protein

EGR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

421Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Early Growth Response protein 1 - zinc finger transcription factor regulating immediate-early gene programs in neurodegeneration

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🔬 Protein Info

Gene Symbol	EGR1
Full Name	Early Growth Response 1
Aliases	Early Growth Response protein 1
Chromosome	5q31
Protein Type	Transcription Factor
Function	EGR1 is an immediate-early transcription factor that regulates neuronal plasticity, learning, memory, and response to neural activity.
Molecular Weight	59.8 kDa
Pathways	MAPK
UniProt ID	P18146
NCBI Gene ID	1958
Ensembl ID	ENSG00000120738
OMIM	129500
GeneCards	EGR1
Human Protein Atlas	EGR1
Associated Diseases	AD, ALI, Als, Alzheimer, ARM
Known Drugs/Compounds	metformin
Interactions	AGING, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections	421 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EGR1 — AlphaFold P18146 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EGR1 Gene

gene · 704 words

→

EGR1 Protein

protein · 1108 words

→

Pathway Diagram

graph TD
    EGR1["EGR1"]
    EGR1 -->|"regulates"| FGF2["FGF2"]
    EGR1 -->|"participates in"| oxidative_stress["oxidative stress"]
    EGR1 -->|"participates in"| cardiac_hypertrophy["cardiac hypertrophy"]
    EGR1 -->|"target for"| Cancer["Cancer"]
    EGR1 -->|"target for"| Ms["Ms"]
    EGR1 -->|"target for"| Tumor["Tumor"]
    EGR1 -->|"activates"| Als["Als"]
    EGR1 -->|"activates"| Fibrosis["Fibrosis"]
    autophagy["autophagy"] -->|"activates"| EGR1
    MAPK_ERK["MAPK/ERK"] -->|"activates"| EGR1
    FGF2 -->|"activates"| EGR1
    TGFB1["TGFB1"] -->|"activates"| EGR1
    SOD1_downregulation["SOD1 downregulation"] -->|"activates"| EGR1
    IGF1R["IGF1R"] -->|"activates"| EGR1
    PTBP1["PTBP1"] -->|"activates"| EGR1
    TARDBP["TARDBP"] -->|"activates"| EGR1
    CALCOCO2["CALCOCO2"] -->|"activates"| EGR1
    PDGFRB["PDGFRB"] -->|"activates"| EGR1

Outgoing (269)

Target	Relation	Type	Str
FGF2	upregulates	gene	0.95
FGF2	regulates	protein	0.90
HNRNPA1	upregulates	gene	0.90
PRMT1	activates	gene	0.85
Proximal Tubule	expressed_in	cell_type	0.85
PRMT1	regulates	entity	0.85
cardiac hypertrophy	participates_in	phenotype	0.80
oxidative stress	participates_in	phenotype	0.80
Fibrosis	activates	disease	0.75
Autophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Als	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Gastric Cancer	implicated_in	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	inhibits	disease	0.65
ALS	activates	disease	0.65
Diabetes	activates	disease	0.65
Hypertension	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Als	activates	disease	0.65
neurons	expressed_in	cell_type	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
ALS	degrades	disease	0.65
Tumor	activates	disease	0.65
Retinopathy	activates	disease	0.65
neurotrophin signaling	participates_in	pathway	0.65
Atherosclerosis	inhibits	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Cardiovascular	activates	disease	0.65
ALS	regulates	disease	0.65
Als	degrades	disease	0.65
PDGF_BB	regulates	protein	0.64
Neuron	regulates	cell_type	0.60
Fibroblast	activates	cell_type	0.60

Incoming (152)

Source	Relation	Type	Str
Autophagy	activates	process	0.95
autophagy	activates	pathway	0.95
Autophagy Deficiency	downregulates	phenotype	0.90
FGF2	activates	protein	0.90
MAPK/ERK	activates	protein	0.90
Acute Kidney Injury	associated_with	disease	0.85
TGFB1	activates	protein	0.80
PRMT1	interacts_with	gene	0.80
SOD1 downregulation	activates	gene	0.70
IGF1R	activates	protein	0.64
AND	associated_with	gene	0.60
GENES	activates	gene	0.60
CANCER	associated_with	gene	0.60
AGING	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
BTG2	encodes	gene	0.60
CCND1	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
WT1	associated_with	gene	0.60
ERBB2	associated_with	gene	0.60
metformin	targets	drug	0.60
AUTOPHAGY	activates	gene	0.60
HNRNPA1	activates	gene	0.60
NDP52	activates	gene	0.60
HNRNPK	activates	gene	0.60
IGF1	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
GATA2	protects_against	gene	0.60
TNF	regulates	gene	0.60
GAPDH	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
AKT	interacts_with	entity	0.60
ATF3	protects_against	entity	0.60
CEBPA	protects_against	entity	0.60
PPARG	protects_against	gene	0.60
NFKB1	protects_against	gene	0.60
ESR1	regulates	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
PRMT1	encodes	gene	0.60
VEGF	activates	gene	0.60
MMP9	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EGR1 in their description or question text

No additional research found