pathway

WNT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3046Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	WNT
Key Genes/Proteins	AB, ACHE, ACSL5, Actin, ACVR2A, AD
Related Diseases	aging, Aging
Related Pathways	Akt
Linked Hypotheses	1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WNT["WNT"] -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    WNT["WNT"] -->|"activates"| Carcinoma["Carcinoma"]
    WNT["WNT"] -->|"expressed in"| Cancer["Cancer"]
    WNT["WNT"] -->|"expressed in"| Tumor["Tumor"]
    WNT["WNT"] -->|"contributes to"| Tumor_1["Tumor"]
    WNT["WNT"] -->|"contributes to"| Cancer_2["Cancer"]
    FZD3["FZD3"] -->|"participates in"| WNT["WNT"]
    FZD3_3["FZD3"] -->|"binds"| WNT["WNT"]
    PSMB1["PSMB1"] -->|"activates"| WNT["WNT"]
    BECN1["BECN1"] -->|"activates"| WNT["WNT"]
    style WNT fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1050)

Target	Relation	Type	Str
neurogenesis	regulates	process	0.95
synaptic plasticity	regulates	process	0.95
Synapse Remodeling	regulates	process	0.90
Neurodevelopment	involved_in	process	0.90
Autophagy	interacts_with	process	0.90
PFKM	downregulates	protein	0.90
neuroinflammation	regulates	process	0.90
Wnt/β-catenin signaling	part_of	pathway	0.90
beta-catenin	regulates	protein	0.90
Autophagy	interacts_with	process	0.85
autophagy	suppresses	process	0.85
Amyotrophic Lateral Sclerosis	protects_against	disease	0.85
Parkinson's Disease	protects_against	disease	0.85
stroke	protects_against	disease	0.85
Alzheimer's Disease	protects_against	disease	0.85
vascular remodeling	modulates	process	0.85
PI3K/AKT	interacts_with	pathway	0.80
Hepatocellular Carcinoma	causes	disease	0.80
NF-κB	interacts_with	pathway	0.80
autophagy	mediates	process	0.80
BMP	interacts_with	pathway	0.80
TGF-β	interacts_with	pathway	0.80
endothelial cells	expressed_in	cell_type	0.80
Autism-Like Behaviors	mediates	phenotype	0.80
Pulmonary Arterial Hypertension	associated_with	disease	0.80
Wnt3	part_of	protein	0.80
Wnt signaling	participates_in	pathway	0.80
Alzheimer's disease	associated_with	disease	0.80
β-catenin	interacts_with	protein	0.80
embryo development	modulates	process	0.75
PULMONARY HYPERTENSION	involved_in	entity	0.75
Pulmonary Arterial Hypertension	involved_in	disease	0.75
glioblastoma	activates	disease	0.70
neural stem cells	activates	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
GBM	associated_with	disease	0.70
glioblastoma multiforme	regulates	disease	0.70
GSK-3β	regulates	protein	0.70
oxidative stress response	participates_in	pathway	0.70
TMJOA	associated_with	disease	0.70
CI-994	modulates	drug	0.70
DKK1	inhibits	protein	0.70
β-catenin	inhibits	protein	0.70
autophagy pathway	participates_in	pathway	0.70
Als	protects_against	disease	0.65
Cardiovascular	protects_against	disease	0.65
Tumor	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	protects_against	disease	0.65

Incoming (1996)

Source	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
EGFR	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
PI3K	associated_with	gene	1.00
Als	activates	disease	1.00
Tumor	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
AKT	therapeutic_target	gene	1.00
CANCER	associated_with	gene	1.00
MTOR	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
CANCER	therapeutic_target	gene	1.00
PI3K	activates	gene	1.00
AKT	activates	gene	1.00
GENES	activates	gene	1.00
Cancer	activates	disease	1.00
AKT	associated_with	gene	1.00
CANCER	activates	gene	1.00
Als	regulates	disease	1.00
MTOR	associated_with	gene	1.00
Carcinoma	therapeutic_target	disease	1.00
Carcinoma	activates	disease	1.00
P53	associated_with	gene	1.00
P53	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
AKT	regulates	gene	1.00
CANCER	regulates	gene	1.00
AMYLOID	associated_with	protein	0.98
Cancer	regulates	disease	0.95
CTNNB1	involved_in	gene	0.95
Bnt162B2	associated_with	drug	0.95
DKK1	inhibits	gene	0.90
Thermal adaptation	inhibits	process	0.90
OXIDATIVE STRESS	activates	gene	0.90
PI3K	regulates	gene	0.90
APOPTOSIS	regulates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
Colorectal Cancer	activates	disease	0.90
ROS	activates	gene	0.90
INFLAMMATION	therapeutic_target	gene	0.90
GENES	therapeutic_target	gene	0.90
NF-ΚB	activates	gene	0.90
BNT162b2	modulates	drug	0.85
Microglia	activates	cell_type	0.85
DVL3	regulates	gene	0.85
SFRP1	inhibits	gene	0.85
NOTUM	inhibits	gene	0.85

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Wnt/β-catenin Pathway Restoration	0.686	-	Blood-brain barrier tight junction disru
Inhibitory Neuron-Selective WNT Signaling Restoration	0.554	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT in their description or question text

No additional research found

WNT

Understanding Entity Pages

Wiki Pages (21)

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

WNT4 Gene

WNT7A Gene

WNT2B Gene - Wnt Family Member 2B

WNT3 Gene

WNT10A Gene

WNT5B Gene

WNT7B Gene - Wnt Family Member 7B

DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1

WNT11 Gene

WNT8A Gene

WNT9B Gene

WNT1 Gene

WNT1 Protein

WNT9A — Wnt Family Member 9A

WNT6 — Wnt Family Member 6

WNT2 Gene

WNT2 Protein

AD WNT Signaling and Developmental Pathway Companies

WNT3A Gene

WNT8B Gene