gene 980 words KG: NOX1
Contents

NOX1 Gene

🧬 Gene Info
Gene SymbolNOX1
Full NameNADPH Oxidase 1
ChromosomeXq22
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncertain neuronal populations and glial cells within the brain
Molecular Weight65 kDa
Amino Acids564 aa
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID[Q9Y5S5](https://www.uniprot.org/uniprot/Q9Y5S5)
Ensembl IDENSG00000156508
OMIM300225
GeneCardsNOX1
Human Protein AtlasNOX1
6 transmembrane domainsPosition heme groups for electron transfer
Dehydrogenase domainContains FAD and NADPH binding sites
Associated Diseasesdisease, ferroptosis, neurodegeneration, Parkinson, Parkinson's Disease
Known Drugs/Compoundsrapamycin
InteractionsACTB, ATG5, BECN1, CAT, CDKN1A, CTSD
KG Connections103 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
BAG1 Gene
gene · KG edge: regulates
CHMP3 — Charged Multivesicular Body Protein 3
gene · KG edge: regulates

Knowledge Graph (12 edges)

EGF activates NOX1
NOX1 interacts_with EGFR
NBN regulates NOX1
SGK3 regulates NOX1
TNF regulates NOX1
SLC24A2 regulates NOX1
DNAJC2 regulates NOX1
CHMP3 regulates NOX1
PDE4C regulates NOX1
BAG1 regulates NOX1

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