gene

APC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

603Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

APC is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 402 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	APC
Chromosome	5q22.2
Protein Type	Gene
Function	is a tumor suppressor gene originally identified for its role in colorectal cancer, but increasingly recognized for its critical functions in the central nervous system.
Amino Acids	843 aa
Pathways	Akt, Autophagy, Epigenetic, Mapk, Mtor
UniProt ID	P25054
NCBI Gene ID	324
Ensembl ID	ENSG00000134982
GeneCards	APC
Human Protein Atlas	APC
Oligomerization domain (N-terminus)	Allows APC to form homodimers and heterodimers, essential for its scaffold function.
Armadillo repeats	Mediate interactions with beta-catenin, B-catenin, and other proteins containing armadillo repeat domains.
15-amino acid repeats	Bind to beta-catenin with varying affinities. The SAMP repeats mediate beta-catenin degradation.
Basic domain	Binds to microtubules and regulates cytoskeletal dynamics.
Associated Diseases	Aging, Als, Cancer, Carcinoma, Colorectal Cancer, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ADNP, AKT, AKT1, AKT1S1, AND, APOPTOSIS
KG Connections	603 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APC — AlphaFold P25054 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    APC["APC"] -->|"regulates"| cancer["cancer"]
    APC["APC"] -->|"interacts"| Cancer["Cancer"]
    APC["APC"] -->|"interacts"| Als["Als"]
    APC["APC"] -->|"interacts"| Ms["Ms"]
    APC["APC"] -->|"regulates"| Fibrosis["Fibrosis"]
    APC["APC"] -->|"associated"| Cancer_1["Cancer"]
    OPTN["OPTN"] -->|"interacts"| APC["APC"]
    CASP3["CASP3"] -->|"regulates"| APC["APC"]
    AKT1["AKT1"] -->|"regulates"| APC["APC"]
    CALCOCO2["CALCOCO2"] -->|"regulates"| APC["APC"]
    style APC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (408)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.95
Cancer	activates	disease	0.95
CANCER	therapeutic_target	gene	0.90
CANCER	activates	gene	0.90
Als	therapeutic_target	disease	0.85
Tumor	inhibits	disease	0.85
Cancer	associated_with	disease	0.85
CANCER	associated_with	gene	0.80
Gastric Cancer	therapeutic_target	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Inflammation	activates	disease	0.75
Carcinoma	activates	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
cancer	regulates	disease	0.70
ATG	activates	gene	0.70
DNA	therapeutic_target	gene	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
glutamate signaling	participates_in	pathway	0.70
LC3	associated_with	gene	0.70
Wnt	activates	pathway	0.70
PIK3CA	associated_with	gene	0.70
PROTEOSTASIS	stabilizes	phenotype	0.70
GENES	inhibits	gene	0.70
Pancreatic Cancer	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Inflammation	expressed_in	disease	0.65
Carcinoma	regulates	disease	0.65
Infection	therapeutic_target	disease	0.65
Colorectal Cancer	activates	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	activates	disease	0.65
Tumor	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
PI3K	treats	gene	0.65
PI3K	targets	gene	0.65
Aging	associated_with	disease	0.65

Incoming (195)

Source	Relation	Type	Str
RAS	associated_with	gene	0.70
TP53	associated_with	gene	0.70
CDH1	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
CDH1	regulates	gene	0.70
KRAS	associated_with	gene	0.70
P53	inhibits	gene	0.70
RAS	causes	gene	0.60
WNT	associated_with	gene	0.60
CANCER	interacts_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
RAS	inhibits	gene	0.60
KRAS	causes	gene	0.60
AMPK	activates	entity	0.60
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	regulates	gene	0.60
ATF6	regulates	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
TCF4	associated_with	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Restore AQP4 Perivascular Polarization by Stabilizing DAPC/S	0.670	neurodegeneration	How can AQP4 be effectively targeted the

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APC in their description or question text

No additional research found

APC