gene

NDRG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDRG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NDRG2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with Als, Alzheimer, Dementia. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDRG2
Full Name	N-myc Downstream Regulated Gene 2
Chromosome	14q11.2
Protein Family	NDRG (N-myc downstream regulated) family
Function	is a member of the NDRG family (NDRG1-4) that functions as a stress-responsive differentiation marker.
Primary Expression	Brain, heart, kidney, skeletal muscle
Molecular Weight	43 kDa
Amino Acids	371 aa
Exons	16 exons
Pathways	Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle, Differentiation
UniProt ID	Q9ULL5
NCBI Gene ID	57412
Ensembl ID	ENSG00000112144
GeneCards	NDRG2
Human Protein Atlas	NDRG2
Associated Diseases	Alzheimer, Dementia, Depression, Diabetes, Glioma, Neurodegeneration
Interactions	ASTROCYTE, ASTROCYTES, CCND1, CDKN1A, C-JUN, COMPLEMENT
KG Connections	121 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDRG2 — AlphaFold Q9ULL5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDRG2 — N-myc Downstream Regulated Gene 2

gene · 1327 words

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Pathway Diagram

graph TD
    NDRG2["NDRG2"]
    Diabetes{"Diabetes"}
    NDRG2 -->|"associated with"| Diabetes
    Dementia{"Dementia"}
    NDRG2 -->|"inhibits"| Dementia
    EXERCISE["EXERCISE"]
    NDRG2 -->|"inhibits"| EXERCISE
    COMPLEMENT["COMPLEMENT"]
    NDRG2 -->|"activates"| COMPLEMENT
    AND["AND"]
    NDRG2 -->|"activates"| AND
    Nf__b(["Nf-Kappab"])
    NDRG2 -->|"activates"| Nf__b
    Complement(["Complement"])
    NDRG2 -->|"activates"| Complement
    Synaptic_Plasticity(["Synaptic Plasticity"])
    NDRG2 -->|"inhibits"| Synaptic_Plasticity
    neurodegeneration["neurodegeneration"]
    NDRG2 -->|"implicated in"| neurodegeneration
    NF__B["NF-KappaB"]
    NF__B -->|"activates"| NDRG2
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"inhibits"| NDRG2
    style NDRG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (69)

Target	Relation	Type	Str
MMP9	upregulates	gene	0.80
MYC	regulates	gene	0.70
Parkinson	regulates	disease	0.65
Als	inhibits	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Dementia	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Glioma	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Dementia	inhibits	disease	0.65
Ischemia	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Depression	regulates	disease	0.65
Differentiation	inhibits	pathway	0.60
Neurogenesis	activates	pathway	0.60
Differentiation	regulates	pathway	0.60
Nf-Κb	associated_with	pathway	0.60
EXERCISE	protects_against	gene	0.60
DEMENTIA	associated_with	gene	0.60
Neuron	protects_against	cell_type	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
CCND1	regulates	gene	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
SOX9	regulates	gene	0.60
MYH2	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
NPY1R	regulates	gene	0.60
SOX2	regulates	gene	0.60
MERTK	regulates	gene	0.60
IRF1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
LITAF	regulates	gene	0.60
Nfkb	regulates	protein	0.60
NLRP3	regulates	gene	0.60

Incoming (52)

Source	Relation	Type	Str
NF-ΚB	activates	gene	0.60
DEMENTIA	inhibits	gene	0.60
JUN	activates	gene	0.60
SOX9	regulates	gene	0.60
HDC	regulates	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	regulates	gene	0.60
NPY1R	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
MYH2	regulates	gene	0.60
CALM2	regulates	gene	0.60
MYC	regulates	gene	0.60
DLL1	regulates	gene	0.60
BACE1	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ASTROCYTES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
EXERCISE	protects_against	gene	0.60
DEMENTIA	associated_with	gene	0.60
NF-ΚB	associated_with	gene	0.60
CCND1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
C-JUN	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
GENES	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
TSC22D3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDRG2 in their description or question text

No additional research found