gene

TXNIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TXNIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

258Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TXNIP is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with Als, Atherosclerosis, Diabetes. Connected to 65 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TXNIP
Chromosome	1q21.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	virtually all tissues, with particularly high expression in brain (especially hippocampus, hypothalamus, and cortex), he
Molecular Weight	46 kDa
Amino Acids	397 aa
Exons	9
Pathways	Amyloid, Er Stress, Inflammasome, Nf-Κb
NCBI Gene ID	10628
GeneCards	TXNIP
Human Protein Atlas	TXNIP
Associated Diseases	neuroinflammation
Interactions	Actin, AMPK, AND, APAF1, APOPTOSIS, ASC
KG Connections	258 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

txnip

gene · 2088 words

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Pathway Diagram

graph TD
    TXNIP["TXNIP"]
    PRKAA["PRKAA"]
    TXNIP -->|"interacts with"| PRKAA
    TXNIP -->|"regulates"| PRKAA
    autophagy(["autophagy"])
    TXNIP -->|"activates"| autophagy
    fatty_acid_oxidation(["fatty acid oxidation"])
    TXNIP -->|"activates"| fatty_acid_oxidation
    steatohepatitis{"steatohepatitis"}
    TXNIP -->|"protects against"| steatohepatitis
    Atherosclerosis{"Atherosclerosis"}
    TXNIP -->|"activates"| Atherosclerosis
    Stroke{"Stroke"}
    TXNIP -->|"activates"| Stroke
    Hepatitis{"Hepatitis"}
    TXNIP -->|"inhibits"| Hepatitis
    Diabetes{"Diabetes"}
    TXNIP -->|"therapeutic target"| Diabetes
    Fibrosis{"Fibrosis"}
    TXNIP -->|"activates"| Fibrosis
    Inflammation{"Inflammation"}
    TXNIP -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    TXNIP -->|"activates"| Neuroinflammation
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| TXNIP
    LC3B["LC3B"]
    LC3B -->|"activates"| TXNIP
    P62["P62"]
    P62 -->|"activates"| TXNIP
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"activates"| TXNIP
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| TXNIP
    STING["STING"]
    STING -->|"activates"| TXNIP
    GENES["GENES"]
    GENES -->|"activates"| TXNIP
    NRF2["NRF2"]
    NRF2 -->|"activates"| TXNIP
    CYLD["CYLD"]
    CYLD -->|"activates"| TXNIP
    APAF1["APAF1"]
    APAF1 -->|"activates"| TXNIP
    MTORC1["MTORC1"]
    MTORC1 -->|"activates"| TXNIP
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| TXNIP
    style TXNIP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (167)

Target	Relation	Type	Str
PRKAA	interacts_with	protein	0.90
PRKAA	regulates	protein	0.90
NLRP3	interacts_with	gene	0.90
steatohepatitis	protects_against	disease	0.90
autophagy	activates	pathway	0.90
fatty acid oxidation	activates	pathway	0.90
Inflammasome	activates	pathway	0.70
Diabetes	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Stroke	activates	disease	0.65
Ms	protects_against	disease	0.65
Atherosclerosis	activates	disease	0.65
Stroke	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Parkinson	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Parkinson	protects_against	disease	0.65
Hepatitis	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Tumor	inhibits	disease	0.65
Lymphoma	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Aging	activates	disease	0.65
Ischemia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Ferroptosis	regulates	disease	0.65
Als	activates	disease	0.65
Diabetes	contributes_to	disease	0.65
Stroke	inhibits	disease	0.65
Pyroptosis	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Necroptosis	inhibits	disease	0.65
Caspase	inhibits	protein	0.60
IL-1	activates	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Actin	activates	protein	0.60
Caspase	activates	protein	0.60
SQSTM1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NLRP3	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
AKT	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
RB1	protects_against	gene	0.60
NRF2	associated_with	gene	0.60

Incoming (91)

Source	Relation	Type	Str
ZFP36	downregulates	gene	0.95
ZFP36	binds	gene	0.95
ROS	activates	gene	0.80
NPAS3	regulates	gene	0.80
ROS	regulates	gene	0.70
ASC	expressed_in	gene	0.60
GSDMD	activates	gene	0.60
NLRP3	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
ATP13A2	regulates	gene	0.60
ZFP36	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
NF-ΚB	associated_with	gene	0.60
PARKINSON	protects_against	gene	0.60
HO-1	associated_with	gene	0.60
WNT	associated_with	gene	0.60
MYH9	activates	gene	0.60
HUB GENES	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
MIRNAS	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
MIR-155	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CCND1	activates	gene	0.60
BAK	inhibits	gene	0.60
AMPK	activates	gene	0.60
BAK	activates	gene	0.60
TLR	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
STING	activates	gene	0.60
NRF2	activates	gene	0.60
CYLD	activates	gene	0.60
TLR4	activates	gene	0.60
APAF1	activates	gene	0.60
IL7R	inhibits	gene	0.60
TBP	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
AXIN1	activates	gene	0.60
STAT3	activates	gene	0.60
RHEB	activates	gene	0.60
EGR1	activates	gene	0.60
HNF4A	activates	gene	0.60
MYC	activates	gene	0.60
YWHAZ	activates	gene	0.60
LC3B	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TXNIP in their description or question text

No additional research found