gene

CDKN1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

473Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

11Debates

Summary

Cell cycle regulator with critical roles in neuronal survival, DNA damage response, and neurodegeneration

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🧬 Gene Info

Gene Symbol	CDKN1A
Full Name	Cyclin-Dependent Kinase Inhibitor 1A
Chromosome	6p21.31
Function	is a key cell cycle regulator that mediates p53-dependent cell cycle arrest.
Amino Acids	164 aa
Pathways	TGF-β
UniProt ID	P38936
NCBI Gene ID	1026
Ensembl ID	ENSG00000100994
GeneCards	CDKN1A
Human Protein Atlas	CDKN1A
N-terminal domain	binds and inhibits CDK2/cyclin E and CDK1/cyclin B complexes
C-terminal domain	interacts with PCNA (proliferating cell nuclear antigen), blocking DNA replication
p53-binding region	contains p53-responsive elements for transcriptional activation
Neurons	particularly in post-mitotic differentiated neurons
Associated Diseases	Aging, Als, Alzheimer, Cancer, Cellular Senescence
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AGING, AGO2, AKT, AND, APOPTOSIS
SciDEX Hypotheses	p21-Targeted Proteolysis-Targeting Chimeras (PROTA
KG Connections	470 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDKN1A — AlphaFold P38936 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A

gene · 922 words

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Pathway Diagram

graph TD
    CDKN1A["CDKN1A"] -->|"regulates"| Senescence["Senescence"]
    CDKN1A["CDKN1A"] -->|"regulates"| Ms["Ms"]
    CDKN1A["CDKN1A"] -->|"regulates"| Autism["Autism"]
    CDKN1A["CDKN1A"] -->|"associated"| Als["Als"]
    CDKN1A["CDKN1A"] -->|"associated"| Ms_1["Ms"]
    CDKN1A["CDKN1A"] -->|"therapeutic target"| Ms_2["Ms"]
    CYCS["CYCS"] -.->|"inhibits"| CDKN1A["CDKN1A"]
    CD4["CD4"] -->|"interacts"| CDKN1A["CDKN1A"]
    MAPK3["MAPK3"] -->|"interacts"| CDKN1A["CDKN1A"]
    ZAP70["ZAP70"] -->|"interacts"| CDKN1A["CDKN1A"]
    style CDKN1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (295)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescent Cells	expressed_in	cell_type	0.95
SENESCENCE	associated_with	gene	0.90
Autophagosome	associated_with	cell_type	0.90
Cellular Senescence	associated_with	phenotype	0.90
Alzheimer'S Disease	therapeutic_target	disease	0.88
Proliferative Arrest	inhibits	process	0.85
Proliferative Arrest	causes	process	0.85
Pulmonary Vascular Endothelial Cell Senescence	biomarker_for	process	0.85
Senescence	biomarker_for	process	0.80
Cellular Senescence	biomarker_for	process	0.80
ROS	activates	gene	0.80
Cancer	activates	disease	0.75
Als	activates	disease	0.75
Senescence	regulates	disease	0.75
P21	inhibits	gene	0.70
CANCER	activates	gene	0.70
P62	regulates	gene	0.70
GENES	regulates	gene	0.70
p53 pathway	regulates	pathway	0.70
cellular senescence	biomarker_for	mechanism	0.70
Mapk	therapeutic_target	pathway	0.70
pericyte senescence	regulates	process	0.70
Senescence	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Ferroptosis	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Viral Infection	regulates	disease	0.65
Tumor	activates	disease	0.65
Spinal Muscular Atrophy	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Infection	regulates	disease	0.65
Prostate Cancer	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Dementia	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	regulates	disease	0.65

Incoming (178)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
SQSTM1	mediates	protein	0.95
Mir-302B	targets	biomarker	0.90
MIR-302B	targets	gene	0.90
XHP	upregulates	drug	0.90
Autophagy Deficiency	causes	phenotype	0.85
SIRT1	downregulates	protein	0.85
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.85
Xiyangshen Sanqi Danshen Granules	downregulates	drug	0.80
SQSTM1	binds_to	gene	0.80
telomere shortening	upregulates	phenotype	0.80
Srt2104	downregulates	drug	0.80
MIRNAS	regulates	gene	0.70
MAPK3	therapeutic_target	gene	0.70
P53	activates	gene	0.70
PRKCD	therapeutic_target	gene	0.60
H2AX	inhibits	gene	0.60
ATM	inhibits	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
BIRC5	therapeutic_target	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	regulates	gene	0.60
STAT3	associated_with	gene	0.60
KDM5A	associated_with	gene	0.60
TYRO3	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
CAMKK2	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
CCND1	regulates	gene	0.60
DUSP1	regulates	gene	0.60
RAF1	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
TIA1	activates	gene	0.60
AKT	activates	gene	0.60
CALCOCO2	activates	gene	0.60
ACTB	activates	gene	0.60
ATG5	activates	gene	0.60
BECN1	activates	gene	0.60
NPY1R	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
DNA	regulates	gene	0.60
ALS	expressed_in	gene	0.60