Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ANG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ANG is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Cancer, Cardiac. Connected to 149 entities in the SciDEX knowledge graph.
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| Gene Symbol | ANG |
| Full Name | Angiogenin |
| Aliases | Gene profile: ANG |
| Chromosome | 14q11.2 |
| Protein Type | Protein |
| Function | is a multifunctional protein that plays critical roles in both physiological and pathological processes within the nervous system. |
| Molecular Weight | 14 kDa |
| Amino Acids | 147 aa |
| Exons | 2 |
| Pathways | NF-κB |
| UniProt ID | Search UniProt |
| GeneCards | ANG |
| Human Protein Atlas | ANG |
| Associated Diseases | Cardiac, Heart Failure, Hypertension, Inflammation, Neuroinflammation |
| Interactions | Actin, AGING, AKT, AND, ANXA2, APOE |
| KG Connections | 266 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ANG["ANG"]
Als{"Als"}
ANG -->|"inhibits"| Als
Cardiovascular{"Cardiovascular"}
ANG -->|"activates"| Cardiovascular
Inflammation{"Inflammation"}
ANG -->|"activates"| Inflammation
Fibrosis{"Fibrosis"}
ANG -->|"activates"| Fibrosis
Cardiac{"Cardiac"}
ANG -->|"activates"| Cardiac
Ms{"Ms"}
ANG -->|"activates"| Ms
ANG -->|"activates"| Als
Tumor{"Tumor"}
ANG -->|"activates"| Tumor
KCNK2["KCNK2"]
ANG -->|"activates"| KCNK2
ANG -->|"inhibits"| KCNK2
NRP1["NRP1"]
ANG -->|"activates"| NRP1
APOE["APOE"]
ANG -->|"associated with"| APOE
PKC["PKC"]
PKC -->|"inhibits"| ANG
TRPA1["TRPA1"]
TRPA1 -->|"regulates"| ANG
MIRNAS["MIRNAS"]
MIRNAS -->|"regulates"| ANG
CAT["CAT"]
CAT -->|"activates"| ANG
ANXA2["ANXA2"]
ANXA2 -->|"activates"| ANG
TLR4["TLR4"]
TLR4 -->|"activates"| ANG
BCL2["BCL2"]
BCL2 -->|"activates"| ANG
style ANG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.85 |
| Cardiac | activates | disease | 0.85 |
| Inflammation | activates | disease | 0.75 |
| Cardiovascular | activates | disease | 0.75 |
| Heart Failure | associated_with | disease | 0.75 |
| Mtor | activates | pathway | 0.70 |
| TNF | activates | gene | 0.70 |
| Apoptosis | activates | pathway | 0.70 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Inflammation | biomarker_for | disease | 0.65 |
| Obesity | activates | disease | 0.65 |
| Cardiovascular | treats | disease | 0.65 |
| Cardiac | implicated_in | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| Fibrosis | inhibits | disease | 0.65 |
| Sickle Cell | biomarker_for | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Sepsis | activates | disease | 0.65 |
| Cardiac | causes | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| SPG11 | associated_with | gene | 0.60 |
| TAF15 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| VAPB | associated_with | gene | 0.60 |
| VCP | associated_with | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| RUNX1 | activates | gene | 0.60 |
| Tgf-Β | activates | pathway | 0.60 |
| ROS | treats | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ROS | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| NOX | activates | gene | 0.60 |
| NEUROTOXICITY | associated_with | gene | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.60 |
| CYTOKINES | therapeutic_target | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| NF-ΚB | therapeutic_target | gene | 0.60 |
| TNF-Α | therapeutic_target | gene | 0.60 |
| ROS | treats | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 0.60 |
| FLAVONOIDS | treats | gene | 0.60 |
| POSTN | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ASTROCYTE | expressed_in | gene | 0.60 |
| AQUAPORIN-4 | expressed_in | gene | 0.60 |
| PIEZO | activates | gene | 0.60 |
| PKC | inhibits | gene | 0.60 |
| TRPA1 | regulates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| GATA2 | activates | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| ACE | implicated_in | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| EGF | expressed_in | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| MIRNAS | regulates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| ANXA2 | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| GSN | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| YY1 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| NCF1 | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| NF-KB | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| IL8 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Longitudinal dietary change analysis and ADRD risk over 10 years | clinical | Alzheimer's disease and relate | 0.930 | 0.00 | human patients | proposed | N/A |
| Leukocyte gene expression analysis in COVID-19 patients | exploratory | COVID-19 | 0.900 | 0.00 | human leukocytes from COVID-19 | proposed | N/A |
| Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] | Xiao F, Tan X, He A, Zhou Y, Xu K et al. | Autophagy | 2026 | 0 |
| Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013] | ["S\u00e1ez J", "Ocaranza F", "Prieto-Vi | Journal of neurochemistry | 2025 | 0 |
| Genetic variants in ganglioside synthesis enzymes associate with Alzheimer's dis [PMID:synthetic_29] | Unknown | Nat Genet | 2024 | 0 |
| CSF ganglioside ratios predict Alzheimer's disease progression and correlate wit [PMID:synthetic_27] | Unknown | JAMA Neurol | 2023 | 0 |
| Overlap in synaptic neurological condition susceptibility pathways and the neura [PMID:37807670] | ["Frederiksen S", "Wicki-Stordeur L", "S | Channels (Austin, Tex.) | 2023 | 0 |
| Small-molecule modulation of ganglioside synthesis normalizes brain lipid compos [PMID:synthetic_26] | Unknown | Nat Neurosci | 2023 | 0 |
| Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect [PMID:35168327] | ["Wang D", "Zhang T", "Maduni\u0107 K", | Journal of proteome research | 2022 | 0 |
| Brain ganglioside composition is dysregulated in Alzheimer's disease with GM1 de [PMID:synthetic_24] | Unknown | Ann Neurol | 2022 | 0 |
| GM1 enhances BDNF-TrkB signaling and neuroprotection via lipid raft organization [PMID:synthetic_28] | Unknown | Mol Psychiatry | 2022 | 0 |
| Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] | Persson RM, Tellnes K, Hoven H, Haaverst | Anaesthesia reports | 2022 | 0 |
| Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] | Fujiya Y, Harada T, Sugawara Y, Akeda Y, | Scientific reports | 2021 | 0 |
| Ganglioside composition varies widely across brain regions and cell types [PMID:synthetic_32] | Unknown | J Lipid Res | 2021 | 0 |
| High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] | Helmuth B, Leichter JJ, Rotjan RD, Casti | Scientific data | 2020 | 0 |
| Exogenous GM1 administration improves cognition and reduces pathology in APP/PS1 [PMID:synthetic_25] | Unknown | Neurobiol Aging | 2020 | 0 |
| Exogenous GM1 shows limited CNS bioavailability in clinical trials for Parkinson [PMID:synthetic_30] | Unknown | Mov Disord | 2019 | 0 |
| Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures. [PMID:30862176] | ["Scemes E", "Vel\u00ed\u0161ek L", "Vel | ASN neuro | 2019 | 0 |
| Ganglioside synthesis inhibitors cause peripheral neuropathy in Gaucher disease [PMID:synthetic_31] | Unknown | Ann Neurol | 2018 | 0 |
| Expression and function of pannexins in the inner ear and hearing. [PMID:27229462] | ["Zhao H"] | BMC cell biology | 2016 | 0 |
| Pannexins in ischemia-induced neurodegeneration. [PMID:22147915] | ["Bargiotas P", "Krenz A", "Hormuzdi S", | Proceedings of the National Ac | 2011 | 0 |
| Dynamism in gene expression across multiple studies. [PMID:19920211] | ["Morgan A", "Dudley J", "Deshpande T", | Physiological genomics | 2010 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ANG in their description or question text
Score: 0.517 · neuroinflammation · 2026-04-21
## Mechanistic Overview Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Downregulation via NRF2 starts from the
Score: 0.489 · neuropharmacology · 2026-04-25
The scaffold alters receptor signaling efficacy without strong orthosteric affinity by modifying redox-sensitive lipid n
Score: 0.470 · neurodegeneration · 2026-04-25
This hypothesis claims HBOT at 1.5-2.0 ATA produces sub-lethal oxidative stress that paradoxically stabilizes HIF-1α des
Score: 0.465 · lipidomics · 2026-04-25
GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization Seeds
Score: 0.436 · neurodegeneration · 2026-04-02
Selective opening of pannexin-1 hemichannels creates controlled conduits for small mitochondria and mitochondrial compon
Score: 0.420 · molecular biology · 2026-04-24
A more conjectural model is that APOE4-driven lipid remodeling changes ER membrane organization so that SCAP perceives c