gene 1,989 words KG: NOX2
Contents

NOX2 Gene

🧬 Gene Info
Gene SymbolNOX2
Full NameNADPH Oxidase 2
FunctionDirect microbial killing: Superoxide and derivatives
Primary Expressionhippocampus
Molecular Weight65 kDa
Amino Acids570 aa
Exons23
PathwaysOxidative Stress, oxidative stress response, Endocytosis, Immune Response, Mtor
GeneCardsNOX2
Human Protein AtlasNOX2
Electron donorNADPH provides the electrons
SubstrateMolecular oxygen
Prosthetic groupsFAD and two heme groups (b-type cytochrome)
Associated DiseasesAlzheimer, Parkinson, Traumatic Brain Injury
Known Drugs/Compoundslevodopa
InteractionsAKT, ALZHEIMER, AND, APOPTOSIS, ASTROCYTE, ASTROCYTES
KG Connections180 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.92
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Astrocytes
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target
Astrocytes
entity · KG edge: inhibits

Knowledge Graph (12 edges)

TNF activates NOX2
ATM activates NOX2
CLEC7A regulates NOX2
PTEN activates NOX2
PI3K activates NOX2
CX3CR1 interacts_with NOX2
NOX2 activates AKT
BAX expressed_in NOX2
NOX2 expressed_in SOD2
NOX2 expressed_in NRF2

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