gene

NOX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NOX2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, expressed in. Associated with Als, Ataxia, Atherosclerosis. Connected to 76 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NOX2
Full Name	NADPH Oxidase 2
Function	Direct microbial killing: Superoxide and derivatives
Primary Expression	hippocampus
Molecular Weight	65 kDa
Amino Acids	570 aa
Exons	23
Pathways	Oxidative Stress, oxidative stress response, Endocytosis, Immune Response, Mtor
GeneCards	NOX2
Human Protein Atlas	NOX2
Electron donor	NADPH provides the electrons
Associated Diseases	Alzheimer, Parkinson, Traumatic Brain Injury
Known Drugs/Compounds	levodopa
Interactions	AKT, ALZHEIMER, AND, APOPTOSIS, ASTROCYTE, ASTROCYTES
KG Connections	180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NOX2 Gene

gene · 1989 words

→

NOX2/CYBB (NADPH Oxidase 2)

protein · 785 words

→

Pathway Diagram

graph TD
    NOX2["NOX2"]
    Oxidative_Stress(["Oxidative Stress"])
    NOX2 -->|"contributes to"| Oxidative_Stress
    Als{"Als"}
    NOX2 -->|"activates"| Als
    Ataxia{"Ataxia"}
    NOX2 -->|"activates"| Ataxia
    Atherosclerosis{"Atherosclerosis"}
    NOX2 -->|"regulates"| Atherosclerosis
    NOX2 -->|"activates"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    NOX2 -->|"implicated in"| neurodegeneration
    CLEC7A["CLEC7A"]
    CLEC7A -->|"regulates"| NOX2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| NOX2
    ATM["ATM"]
    ATM -->|"activates"| NOX2
    TNF["TNF"]
    TNF -->|"activates"| NOX2
    style NOX2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
Oxidative Stress	activates	pathway	0.80
Inflammation	inhibits	disease	0.75
oxidative stress response	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
Parkinson	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
Als	activates	disease	0.65
Sepsis	inhibits	disease	0.65
Ataxia	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Tumor	activates	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	activates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	interacts_with	disease	0.65
BRAIN INJURY	implicated_in	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TNF-Α	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
AND	activates	gene	0.60
NEURON	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Complement	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	inhibits	cell_type	0.60
PARKINSON	associated_with	gene	0.60
Il-1	inhibits	protein	0.60
pyroptosis	participates_in	pathway	0.60

Incoming (70)

Source	Relation	Type	Str
CLEC7A	regulates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
ROS	inhibits	gene	0.70
ROS	associated_with	gene	0.60
PTEN	activates	gene	0.60
PI3K	activates	gene	0.60
CX3CR1	interacts_with	gene	0.60
BAX	expressed_in	gene	0.60
STAT3	activates	gene	0.60
TNF	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
C3	activates	gene	0.60
C3	inhibits	gene	0.60
NADPH	protects_against	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
LRRK2	inhibits	gene	0.60
NLRP3	interacts_with	gene	0.60
ROS	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
ROS	therapeutic_target	gene	0.60
CR3	regulates	gene	0.60
levodopa	targets	drug	0.60
NEURON	inhibits	gene	0.60
CR3	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ATM	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMPK	expressed_in	gene	0.60
ERK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
GFAP	biomarker_for	gene	0.60
IBA1	biomarker_for	gene	0.60
NOS2	biomarker_for	gene	0.60
CXCR4	activates	gene	0.60
NLRP3	activates	gene	0.60
LRRK2	activates	gene	0.60
ENDOSOMES	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial NOX2 establishes an inflammatory ROS propagation	0.680	neurodegeneration	What mechanisms drive the self-amplifyin

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOX2 in their description or question text

No additional research found