protein

CCND1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCND1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

401Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for CCND1 Protein (Cyclin D1)

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🔬 Protein Info

Gene Symbol	CCND1
Aliases	Cyclin D1
Primary Expression	Hippocampus
Molecular Weight	34 kDa
Amino Acids	100 aa
Pathways	Autophagy, Wnt, Mtor, Nf-Κb, Pi3K/Akt
GeneCards	CCND1
Human Protein Atlas	CCND1
Associated Diseases	ALS, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	AKT, AMPK, AND, APC, APOPTOSIS, ATG
KG Connections	401 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

CCND1 Protein (Cyclin D1)

protein · 554 words

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Pathway Diagram

graph TD
    CCND1(["CCND1"])
    chromothripsis["chromothripsis"]
    MYC["MYC"]
    Tumor["Tumor"]
    Cancer["Cancer"]
    ALS["ALS"]
    Carcinoma["Carcinoma"]
    Als["Als"]
    Alzheimer["Alzheimer"]
    Diabetes["Diabetes"]
    Fibrosis["Fibrosis"]
    Glioblastoma["Glioblastoma"]
    ATG["ATG"]
    TCF4["TCF4"]
    TSPAN1["TSPAN1"]
    AXIN["AXIN"]
    chromothripsis -->|"upstream_of"| CCND1
    MYC -->|"coexpressed_wit"| CCND1
    CCND1 -->|"activates"| Tumor
    CCND1 -.-|"associated"| Cancer
    CCND1 -->|"activates"| ALS
    CCND1 -.-|"associated"| Carcinoma
    CCND1 -->|"expressed in"| ALS
    CCND1 -->|"expressed in"| Carcinoma
    CCND1 -->|"activates"| Als
    CCND1 -->|"expressed in"| Als
    CCND1 -->|"regulates"| Alzheimer
    CCND1 -.->|"inhibits"| Diabetes
    CCND1 -.->|"inhibits"| Fibrosis
    CCND1 -->|"activates"| Cancer
    CCND1 -->|"activates"| Glioblastoma
    CCND1 -.-|"associated"| MYC
    CCND1 -.-|"associated"| ATG
    CCND1 -.-|"associated"| TCF4
    CCND1 -.-|"associated"| TSPAN1
    CCND1 -.-|"associated"| AXIN
    style CCND1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (264)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Alzheimer	regulates	disease	0.65
Diabetes	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Glioblastoma	activates	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Actin	associated_with	protein	0.60
Egfr	expressed_in	protein	0.60
Cytokine	expressed_in	protein	0.60
CYTOKINES	inhibits	gene	0.60
GNAL	inhibits	gene	0.60
IL8	inhibits	gene	0.60
VEGFA	targets	gene	0.60
AMPK	associated_with	gene	0.60
TERT	targets	gene	0.60
TNFRSF19	targets	gene	0.60
Rb	inhibits	protein	0.60
CDK4	interacts_with	gene	0.60
MDM2	interacts_with	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
CTLA4	targets	gene	0.60
DKK1	targets	gene	0.60
EOMES	targets	gene	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
JAG1	targets	gene	0.60
LEF1	targets	gene	0.60
MITF	targets	gene	0.60
MYC	targets	gene	0.60
NEUROD1	targets	gene	0.60
NOTCH2	targets	gene	0.60
NRCAM	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
SNAI1	targets	gene	0.60
RAB7A	associated_with	gene	0.60

Incoming (137)

Source	Relation	Type	Str
chromothripsis	upstream_of	process	0.80
MYC	coexpressed_with	gene	0.76
NPY1R	regulates	gene	0.60
DUSP1	regulates	gene	0.60
VPS37B	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
SESN1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MYH2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
AND	regulates	gene	0.60
NDRG2	regulates	gene	0.60
CALM2	regulates	gene	0.60
MTORC1	regulates	gene	0.60
PI3K	activates	gene	0.60
ADCY9	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
EGFR	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
AKT	activates	gene	0.60
EGFR MUTATIONS	expressed_in	gene	0.60
BCL2	activates	gene	0.60
CASP3	activates	gene	0.60
BAMBI	targets	gene	0.60
ATG	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
IL1B	activates	gene	0.60
BCL2L1	activates	gene	0.60
RNA	expressed_in	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
HUB GENES	regulates	gene	0.60
AXIN1	activates	gene	0.60
MIRNAS	activates	gene	0.60
RHEB	activates	gene	0.60
MIR-155	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HNF4A	activates	gene	0.60
AXIN2	targets	gene	0.60
MIR454	associated_with	gene	0.60
AMPK	activates	gene	0.60
APC	activates	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
BCL2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCND1 in their description or question text

No additional research found