concept

MYH9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYH9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MYH9
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APE2, AXIN1
Related Diseases	Alzheimer, Cardiovascular, ciliogenesis
Related Pathways	Amyloid

Pathway Diagram

graph TD
    MYH9["MYH9"]
    MYH9 -->|"interacts"| USP22["USP22"]
    MYH9 -->|"interacts"| LINC00599["LINC00599"]
    MYH9 -->|"inhibits"| ciliogenesis["ciliogenesis"]
    MYH9 -->|"involved_in"| Stress_Granule_Formation["Stress Granule Formation"]
    MYH9 -->|"activates"| Ms["Ms"]
    MYH9 -->|"activates"| Cardiovascular["Cardiovascular"]
    MYH9 -->|"activates"| Hypertension["Hypertension"]
    MYH9 -->|"regulates"| Alzheimer["Alzheimer"]
    Mt_125["Mt-125"] -->|"inhibits"| MYH9
    NEK9["NEK9"] -->|"interacts"| MYH9
    APE2["APE2"] -->|"binds"| MYH9
    LINC00599 -->|"interacts"| MYH9
    CK2["CK2"] -->|"phosphorylates"| MYH9
    G3BP1["G3BP1"] -->|"interacts"| MYH9

Outgoing (56)

Target	Relation	Type	Str
USP22	interacts_with	protein	0.92
LINC00599	interacts_with	gene	0.90
Stress Granule Formation	involved_in	process	0.80
ciliogenesis	inhibits	phenotype	0.80
Cardiovascular	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Hypertension	activates	disease	0.65
TBP	activates	gene	0.60
RELA	activates	gene	0.60
CCND1	activates	gene	0.60
RHEB	activates	gene	0.60
SPI1	activates	gene	0.60
MIRNAS	activates	gene	0.60
HNF4A	activates	gene	0.60
AXIN1	activates	gene	0.60
HUB GENES	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
MIR-155	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	activates	gene	0.60
MYC	activates	gene	0.60
YWHAZ	activates	gene	0.60
TXNIP	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
SOCS3	activates	gene	0.60
Amyloid	regulates	pathway	0.60
Myosin	regulates	protein	0.60
CCND1	encodes	gene	0.60
RHEB	encodes	gene	0.60
SOCS3	encodes	gene	0.60
RELA	encodes	gene	0.60
EGR1	encodes	gene	0.60
SPI1	encodes	gene	0.60
TXNIP	encodes	gene	0.60
STAT3	encodes	gene	0.60
Rb	activates	protein	0.60
RHEB	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TXNIP	regulates	gene	0.60
MYO1C	activates	gene	0.60
MYO1C	regulates	gene	0.60
TF	regulates	gene	0.60
PDGFRB	causes	gene	0.60
microglia	expressed_in	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
RNA	regulates	gene	0.60
AND	regulates	gene	0.60

Incoming (38)

Source	Relation	Type	Str
Mt-125	inhibits	drug	0.95
NEK9	interacts_with	protein	0.90
APE2	binds	gene	0.90
LINC00599	interacts_with	gene	0.90
CK2	phosphorylates	protein	0.87
G3BP1	interacts_with	protein	0.85
LINC00599	activates	gene	0.60
CCND1	activates	gene	0.60
G3BP1	activates	gene	0.60
LINC00599	regulates	gene	0.60
AND	regulates	gene	0.60
ZNF263	activates	gene	0.60
AXIN1	regulates	gene	0.60
CCND1	regulates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
HNF4A	encodes	gene	0.60
MIRNAS	encodes	gene	0.60
SPI1	activates	gene	0.60
RHEB	activates	gene	0.60
AXIN1	activates	gene	0.60
STAT3	activates	gene	0.60
MIRNAS	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HUB GENES	regulates	gene	0.60
TBP	activates	gene	0.60
HNF4A	activates	gene	0.60
RELA	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
EGR1	activates	gene	0.60
RNA	regulates	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
AXIN1	encodes	gene	0.60
AMYLOID	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MYH9 in their description or question text

No additional research found