gene

IRF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

265Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for IRF1 Gene - Interferon Regulatory Factor 1

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🧬 Gene Info

Gene Symbol	IRF1
Full Name	Interferon Regulatory Factor 1
Aliases	Page for IRF1 Gene, Page for IRF1 Protein
Chromosome	5q31.1.
Protein Type	Transcription Factor
Function	is a transcription factor encoded by the IRF1 gene located on chromosome 5q31.
Molecular Weight	36 kDa
Amino Acids	325 aa
Pathways	Autophagy, Cell Cycle, Complement, Immune Response, Immunotherapy
UniProt ID	P04855
NCBI Gene ID	3659
Ensembl ID	ENSG00000125347
OMIM	147575
GeneCards	IRF1
Human Protein Atlas	IRF1
Associated Diseases	Als, Inflammation, Ms, Neuroinflammation
Interactions	ACOD1, AND, APOPTOSIS, ATG5, ATXN3, AUTOPHAGY
KG Connections	265 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IRF1 — AlphaFold P04855 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IRF1 Gene - Interferon Regulatory Factor 1

gene · 779 words

→

IRF1 Protein - Interferon Regulatory Factor 1

protein · 796 words

→

Pathway Diagram

graph TD
    IRF1["IRF1"]
    IRF1 -->|"activates"| Cancer["Cancer"]
    IRF1 -->|"activates"| Ms["Ms"]
    IRF1 -->|"activates"| Tumor["Tumor"]
    IRF1 -->|"inhibits"| Als["Als"]
    IRF1 -->|"regulates"| Leukemia["Leukemia"]
    IRF1 -->|"regulates"| Lymphoma["Lymphoma"]
    NPM1["NPM1"] -->|"activates"| IRF1
    NLRC5["NLRC5"] -->|"activates"| IRF1
    CD8["CD8"] -->|"activates"| IRF1
    NDP52["NDP52"] -->|"inhibits"| IRF1
    CALCOCO2["CALCOCO2"] -->|"inhibits"| IRF1
    ATG5["ATG5"] -->|"inhibits"| IRF1
    ATG3["ATG3"] -->|"regulates"| IRF1
    CIITA["CIITA"] -->|"activates"| IRF1
    NFKB["NFKB"] -->|"inhibits"| IRF1
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| IRF1

Outgoing (136)

Target	Relation	Type	Str
ZBP1	regulates	protein	0.90
BST2	upregulates	protein	0.90
Cancer	activates	disease	0.85
Inflammation	activates	disease	0.85
NLRC5	binds	gene	0.80
CIITA	binds	gene	0.80
Type I Interferon-Like Gene Signature	mediates	phenotype	0.80
Tumor	activates	disease	0.75
Alzheimer	regulates	disease	0.75
Lymphoma	activates	disease	0.75
Autophagy	activates	pathway	0.70
Immune Response	regulates	pathway	0.70
Neuroinflammation	regulates	disease	0.65
ALS	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Leukemia	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Ms	regulates	disease	0.65
Infection	activates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Aging	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Autoimmune	activates	disease	0.65
Ms	interacts_with	disease	0.65
Als	activates	disease	0.65
Ischemia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
BST2	activates	protein	0.64
NPY1R	regulates	gene	0.60
cancer	activates	disease	0.60
Immune Response	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
Proteasome	inhibits	pathway	0.60
DNA	activates	gene	0.60
Oxidative Phosphorylation	inhibits	pathway	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
Complement	regulates	pathway	0.60
AND	activates	gene	0.60
ALS	associated_with	disease	0.60
T Cell	activates	cell_type	0.60
NDRG2	regulates	gene	0.60

Incoming (129)

Source	Relation	Type	Str
TNF-α	upstream_of	protein	0.90
NPM1	associated_with	protein	0.90
NPM1	interacts_with	protein	0.85
INFLAMMATION	activates	gene	0.80
ALZHEIMER'S DISEASE	regulates	gene	0.70
GENES	regulates	gene	0.70
CD8	activates	gene	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
STAT3	activates	gene	0.70
CALCOCO2	inhibits	gene	0.60
CIITA	activates	gene	0.60
PIK3C3	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
JAK3	inhibits	gene	0.60
HSPA1B	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
TNFAIP3	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
CD4	regulates	gene	0.60
REL	associated_with	gene	0.60
CD8	regulates	gene	0.60
STAT3	associated_with	gene	0.60
MFN1	activates	gene	0.60
PARKIN	activates	gene	0.60
ISG15	activates	gene	0.60
IL1B	interacts_with	gene	0.60
SOD2	interacts_with	gene	0.60
MARCKS	associated_with	gene	0.60
LAMP1	interacts_with	gene	0.60
MBP	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
S100A9	associated_with	gene	0.60
CCL5	activates	gene	0.60
IDO1	activates	gene	0.60
YY1	activates	gene	0.60
ATXN3	activates	gene	0.60
ATXN3	expressed_in	gene	0.60
CXCL10	causes	gene	0.60
NFKB	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
GENES	activates	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRF1 in their description or question text

No additional research found