biological_process

BLOOD-BRAIN BARRIER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2370Connections

6Hypotheses

1Analyses

50Outgoing

50Incoming

9Experiments

1Debates

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🧬 Biological Process Info

Name	BLOOD-BRAIN BARRIER
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CarThera

company · 662 words

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Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"causes"| PARP1["PARP1"]
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"regulates"| CLDN5["CLDN5"]
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"causes"| ENDOTHELIAL["ENDOTHELIAL"]
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"causes"| STROKE["STROKE"]
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"impairs"| MICROGLIA["MICROGLIA"]
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"impairs"| ENDOTHELIAL_1["ENDOTHELIAL"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    MICROGLIA_2["MICROGLIA"] -->|"associated"| BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated"| BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    style BLOOD_BRAIN_BARRIER fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (231)

Target	Relation	Type	Str
Biologics Delivery	inhibits	mechanism	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Brain Homeostasis	associated_with	process	0.95
Cerebral Endothelial Cells	component_of	cell_type	0.95
Neuronal Function	involved_in	phenotype	0.90
Cognitive Decline	causes	phenotype	0.90
Neuroinflammation	associated_with	process	0.90
Neurodegeneration	involved_in	disease	0.90
Brain Hemorrhage	risk_factor_for	phenotype	0.90
Brain Arteriovenous Malformations	biomarker_for	disease	0.85
AMYLOID-BETA	regulates	protein	0.85
Amyloid Beta	transports	protein	0.85
Drug Permeability	involved_in	phenotype	0.85
Neurotoxic Compounds Clearance	mediates	process	0.80
Neurovascular Coupling	associated_with	process	0.80
neurodegeneration	mediates	process	0.80
Compound Penetration	inhibits	phenotype	0.78
Amyloid β-targeted monoclonal antibodies	modulates	drug	0.75
Cerebral edema	causes	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
TKI accumulation	inhibits	process	0.70
hippocampus	regulates	brain_region	0.70
Autophagy	interacts_with	pathway	0.55
Ubiquitin-Proteasome	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Pyroptosis	interacts_with	pathway	0.55
T Cell	therapeutic_target	cell_type	0.50
Microglia	protects_against	cell_type	0.50
Astrocyte	protects_against	cell_type	0.50
Neuron	protects_against	cell_type	0.50
Microglia	regulates	cell_type	0.50
Endothelial	causes	cell_type	0.50
Astrocyte	inhibits	cell_type	0.50
T Cell	inhibits	cell_type	0.50
Macrophage	inhibits	cell_type	0.50
T Cell	expressed_in	cell_type	0.50
Microglia	contributes_to	cell_type	0.50
Monocyte	contributes_to	cell_type	0.50
Neutrophil	contributes_to	cell_type	0.50
Neural Progenitor	activates	cell_type	0.50
Fibroblast	interacts_with	cell_type	0.50
Pericyte	interacts_with	cell_type	0.50
Pericyte	protects_against	cell_type	0.50
Pericyte	therapeutic_target	cell_type	0.50
Stem Cell	interacts_with	cell_type	0.50
Neuron	interacts_with	cell_type	0.50
Pericyte	expressed_in	cell_type	0.50

Incoming (2139)

Source	Relation	Type	Str
INFLAMMATION	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
MICROGLIA	therapeutic_target	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
MICROGLIA	activates	gene	1.00
Inflammation	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
NEURODEGENERATION	activates	gene	1.00
Neuroinflammation	associated_with	disease	1.00
APOPTOSIS	therapeutic_target	gene	1.00
Inflammation	associated_with	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
Als	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Parkinson	therapeutic_target	disease	1.00
Alzheimer	associated_with	disease	1.00
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
Stroke	therapeutic_target	disease	1.00
AMYLOID	activates	gene	1.00
PARKINSON'S DISEASE	therapeutic_target	gene	1.00
Als	implicated_in	disease	1.00
ALZHEIMER'S DISEASE	implicated_in	gene	1.00
Alzheimer	implicated_in	disease	1.00
Neurodegeneration	activates	disease	1.00
AMYLOID	therapeutic_target	gene	1.00
Inflammation	inhibits	disease	1.00
ALZHEIMER	implicated_in	gene	1.00
INFLAMMATION	inhibits	gene	1.00
Als	inhibits	disease	1.00
Als	activates	disease	1.00
ALZHEIMER	activates	gene	1.00
Aging	therapeutic_target	disease	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
ALZHEIMER	associated_with	gene	1.00
CYTOKINES	activates	gene	1.00
Alzheimer	activates	disease	1.00
ALZHEIMER	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
STROKE	therapeutic_target	gene	1.00

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.846	Alzheimer's disease	Circuit-level neural dynamics in neurode
Blood-Brain Barrier SPM Shuttle System	0.533	neurodegeneration	Neuroinflammation resolution mechanisms
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.513	neuroinflammation	Why do TAM receptors protect against neu
TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blo	0.499	neuroscience	Circuit-level neural dynamics in neurode
Blood-Brain Barrier Disruption Enabling Peripheral Inflammat	0.430	neurodegeneration	How does APOE4 mechanistically increase

Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri	0.406	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (1)

Scientific analyses that reference this entity

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - ALOX15 overexpression in healthy astrocytes should be protectiv	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Progranulin Replacement Therapy for FTD — Vector Development and Valid	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies [PMID:40447280]	Russell CD, Goeldner-Thompson S, Smith E	J Infect Dis	2025	1
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766]	Huang Q, Chan KY, Wu J, Botticello-Romer	Science	2024	1
Targeting the transferrin receptor to transport antisense oligonucleotides acros [PMID:39141703]	Barker SJ, Thayer MB, Kim C, Tatarakis D	Sci Transl Med	2024	1
Blood-brain barrier transport using a high affinity, brain-selective VNAR antibo [PMID:33241587]	Stocki P, Szary J, Rasmussen CLM, Demydc	FASEB J	2021	1
Transferrin receptor 1 in cancer: a new sight for cancer therapy. [PMID:30034931]	Shen Y, Li X, Dong D, Zhang B, Xue Y, Sh	American journal of cancer res	2018	1
Cadmium exposure is associated with impaired ovarian function: Potential role of [PMID:41548307]	["Li J", "Wang Y", "Huang Y", "Li N", "Z	Journal of hazardous materials	2026	0
A humanized transferrin receptor 1-transferrin model supports functional iron ho [PMID:41338456]	Yesiltepe M, Metkar S, Yin T, Chakrabort	The Journal of biological chem	2026	0
Early hypoxia-induced secretome remodeling reveals adaptive mechanisms and bioma [PMID:41699623]	Wu Q, Jiang Y, Peng L, Dang Y, You C, Li	Molecular brain	2026	0
MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis i [PMID:41832955]	Han D, Han L, Kang L, Liu J, Zhang N, Tu	Cell reports	2026	0
Ferrostatin-1 alleviates experimental cerebral malaria by regulating immune cell [PMID:41422632]	Yao S, Zhou X, Liao T, Yao C, Sun M, Gou	International journal for para	2025	0
Dietary Iron Deficiency in Adult Mice Increases Brain Uptake of High-Affinity, A [PMID:41299828]	Kostrikov S, Johnsen KB, Burkhart A, Hel	Journal of neurochemistry	2025	0
A covalent peptide-based lysosome-targeting protein degradation platform for can [PMID:39910101]	Xiao Y, He Z, Li W, Chen D, Niu X, Yang	Nature communications	2025	0
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis. [PMID:38743190]	["Hu K", "Jiang P", "Hu J", "Song B", "H	Journal of bioenergetics and b	2024	0
Ferroptosis promotes valproate-induced liver steatosis in vitro and in vivo. [PMID:39147356]	["Yan X", "Ma L", "Chen X", "Ren J", "Zh	Food and chemical toxicology :	2024	0
TfR-conjugated nanoparticles achieve 50-fold increase in brain delivery vs free [PMID:synthetic_13]	Unknown	ACS Nano	2023	0
Specialized pro-resolving mediators reduce brain inflammation and amyloid pathol [PMID:synthetic_9]	Unknown	Nature Med	2023	0
TfR saturation limits uptake of targeting ligands at physiological transferrin c [PMID:synthetic_15]	Unknown	Mol Pharm	2022	0
Resolvin D1 promotes microglial phagocytosis and suppresses inflammatory cytokin [PMID:synthetic_11]	Unknown	J Neuroinflammation	2021	0
High-dose SPM analogs cause off-target immunosuppression in sepsis models [PMID:synthetic_14]	Unknown	Crit Care Med	2021	0
ALOX15 polymorphisms associated with Alzheimer's disease risk and age of onset [PMID:synthetic_12]	Unknown	Ann Neurol	2020	0

Debates (1)

Multi-agent debates referencing this entity

The debate assumed static 5-hydroxymethylcytosine patterns in aging neurons are

closed · Rounds: 4 · Score: 0.95 · 2026-04-16