	associated_with	pathway	0.90
Immune Response	activates	pathway	0.90
Cancer	activates	disease	0.85
Als	regulates	disease	0.85
Cancer	regulates	disease	0.85
ACOD1	activates	gene	0.80
JAK-STAT signaling	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neuroinflammation	regulates	disease	0.80
Immune Response	regulates	pathway	0.80
Oxidative Stress	activates	pathway	0.80
Nf-Κb	inhibits	pathway	0.80
Nf-Κb	activates	pathway	0.80
Tumor	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Ischemia	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Obesity	activates	disease	0.75
Autoimmune	regulates	disease	0.75
Inflammation	associated_with	disease	0.75
Cardiac	activates	disease	0.75
Neurodegeneration	regulates	disease	0.75
Infection	activates	disease	0.75
Cardiovascular	regulates	disease	0.75
Tumor	activates	disease	0.75
STING	activates	gene	0.70
GENES	activates	gene	0.70
Innate Immunity	activates	pathway	0.70
UBIQUITIN	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Inflammasome	activates	pathway	0.70
TNF-Α	inhibits	gene	0.70
Nf-Κb	regulates	pathway	0.70
INFLAMMATION	associated_with	gene	0.70
CANCER	activates	gene	0.70
TNF-Α	activates	gene	0.70
MTOR	activates	gene	0.70
NLRP3	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
IFN	activates	gene	0.70
NF-kB signaling	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Autophagy	associated_with	pathway	0.70

Incoming (231)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
INFLAMMATION	regulates	gene	0.90
TLR4	activates	gene	0.90
NFKB	interacts_with	pathway	0.80
NF-ΚB	inhibits	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
AUTOPHAGY	associated_with	gene	0.70
IL-6	activates	gene	0.70
NF-ΚB	regulates	gene	0.70
TNF	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
CYTOKINES	regulates	gene	0.70
NF-ΚB	activates	gene	0.70
TNF	inhibits	gene	0.70
CYTOKINES	activates	gene	0.70
JNK	activates	gene	0.70
rapamycin	targets	drug	0.70
NLRP3	regulates	gene	0.70
PI3K	inhibits	gene	0.70
ROS	regulates	gene	0.70
MTOR	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
PUMA	associated_with	gene	0.60
NOX	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AKT	inhibits	gene	0.60
TNF	regulates	gene	0.60
NF-ΚB	associated_with	gene	0.60
IL-6	regulates	gene	0.60
ROS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
TLR3	activates	gene	0.60
IRF3	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PRO-INFLAMMATORY GENES	inhibits	gene	0.60
AND	activates	gene	0.60
TLR7	causes	gene	0.60
AND	causes	gene	0.60
IFN	causes	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
CHOP	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
P53	associated_with	gene	0.60
NUPR1	associated_with	gene	0.60
NLR	interacts_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	7.200	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam	0.789	neurodegeneration	What are the mechanisms by which gut mic
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Resveratrol protection against renal I/R injury in diabetic rats	validation	diabetic nephropathy	0.900	streptozotocin-induced diabeti	proposed	N/A
TLR expression analysis in Parkinson's disease patients	clinical	Parkinson's disease	0.850	human patients	proposed	N/A
Resveratrol effects on HK-2 cells under hypoxia/reoxygenation	exploratory	diabetic nephropathy	0.850	HK-2 cells cultured in high gl	proposed	N/A
TLR4 Activation Assay with NETs and Anti-CarP Antibodies	exploratory	rheumatoid arthritis	0.850	HEK293 TLR4 reporter cells	proposed	N/A
TLR expression in α-synuclein overexpressing mice	validation	Parkinson's disease	0.800	mice overexpressing human α-sy	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086]	Li Z, Tan D, Lin J, Zhang T, Liu B et al	J Adv Res	2026	0
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111]	Cao F, Zhang P, Zheng Z, Wang P, Wang Y	Neurol Res	2026	0
CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399]	Zhang Y, Wang J, Song Y, Chai J, Li L et	Biochem Pharmacol	2026	0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026	0
2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238]	Chen J, Liang S, Liu D, Yang S, Yan Q et	J Agric Food Chem	2026	0
Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324]	Yan H, Chia D, Ernst S, Demuytere J, Cos	Expert Opin Drug Deliv	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627]	Nakabo S, Hanata N, Patino-Martinez E, H	Arthritis Rheumatol	2026	0
In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545]	Zheng N, Xu Y	PLoS Negl Trop Dis	2026	0
Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597]	Ma B, Lyu W, Rizk J, Han X, Kjær M et al	Sci Immunol	2026	0
Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877]	Waghmare A, Rahangdale S, Khare K, Taksa	Molecular and cellular neurosc	2026	0
Nanopiezoelectric 3D-Bioprinted Neural Organoid Models Epileptic Neuron-Microgli [PMID:41877549]	Chu J, Hu K, Lee WF, Xu SJ, Sun Z, Xu Y,	Nano letters	2026	0
The Neuroameliorative Effects of Enzymatically Modified Isoquercitrin and Sodium [PMID:41880086]	Hassouna I, Hassanein OH, El-Elaimy IA,	Neurochemical research	2026	0
Role of Pentacyclic Triterpenes in the Management of Neurological Disorders: An [PMID:41870813]	Upadhayay S	Molecular neurobiology	2026	0
Hyperglycaemia-induced metabolic stress and epigenetic imprinting in the inflamm [PMID:41730508]	Razi FB, Ashraf H, Singhal S, Qamar Z, M	Diabetes research and clinical	2026	0
Colonic Barrier Dysfunction and Inflammation Induced by Nano-/Micro-Plastics Fib [PMID:41923296]	Li Y, Bao S, Huang P, Wang J, Li H, Liu	Journal of applied toxicology	2026	0
Artemisinin attenuates 3-nitropropionic acid-induced neurodegeneration via HMGB1 [PMID:41865324]	Mustafa AM, Mudhafar M, Elgindy AM, Esma	Archives of pharmacal research	2026	0
Curcumin and Glycyrrhiza glabra Synergistically Attenuate Alzheimer's Pathology [PMID:41920384]	Liu S, Yan J, Dong J	Neurochemical research	2026	0
The spleen-brain axis in Alzheimer's disease and related dementias: Integrating [PMID:41778859]	Yan J, Zhang J, Ye X, Wang H, Li H, Li W	Alzheimer's & dementia : the j	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TLR in their description or question text

No additional research found

TLR

Understanding Entity Pages

Summary

Wiki Pages (21)

TLR Signaling in Parkinson's Disease

TLR5-Mediated Microglial Neuroinflammation Hypothesis

TLR Signaling Pathway in Neurodegeneration

TLR5 Gene

TLR8 Gene

TLR10 Gene

TLR7/8/9 Antagonists for Neurodegeneration

TLR4 Antagonists for Neurodegeneration

TLR6 Gene

CpG1018 TLR9 Agonist Phase 1 Trial (NCT05606341)

TLR9 — Toll-Like Receptor 9

TLR2 — Toll-Like Receptor 2

TLR7/8/9 Antagonists for Neurodegeneration

Toll-Like Receptor 4 (TLR4)

TLR1 Protein

TLR9 Protein — Toll-Like Receptor 9

TLR1 Gene

TLR3 Protein — Toll-Like Receptor 3

TLR2 Protein — Toll-Like Receptor 2

TLR7 Protein

TLR5 Protein