gene

SMAD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

375Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SMAD3 is a transcription factor and key mediator of TGF-β signaling, implicated in Alzheimer's Disease, Parkinson's Disease, and Loeys-Dietz syndrome.

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🧬 Gene Info

Gene Symbol	SMAD3
Full Name	SMAD Family Member 3
Chromosome	15q22.33
Protein Type	Transcription Factor
Function	encodes a transcription factor that serves as a central mediator of TGF-β (Transforming Growth Factor Beta) signaling.
Primary Expression	Brain (cortex, hippocampus, substantia nigra), Lung, Heart, Blood vessels
Molecular Weight	48 kDa
Pathways	TGF-β, TGF-β signaling
UniProt ID	P84022
NCBI Gene ID	4088
Ensembl ID	ENSG00000166949
OMIM	603109
GeneCards	SMAD3
Human Protein Atlas	SMAD3
Linker domain	Contains regulatory phosphorylation sites and interaction motifs for various kinases
Associated Diseases	Aging, Als, Alzheimer, Crohn'S Disease, Diabetes
Known Drugs/Compounds	lycopene
Interactions	ABCG2, ACTB, adamts4, ADAMTS4, AGING, AKT
KG Connections	374 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAD3 — AlphaFold P84022 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMAD3 — SMAD Family Member 3

gene · 2938 words

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Pathway Diagram

graph TD
    SMAD3["SMAD3"]
    SMAD3 -->|"regulates"| mitophagy["mitophagy"]
    SMAD3 -->|"activates"| Aging["Aging"]
    SMAD3 -->|"activates"| Ms["Ms"]
    SMAD3 -->|"activates"| Inflammation["Inflammation"]
    SMAD3 -->|"expressed in"| Fibrosis["Fibrosis"]
    SMAD3 -->|"target for"| Stroke["Stroke"]
    SMAD3 -->|"activates"| Diabetes["Diabetes"]
    lycopene["lycopene"] -->|"inhibits"| SMAD3
    BMAL1["BMAL1"] -->|"activates"| SMAD3
    ADAMTS4["ADAMTS4"] -->|"activates"| SMAD3
    SQSTM1["SQSTM1"] -->|"expressed in"| SMAD3
    MAP1LC3["MAP1LC3"] -->|"expressed in"| SMAD3
    P62["P62"] -->|"expressed in"| SMAD3
    PINK1["PINK1"] -->|"expressed in"| SMAD3
    BNIP3["BNIP3"] -->|"activates"| SMAD3
    GENES["GENES"] -->|"activates"| SMAD3

Outgoing (259)

Target	Relation	Type	Str
Pericytes	expressed_in	cell_type	0.95
mitophagy	regulates	pathway	0.90
Crohn's Disease	risk_factor_for	disease	0.85
Crohn'S Disease	associated_with	disease	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Inflammation	activates	disease	0.85
Treg differentiation	promotes	process	0.80
Tissue Fibrosis	associated_with	disease	0.80
Renal Fibrosis	involved_in	disease	0.80
TGF-beta signaling	participates_in	pathway	0.80
Tgf-Β	activates	pathway	0.80
Cancer	inhibits	disease	0.75
Tumor	regulates	disease	0.75
Tumor	inhibits	disease	0.75
Als	regulates	disease	0.75
Cancer	expressed_in	disease	0.75
Als	expressed_in	disease	0.75
oxidative stress response	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
TGF	inhibits	gene	0.70
CANCER	interacts_with	disease	0.70
Hepatic Fibrosis	activates	disease	0.70
Tgf-Β	inhibits	pathway	0.70
Mitophagy	activates	pathway	0.70
CANCER	inhibits	gene	0.70
INFLAMMATION	activates	gene	0.70
Aging	activates	disease	0.65
Cardiomyopathy	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Sepsis	activates	disease	0.65
Aging	associated_with	disease	0.65
Senescence	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Diabetes	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Fibrosis	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Ms	activates	disease	0.65

Incoming (116)

Source	Relation	Type	Str
lycopene	inhibits	drug	0.80
SMAD2	regulates	gene	0.70
MITOPHAGY	activates	gene	0.70
STAT3	activates	gene	0.70
AGING	causes	phenotype	0.65
ADAMTS4	activates	gene	0.60
SQSTM1	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
BNIP3	activates	gene	0.60
TGFB1	activates	gene	0.60
FUNDC1	activates	gene	0.60
BACE1	activates	gene	0.60
NLRP3	activates	gene	0.60
SIRT1	therapeutic_target	gene	0.60
PP2A	regulates	gene	0.60
BNIP3L	activates	gene	0.60
SMAD4	regulates	gene	0.60
HK2	biomarker_for	gene	0.60
PLK1	inhibits	gene	0.60
TERT	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
TGFBR2	expressed_in	gene	0.60
SMAD7	regulates	gene	0.60
PRKN	expressed_in	gene	0.60
LC3	expressed_in	gene	0.60
FOXO3	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
VEGFA	interacts_with	gene	0.60
SMAD2	associated_with	gene	0.60
ACTB	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
IL10	associated_with	gene	0.60
DNMT3A	associated_with	gene	0.60
BMAL1	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
P53	inhibits	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
AND	activates	gene	0.60
P21	activates	gene	0.60
ITGB8	activates	gene	0.60
STAT3	inhibits	gene	0.60
APC	activates	gene	0.60
JAK2	activates	gene	0.60
GENES	associated_with	gene	0.60
MAP1LC3	expressed_in	gene	0.60
GLUT4	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity