gene

SOX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

546Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive page on SOX2 transcription factor in neural stem cells and neurodegeneration

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🧬 Gene Info

Gene Symbol	SOX2
Full Name	SRY-Box Transcription Factor 2
Chromosome	3q26.33
Protein Type	Transcription Factor
Function	The SOX2 protein forms homodimers or heterodimers with other SOX proteins to bind specific DNA sequences (AACAAT/G) and regulate gene expression.
Primary Expression	Neural stem cells, neural progenitors, specific mature neurons
Molecular Weight	34 kDa
Amino Acids	80 aa
Pathways	Alzheimer's Disease Pathogenesis, Autophagy, Cell Cycle, Circadian Rhythm, Epigenetic
UniProt ID	P35745
NCBI Gene ID	6657
Ensembl ID	ENSG00000104946
OMIM	184429
GeneCards	SOX2
Human Protein Atlas	SOX2
Associated Diseases	aging, ALS, Alzheimer's Disease, disease, Inflammation
Interactions	ACTB, ACTG1, AGING, AKT, ALDH1L1, ALZHEIMER
KG Connections	544 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SOX2 — AlphaFold P35745 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SOX2

gene · 2034 words

→

SOX2 Protein

protein · 1634 words

→

Pathway Diagram

graph TD
    SOX2["SOX2"]
    SOX2 -->|"interacts"| PARP1["PARP1"]
    SOX2 -->|"interacts"| PARP2["PARP2"]
    SOX2 -->|"interacts"| PRKDC["PRKDC"]
    SOX2 -->|"interacts"| XRCC1["XRCC1"]
    SOX2 -->|"interacts"| XRCC5["XRCC5"]
    SOX2 -->|"interacts"| XRCC6["XRCC6"]
    SOX2 -->|"interacts"| RPA1["RPA1"]
    SOX2 -->|"interacts"| LIG3["LIG3"]
    SOX2 -->|"interacts"| DDB1["DDB1"]
    SOX2 -->|"activates"| Cancer["Cancer"]
    LIFR["LIFR"] -->|"upregulates"| SOX2
    YAP["YAP"] -->|"activates"| SOX2
    POU5F1["POU5F1"] -->|"activates"| SOX2
    FGFR1["FGFR1"] -->|"target for"| SOX2
    KLF4["KLF4"] -->|"activates"| SOX2
    IL6["IL6"] -->|"activates"| SOX2
    ALDH1L1["ALDH1L1"] -->|"inhibits"| SOX2
    DLK2["DLK2"] -->|"inhibits"| SOX2
    EGF["EGF"] -->|"inhibits"| SOX2
    GFAP["GFAP"] -->|"inhibits"| SOX2

Outgoing (335)

Target	Relation	Type	Str
iPSC Reprogramming	involved_in	process	0.95
Tumor	inhibits	disease	0.95
Multipotency	associated_with	process	0.95
Cancer	inhibits	disease	0.95
Pluripotency	associated_with	process	0.95
Totipotency	regulates	process	0.95
Tumor	therapeutic_target	disease	0.95
Neural Stem Cells	regulates	cell_type	0.92
DAX1	interacts_with	gene	0.90
NANOG	interacts_with	gene	0.90
Embryonic Stem Cells	expressed_in	cell_type	0.90
OCT4	interacts_with	gene	0.90
Cell Differentiation	regulates	process	0.90
Pluripotency	activates	phenotype	0.90
KLF4	interacts_with	gene	0.90
Neurogenesis	associated_with	process	0.88
Cancer	therapeutic_target	disease	0.85
Transcription	regulates	process	0.85
Notch Signaling	involved_in	pathway	0.85
Cellular Senescence	associated_with	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.80
Alzheimer'S Disease	associated_with	disease	0.80
Alzheimer's Disease	associated_with	disease	0.80
Stem Cell	inhibits	pathway	0.80
Als	inhibits	disease	0.75
Als	therapeutic_target	disease	0.75
Aging	expressed_in	disease	0.75
Cancer	activates	disease	0.75
Skin Fibroblasts	expressed_in	cell_type	0.75
Stem Cell Aging	regulates	process	0.75
Alzheimer's Disease	associated_with	disease	0.75
Mtor	therapeutic_target	pathway	0.70
Metastasis	inhibits	pathway	0.70
MTOR	therapeutic_target	gene	0.70
Epigenetic	expressed_in	pathway	0.70
Astrocyte Heterogeneity	biomarker_for	phenotype	0.70
CANCER	inhibits	gene	0.70
ATG10	inhibits	gene	0.70
Wnt	regulates	pathway	0.70
Carcinoma	regulates	disease	0.65
Senescence	associated_with	disease	0.65
Breast Cancer	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Leukemia	therapeutic_target	disease	0.65

Incoming (211)

Source	Relation	Type	Str
miRNAs	regulates	biomarker	0.80
OCT4	regulates	gene	0.80
CANCER	therapeutic_target	gene	0.70
AKT	therapeutic_target	gene	0.70
AGING	expressed_in	gene	0.70
CANCER	inhibits	gene	0.70
Melatonin	upregulates	drug	0.70
Alzheimer's Disease	downregulates	disease	0.70
CD44	inhibits	gene	0.70
CANCER	activates	gene	0.70
KLF4	regulates	gene	0.70
YAP	activates	protein	0.64
GFAP	expressed_in	entity	0.60
NOTCH1	expressed_in	entity	0.60
NESTIN	activates	gene	0.60
EGF	activates	gene	0.60
TUBULIN	activates	gene	0.60
SOX10	expressed_in	gene	0.60
GDNF	activates	gene	0.60
FGF2	activates	gene	0.60
CHRNA7	expressed_in	gene	0.60
YAP1	activates	gene	0.60
DCX	activates	gene	0.60
GFAP	activates	gene	0.60
RB1	inhibits	gene	0.60
CANCER	biomarker_for	gene	0.60
NOTCH	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
GENES	activates	gene	0.60
AGING	biomarker_for	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AGING	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ROS	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
AMPK	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
HIPPO	regulates	gene	0.60
TLR	therapeutic_target	gene	0.60
YAP	regulates	gene	0.60
MTORC1	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
AKT	inhibits	gene	0.60
DLK2	expressed_in	entity	0.60
ALDH1L1	inhibits	gene	0.60
DLK2	inhibits	gene	0.60
EGF	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti	0.540	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SOX2 in their description or question text

No additional research found