concept

NOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NOX is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Cancer. Connected to 120 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NOX
Key Genes/Proteins	ACSL4, AKT, AMBRA1, AND, ANG, APOPTOSIS
Related Diseases	Als, ALS, Ataxia
Related Pathways	Akt, Apoptosis, apoptosis pathway
Linked Hypotheses	1 hypotheses

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NOX["NOX"]
    NOX -->|"activates"| Als["Als"]
    NOX -->|"activates"| Ms["Ms"]
    NOX -->|"activates"| Cancer["Cancer"]
    NOX -->|"activates"| Cardiac["Cardiac"]
    NOX -->|"activates"| Inflammation["Inflammation"]
    NOX -->|"activates"| ALS["ALS"]
    NOX -->|"produces"| ROS["ROS"]
    NOX -->|"activates"| POR["POR"]
    NOX -->|"regulates"| Ferroptosis["Ferroptosis"]
    LPCAT3["LPCAT3"] -->|"activates"| NOX
    ACSL4["ACSL4"] -->|"activates"| NOX
    G6PD["G6PD"] -->|"activates"| NOX
    SMAD3["SMAD3"] -->|"regulates"| NOX
    CDH1["CDH1"] -->|"activates"| NOX
    LC3B["LC3B"] -->|"activates"| NOX
    NOX4["NOX4"] -->|"activates"| NOX
    P62["P62"] -->|"activates"| NOX

Outgoing (114)

Target	Relation	Type	Str
Als	activates	disease	0.75
ROS	activates	gene	0.70
Immune Response	activates	pathway	0.70
Autophagy	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Autoimmune	activates	disease	0.65
ALS	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Cardiac	activates	disease	0.65
Infection	activates	disease	0.65
Obesity	activates	disease	0.65
Tumor	inhibits	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Als	regulates	disease	0.65
ROS	produces	phenotype	0.64
RAGE	activates	gene	0.60
MYD88	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
TLR	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
CREB	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ROS	regulates	gene	0.60
OPA1	activates	gene	0.60
PARL	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
SLC7A11	activates	gene	0.60
SQSTM1	activates	gene	0.60
TXN	activates	gene	0.60
VCP	activates	gene	0.60
Wnt signaling	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ROS	phosphorylates	gene	0.60
POR	regulates	gene	0.60
Er Stress	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60

Incoming (86)

Source	Relation	Type	Str
LPCAT3	activates	gene	0.60
ACSL4	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
FIS1	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
SIGMAR1	associated_with	gene	0.60
CREB	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
TLR	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
HO-1	associated_with	gene	0.60
BCL-2	associated_with	gene	0.60
ROS	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NOX2	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
CASP1	activates	gene	0.60
CAT	activates	gene	0.60
CNP	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
GSH	activates	gene	0.60
GSK3B	activates	gene	0.60
GSR	activates	gene	0.60
HIF1A	activates	gene	0.60
HUWE1	activates	gene	0.60
IL1B	activates	gene	0.60
LC3	activates	gene	0.60
MUL1	activates	gene	0.60
NADPH	activates	gene	0.60
NIX	activates	gene	0.60
NLR	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ATM	regulates	gene	0.60
AND	regulates	gene	0.60
CREB	activates	gene	0.60
rapamycin	targets	drug	0.60
ROS	activates	gene	0.60
SIRT1	activates	gene	0.60
MTORC1	activates	gene	0.60
MICRORNAS	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
GAL	protects_against	gene	0.60
GSH	protects_against	gene	0.60
PI3K	associated_with	gene	0.60
MYD88	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial NOX2 establishes an inflammatory ROS propagation	0.680	neurodegeneration	What mechanisms drive the self-amplifyin

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOX in their description or question text

No additional research found

NOX

Understanding Entity Pages

Summary

Wiki Pages (9)

NOX2 Gene

NOXA Gene (PMAIP1)

NOXA Protein

NOX4 Gene

NOX5 Gene

NOX1 Gene

NOXA1 Protein

NOX2/CYBB (NADPH Oxidase 2)

NOXO1 Protein