gene

SOCS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOCS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for SOCS3 - Suppressor of Cytokine Signaling 3

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🧬 Gene Info

Gene Symbol	SOCS3
Full Name	Suppressor of Cytokine Signaling 3
Aliases	Page for SOCS3
Chromosome	17q25.3
Function	encodes a key negative feedback regulator of the JAK-STAT signaling pathway, one of the primary intracellular signaling cascades mediating cytokine and growth factor responses.
Amino Acids	225 aa
Pathways	JAK-STAT signaling, jak-stat, NF-κB
Ensembl ID	ENSG00000184557
GeneCards	SOCS3
Human Protein Atlas	SOCS3
IL-10	Limits anti-inflammatory IL-10 signaling duration
Leptin receptor	Contributes to leptin resistance
G-CSF/EPO receptors	Regulates hematopoietic cytokine signaling
Aβ-driven inflammation	Amyloid-beta oligomers activate JAK-STAT3 signaling in microglia and astrocytes. Inadequate SOCS3 feedback allows sustained IL-6, TNF-α, and complement production
Associated Diseases	neurodegeneration
Interactions	Actin, AMPK, AND, APOPTOSIS, ATP, AUTOPHAGY
KG Connections	216 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SOCS3 - Suppressor of Cytokine Signaling 3

gene · 1237 words

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Pathway Diagram

graph TD
    SOCS3["SOCS3"]
    Inflammation{"Inflammation"}
    SOCS3 -->|"activates"| Inflammation
    Aging{"Aging"}
    SOCS3 -->|"activates"| Aging
    Ms{"Ms"}
    SOCS3 -->|"activates"| Ms
    Alzheimer{"Alzheimer"}
    SOCS3 -->|"therapeutic target"| Alzheimer
    Als{"Als"}
    SOCS3 -->|"therapeutic target"| Als
    SOCS3 -->|"therapeutic target"| Inflammation
    SOCS3 -->|"therapeutic target"| Ms
    SOCS3 -->|"regulates"| Aging
    SOCS3 -->|"regulates"| Ms
    TRPA1["TRPA1"]
    SOCS3 -->|"regulates"| TRPA1
    GENES["GENES"]
    SOCS3 -->|"regulates"| GENES
    CXCL2["CXCL2"]
    SOCS3 -->|"regulates"| CXCL2
    KLF14["KLF14"]
    KLF14 -->|"activates"| SOCS3
    PANX1["PANX1"]
    PANX1 -->|"regulates"| SOCS3
    S100B["S100B"]
    S100B -->|"regulates"| SOCS3
    RELB["RELB"]
    RELB -->|"regulates"| SOCS3
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| SOCS3
    CASP3["CASP3"]
    CASP3 -->|"regulates"| SOCS3
    ICAM1["ICAM1"]
    ICAM1 -->|"associated with"| SOCS3
    CXCL1["CXCL1"]
    CXCL1 -->|"associated with"| SOCS3
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"therapeutic target"| SOCS3
    AGING["AGING"]
    AGING -->|"regulates"| SOCS3
    style SOCS3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (136)

Target	Relation	Type	Str
IL6	inhibits	protein	0.85
Inflammation	activates	disease	0.75
STAT3	regulates	gene	0.70
STAT3	activates	gene	0.70
Cancer	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
TNF	activates	gene	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	activates	disease	0.65
NF-kB signaling	participates_in	pathway	0.65
Autoimmune	activates	disease	0.65
Aging	activates	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Lung Cancer	activates	disease	0.65
JAK-STAT signaling	participates_in	pathway	0.65
Ms	regulates	disease	0.65
Aging	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
AXIN1	activates	gene	0.60
neuroinflammation	activates	disease	0.60
HNF4A	activates	gene	0.60
YWHAZ	activates	gene	0.60
GENES	regulates	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60
TF	regulates	gene	0.60
SPI1	activates	gene	0.60
FUS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Nfkb	expressed_in	protein	0.60
RHEB	activates	gene	0.60
CCR6	activates	gene	0.60
IL-6	regulates	gene	0.60
Rb	activates	protein	0.60
STAT3	encodes	gene	0.60
RELA	activates	gene	0.60
TXNIP	encodes	gene	0.60
PCK1	therapeutic_target	gene	0.60
HSPB1	associated_with	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
OXIDATIVE STRESS	activates	gene	0.60
SPI1	encodes	gene	0.60
TBP	activates	gene	0.60
ERK1	activates	gene	0.60
IL-6	therapeutic_target	gene	0.60

Incoming (80)

Source	Relation	Type	Str
KLF14	activates	gene	0.80
IL30	upregulates	gene	0.80
IFN	inhibits	gene	0.70
IL6	upregulates	protein	0.70
IL-6	activates	gene	0.65
MIR-155	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CCND1	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MTDNA	activates	gene	0.60
COX2	activates	gene	0.60
ATP	activates	gene	0.60
LCN2	expressed_in	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
MYC	activates	gene	0.60
HUB GENES	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
MIRNAS	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
PCK1	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
HSPB1	associated_with	gene	0.60
STAT3	activates	gene	0.60
AXIN1	activates	gene	0.60
RHEB	activates	gene	0.60
EGR1	activates	gene	0.60
HNF4A	activates	gene	0.60
MYH9	activates	gene	0.60
YWHAZ	activates	gene	0.60
AXIN1	encodes	gene	0.60
HNF4A	encodes	gene	0.60
RHEB	encodes	gene	0.60
IFNI	activates	gene	0.60
CCND1	regulates	gene	0.60
MYH9	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
MIRNAS	encodes	gene	0.60
MYH9	encodes	gene	0.60
CCND1	encodes	gene	0.60
MCL1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SOCS3 in their description or question text

No additional research found