gene

MYC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2227Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MYC is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 1388 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MYC
Chromosome	8q24.21
Function	is an important component in the neurobiology of neurodegenerative diseases.
Exons	3
Pathways	Akt, Amyloid, Angiogenesis, Apoptosis, Autophagy
Ensembl ID	ENSG00000136997
GeneCards	MYC
Human Protein Atlas	MYC
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	Bazhen Decoction, COENZYME Q10, LWDHD, MYC inhibitors, rapamycin, RAPAMYCIN
Interactions	66CTG peptide, ABCD1, ABCD2, ABL1, ACETYL-COA, ACHE
KG Connections	2227 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MYC Gene

gene · 759 words

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Pathway Diagram

graph TD
    MYC["MYC
(Central Gene)"]
    
    STAT3["STAT3"]
    PINK1["PINK1"]
    Cancer["Cancer"]
    Carcinoma["Carcinoma"]
    Lymphoma["Lymphoma"]
    Tumor["Tumor"]
    MetabolicSyndrome["Metabolic Syndrome"]
    Ms["Ms"]
    Als["Als"]
    Ischemia["Ischemia"]
    
    STAT3 -->|"regulates"| MYC
    MYC -->|"activates"| PINK1
    MYC -->|"activates"| Cancer
    MYC -->|"activates"| MetabolicSyndrome
    MYC -->|"activates"| Ms
    MYC -->|"activates"| Als
    MYC -->|"activates"| Tumor
    MYC -->|"regulates"| Ischemia
    MYC -->|"regulates"| Cancer
    MYC -->|"associated_with"| Cancer
    MYC -->|"associated_with"| Carcinoma
    MYC -->|"associated_with"| Lymphoma
    MYC -->|"associated_with"| Tumor
    MYC -->|"therapeutic_target"| Cancer
    
    style MYC fill:#ff6b6b,stroke:#c92a2a,stroke-width:3px,color:#e0e0e0,font-size:14px
    style Cancer fill:#ffd43b,stroke:#f59f00,stroke-width:2px
    style Tumor fill:#ffd43b,stroke:#f59f00,stroke-width:2px
    style Lymphoma fill:#ffd43b,stroke:#f59f00,stroke-width:2px
    style Carcinoma fill:#ffd43b,stroke:#f59f00,stroke-width:2px

Outgoing (1341)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Cancer	associated_with	disease	1.00
Cancer	expressed_in	disease	1.00
Mtor	activates	pathway	1.00
Tumor	associated_with	disease	1.00
Glycolysis	activates	pathway	1.00
Colorectal Cancer	activates	disease	1.00
Als	inhibits	disease	1.00
Als	regulates	disease	1.00
Tumor	activates	disease	1.00
Cancer	inhibits	disease	1.00
Als	activates	disease	1.00
Metastasis	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	regulates	disease	1.00
Aging	therapeutic_target	disease	1.00
Cancer	regulates	disease	1.00
Tumor	inhibits	disease	1.00
Carcinoma	activates	disease	1.00
Epigenetic	activates	pathway	1.00
MTOR	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
MTOR	therapeutic_target	gene	1.00
cancer progression	promotes	process	0.95
oncogenic gene expression	drives	process	0.95
RNA synthesis	elevates	process	0.95
iPSC Reprogramming	involved_in	process	0.95
Cancer	causes	disease	0.95
T cell proliferation	drives	process	0.95
Breast Cancer	activates	disease	0.95
cancer	associated_with	disease	0.95
Als	associated_with	disease	0.95
Tumor	expressed_in	disease	0.95
Lymphoma	associated_with	disease	0.95
cancer development and maintenance	promotes	process	0.95
uncontrolled cell proliferation	promotes	process	0.95
CD47	transcriptionally_regulates	gene	0.92
chemotherapy resistance	suppression_promotes	phenotype	0.92
IRF4	upregulates	gene	0.92
colorectal cancer	associated_with	disease	0.90
RNA decay	increases	process	0.90
PINK1	activates	gene	0.90
cell proliferation	promotes	process	0.90
Pluripotency	promotes	process	0.90
cancer cell growth	promotes	phenotype	0.90
CAR T CELL PROLIFERATION	activates	entity	0.90

Incoming (886)

Source	Relation	Type	Str
AKT	activates	gene	1.00
CANCER	activates	gene	1.00
CANCER	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
GENES	associated_with	gene	1.00
GENES	activates	gene	1.00
GENES	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
ERK	activates	gene	1.00
CANCER	inhibits	gene	1.00
P53	regulates	gene	1.00
GENES	inhibits	gene	1.00
CANCER	expressed_in	gene	1.00
HIF	activates	gene	1.00
STAT3	regulates	protein	0.98
IRF4	upregulates	gene	0.92
ERK	upstream_of	protein	0.90
H3Q5ser	regulates	phenotype	0.90
oncogenic lesions	activates	process	0.90
GENES	regulates	gene	0.90
CANCER	causes	gene	0.90
DNA	interacts_with	gene	0.90
PI3K	activates	gene	0.90
DNA	regulates	gene	0.90
ROS	activates	gene	0.90
PI3K	inhibits	gene	0.90
CANCER	regulates	gene	0.90
GENES	expressed_in	gene	0.90
TGM2	interacts_with	protein	0.88
SLC13A3	regulates	gene	0.85
Bazhen Decoction	modulates	drug	0.85
Wnt signaling pathway	regulates	pathway	0.85
MYC inhibitors	therapeutic_target	drug	0.85
NPC1	upstream_of	gene	0.85
SPOP	degrades	protein	0.85
PI3K/Akt Pathway	regulates	pathway	0.85
Pi3K/Akt Pathway	regulates	pathway	0.85
PI3K/AKT	regulates	pathway	0.85
BATF3	activates	gene	0.82
AKT1	upstream_of	gene	0.80
ERK	upregulates	protein	0.80
WNT Signaling	activates	pathway	0.80
AHCTF1	regulates	protein	0.80
NSD3	interacts_with	gene	0.80
Super-enhancer	upregulates	biological_process	0.80
APOPTOSIS	inhibits	gene	0.80
TP53	inhibits	gene	0.80
NF-ΚB	therapeutic_target	gene	0.80
YAP	activates	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti	0.540	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity