gene

AXIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

184Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AXIN1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 81 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AXIN1
Chromosome	16p13.3
Protein Type	Gene
Function	is a critical scaffolding protein that plays a central role in regulating the Wnt/beta-catenin signaling pathway.
Molecular Weight	86 kDa
Amino Acids	862 aa
Pathways	Wnt, Wnt signaling, Wnt pathway, Wnt Pathway
UniProt ID	O15169
NCBI Gene ID	351
Ensembl ID	ENSG00000102837
GeneCards	AXIN1
Human Protein Atlas	AXIN1
DIX domain (N-terminus)	Mediates self-oligomerization and interaction with Dishevelled proteins in the Wnt pathway.
Associated Diseases	neurodegeneration
Interactions	AKT, ALS, AMPK, AND, ATM, CANCER
KG Connections	184 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AXIN1 — AlphaFold O15169 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    AXIN1["AXIN1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Cancer["Cancer"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Als["Als"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Ms["Ms"]
    AXIN1["AXIN1"] -->|"therapeutic target"| PTGS2["PTGS2"]
    AXIN1["AXIN1"] -->|"regulates"| CREBBP["CREBBP"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Wnt["Wnt"]
    AXIN1["AXIN1"] -->|"regulates"| Epigenetic["Epigenetic"]
    AXIN1["AXIN1"] -->|"therapeutic target"| Notch["Notch"]
    style AXIN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style PTGS2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CREBBP fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Wnt fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Notch fill:#1b5e20,stroke:#333,color:#e0e0e0

Outgoing (132)

Target	Relation	Type	Str
CTNNB1	interacts_with	gene	0.85
Hepatocellular Carcinoma	suppresses	disease	0.75
CTNNB1	associated_with	gene	0.70
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Ms	inhibits	disease	0.65
SOCS3	activates	gene	0.60
RELA	activates	gene	0.60
SPI1	activates	gene	0.60
TBP	activates	gene	0.60
HNF4A	encodes	gene	0.60
RHEB	encodes	gene	0.60
SOCS3	encodes	gene	0.60
RELA	encodes	gene	0.60
EGR1	encodes	gene	0.60
SPI1	encodes	gene	0.60
TXNIP	encodes	gene	0.60
STAT3	encodes	gene	0.60
RUNX1	inhibits	gene	0.60
ALS	inhibits	gene	0.60
GLIOBLASTOMA	inhibits	gene	0.60
P53	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
WNT	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
AND	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
AND	activates	gene	0.60
RHEB	activates	gene	0.60
EGR1	activates	gene	0.60

Incoming (52)

Source	Relation	Type	Str
CDH1	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
CREBBP	regulates	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
STAT3	activates	gene	0.60
EGR1	activates	gene	0.60
TBP	activates	gene	0.60
RELA	activates	gene	0.60
RHEB	activates	gene	0.60
SPI1	activates	gene	0.60
HNF4A	activates	gene	0.60
HUB GENES	regulates	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	regulates	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MYH9	activates	gene	0.60
CCND1	activates	gene	0.60
MIRNAS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AXIN1 in their description or question text

No additional research found