protein

ANG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

266Connections
11Hypotheses
0Analyses
50Outgoing
50Incoming
3Experiments
0Debates

Summary

ANG is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Cancer, Cardiac. Connected to 149 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolANG
Full NameAngiogenin
AliasesGene profile: ANG
Chromosome14q11.2
Protein TypeProtein
Functionis a multifunctional protein that plays critical roles in both physiological and pathological processes within the nervous system.
Molecular Weight14 kDa
Amino Acids147 aa
Exons2
PathwaysNF-κB
UniProt IDSearch UniProt
GeneCardsANG
Human Protein AtlasANG
Associated DiseasesCardiac, Heart Failure, Hypertension, Inflammation, Neuroinflammation
InteractionsActin, AGING, AKT, AND, ANXA2, APOE
KG Connections266 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: ANG — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

ANG — Angiogenin

gene · 2561 words

ANG Protein (Angiogenin)

protein · 2618 words

ANG Protein

protein · 2518 words

ANG Protein (Angiogenin)

protein · 909 words

BANG — BAG3 (Bcl-2-Associated Athanogene 3)

gene · 893 words

Pathway Diagram

graph TD
    ANG["ANG"]
    Als{"Als"}
    ANG -->|"inhibits"| Als
    Cardiovascular{"Cardiovascular"}
    ANG -->|"activates"| Cardiovascular
    Inflammation{"Inflammation"}
    ANG -->|"activates"| Inflammation
    Fibrosis{"Fibrosis"}
    ANG -->|"activates"| Fibrosis
    Cardiac{"Cardiac"}
    ANG -->|"activates"| Cardiac
    Ms{"Ms"}
    ANG -->|"activates"| Ms
    ANG -->|"activates"| Als
    Tumor{"Tumor"}
    ANG -->|"activates"| Tumor
    KCNK2["KCNK2"]
    ANG -->|"activates"| KCNK2
    ANG -->|"inhibits"| KCNK2
    NRP1["NRP1"]
    ANG -->|"activates"| NRP1
    APOE["APOE"]
    ANG -->|"associated with"| APOE
    PKC["PKC"]
    PKC -->|"inhibits"| ANG
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| ANG
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| ANG
    CAT["CAT"]
    CAT -->|"activates"| ANG
    ANXA2["ANXA2"]
    ANXA2 -->|"activates"| ANG
    TLR4["TLR4"]
    TLR4 -->|"activates"| ANG
    BCL2["BCL2"]
    BCL2 -->|"activates"| ANG
    style ANG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (182)

TargetRelationTypeStr
Alsactivatesdisease0.85
Cardiacactivatesdisease0.85
Inflammationactivatesdisease0.75
Cardiovascularactivatesdisease0.75
Heart Failureassociated_withdisease0.75

Incoming (84)

SourceRelationTypeStr
ROSactivatesgene0.60
MTORC1activatesgene0.60
MICRORNASactivatesgene0.60
NOXactivatesgene0.60
NEUROTOXICITYassociated_withgene0.60

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Ganglioside Rebalancing Therapy 0.690 neurodegeneration Lipid raft composition changes in synapt
Microglial priming is primarily epigenetic, with metabolic c 0.609 neuroinflammation Do microglia actually switch between gly
Ganglioside-rich extracellular vesicles preserve alpha-synuc 0.582 neurodegeneration Which specific CSF molecular components
LYTL and JIP4-dependent lysosomal remodeling may show mutant 0.580 neurodegeneration Do pathogenic LRRK2 mutations amplify vo
C1Q-Angiogenic Axis Promoting Plaque Neovascularization 0.530 neuroinflammation What are the specific molecular mechanis
Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Dow 0.517 neuroinflammation What causes IBA1 low/negative microglia
Parthenolide changes ADORA2A coupling efficiency through mem 0.489 neuropharmacology How does parthenolide specifically modul
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α 0.470 neurodegeneration What are the optimal oxygen pressure, du
GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ 0.465 lipidomics Lipid metabolism dysregulation in Alzhei
Gap Junction Hemichannel Modulation for Controlled Mitochond 0.436 neurodegeneration Mitochondrial transfer between neurons a
APOE4 alters the accessible-cholesterol threshold sensed by 0.420 molecular biology Does APOE4's reduced lipid-binding direc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years clinical Alzheimer's disease and relate 0.930 0.00 human patients proposed N/A
Leukocyte gene expression analysis in COVID-19 patients exploratory COVID-19 0.900 0.00 human leukocytes from COVID-19 proposed N/A
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease clinical Parkinson's Disease 0.400 0.50 human proposed $7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] Xiao F, Tan X, He A, Zhou Y, Xu K et al. Autophagy 2026 0
Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013] ["S\u00e1ez J", "Ocaranza F", "Prieto-Vi Journal of neurochemistry 2025 0
Genetic variants in ganglioside synthesis enzymes associate with Alzheimer's dis [PMID:synthetic_29] Unknown Nat Genet 2024 0
CSF ganglioside ratios predict Alzheimer's disease progression and correlate wit [PMID:synthetic_27] Unknown JAMA Neurol 2023 0
Overlap in synaptic neurological condition susceptibility pathways and the neura [PMID:37807670] ["Frederiksen S", "Wicki-Stordeur L", "S Channels (Austin, Tex.) 2023 0
Small-molecule modulation of ganglioside synthesis normalizes brain lipid compos [PMID:synthetic_26] Unknown Nat Neurosci 2023 0
Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect [PMID:35168327] ["Wang D", "Zhang T", "Maduni\u0107 K", Journal of proteome research 2022 0
Brain ganglioside composition is dysregulated in Alzheimer's disease with GM1 de [PMID:synthetic_24] Unknown Ann Neurol 2022 0
GM1 enhances BDNF-TrkB signaling and neuroprotection via lipid raft organization [PMID:synthetic_28] Unknown Mol Psychiatry 2022 0
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] Persson RM, Tellnes K, Hoven H, Haaverst Anaesthesia reports 2022 0
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] Fujiya Y, Harada T, Sugawara Y, Akeda Y, Scientific reports 2021 0
Ganglioside composition varies widely across brain regions and cell types [PMID:synthetic_32] Unknown J Lipid Res 2021 0
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] Helmuth B, Leichter JJ, Rotjan RD, Casti Scientific data 2020 0
Exogenous GM1 administration improves cognition and reduces pathology in APP/PS1 [PMID:synthetic_25] Unknown Neurobiol Aging 2020 0
Exogenous GM1 shows limited CNS bioavailability in clinical trials for Parkinson [PMID:synthetic_30] Unknown Mov Disord 2019 0
Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures. [PMID:30862176] ["Scemes E", "Vel\u00ed\u0161ek L", "Vel ASN neuro 2019 0
Ganglioside synthesis inhibitors cause peripheral neuropathy in Gaucher disease [PMID:synthetic_31] Unknown Ann Neurol 2018 0
Expression and function of pannexins in the inner ear and hearing. [PMID:27229462] ["Zhao H"] BMC cell biology 2016 0
Pannexins in ischemia-induced neurodegeneration. [PMID:22147915] ["Bargiotas P", "Krenz A", "Hormuzdi S", Proceedings of the National Ac 2011 0
Dynamism in gene expression across multiple studies. [PMID:19920211] ["Morgan A", "Dudley J", "Deshpande T", Physiological genomics 2010 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANG in their description or question text

Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Downregulation via NRF2

Score: 0.517 · neuroinflammation · 2026-04-21

## Mechanistic Overview Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Downregulation via NRF2 starts from the

Parthenolide changes ADORA2A coupling efficiency through membrane microdomain re

Score: 0.489 · neuropharmacology · 2026-04-25

The scaffold alters receptor signaling efficacy without strong orthosteric affinity by modifying redox-sensitive lipid n

Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α to enhance VEGF-med

Score: 0.470 · neurodegeneration · 2026-04-25

This hypothesis claims HBOT at 1.5-2.0 ATA produces sub-lethal oxidative stress that paradoxically stabilizes HIF-1α des

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization See

Score: 0.465 · lipidomics · 2026-04-25

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization Seeds

Gap Junction Hemichannel Modulation for Controlled Mitochondrial Exchange

Score: 0.436 · neurodegeneration · 2026-04-02

Selective opening of pannexin-1 hemichannels creates controlled conduits for small mitochondria and mitochondrial compon

APOE4 alters the accessible-cholesterol threshold sensed by SCAP through ER memb

Score: 0.420 · molecular biology · 2026-04-24

A more conjectural model is that APOE4-driven lipid remodeling changes ER membrane organization so that SCAP perceives c