gene

CTNNB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTNNB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

498Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CTNNB1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with ALS, Aging, Als. Connected to 334 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTNNB1
Full Name	Catenin Beta 1
Chromosome	3p22.1
Primary Expression	Ubiquitous, highest in brain
Molecular Weight	85 kDa
Amino Acids	781 aa
Pathways	Wnt signaling, Wnt, Wnt pathway
UniProt ID	P35222
NCBI Gene ID	1499
Ensembl ID	ENSG00000100994
OMIM	116806
GeneCards	CTNNB1
Human Protein Atlas	CTNNB1
Associated Diseases	Als, Alzheimer, Blood-Brain Barrier Integrity, Breast Cancer, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	ABCD1, ABCD2, ABCD3, ACVR2A, AKT, AKT1
SciDEX Hypotheses	Wnt/β-catenin Pathway Restoration
KG Connections	498 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTNNB1 — AlphaFold P35222 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CTNNB1 — Catenin Beta 1

gene · 2340 words

→

CTNNB1 Protein

protein · 1001 words

→

Pathway Diagram

flowchart TD
    CTNNB1_gene["CTNNB1
Gene"]
    beta_catenin["beta-Catenin
Protein"]
    LRP1["LRP1
Receptor"]
    TCF3["TCF3
Transcription Factor"]
    AXIN2["AXIN2
Wnt Regulator"]
    RRM1["RRM1
DNA Repair"]
    SQSTM1["SQSTM1/p62
Autophagy Adapter"]
    RAB7A["RAB7A
Vesicle Transport"]
    
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    MS["Multiple Sclerosis
(MS)"]
    neuroinflammation["Neuroinflammation"]
    fibrosis["Tissue Fibrosis"]
    cancer["Cancer/Tumors"]
    
    wnt_signaling["Wnt Signaling
Pathway"]
    cell_adhesion["Cell Adhesion
 and Migration"]
    synaptic_function["Synaptic Function
 and Plasticity"]
    
    CTNNB1_gene -->|"encodes"| beta_catenin
    LRP1 -->|"regulates"| beta_catenin
    beta_catenin -->|"interacts_with"| TCF3
    beta_catenin -->|"activates"| wnt_signaling
    beta_catenin -->|"regulates"| cell_adhesion
    beta_catenin -->|"modulates"| synaptic_function
    
    wnt_signaling -->|"associated_with"| AXIN2
    beta_catenin -->|"activates"| RRM1
    CTNNB1_gene -->|"associated_with"| SQSTM1
    CTNNB1_gene -->|"associated_with"| RAB7A
    
    CTNNB1_gene -->|"regulates"| ALS
    CTNNB1_gene -->|"therapeutic_target"| MS
    CTNNB1_gene -->|"therapeutic_target"| neuroinflammation
    CTNNB1_gene -->|"therapeutic_target"| fibrosis
    CTNNB1_gene -->|"regulates"| cancer
    
    wnt_signaling -->|"dysfunction_leads_to"| ALS
    cell_adhesion -->|"impairment_causes"| neuroinflammation
    synaptic_function -->|"disruption_in"| MS
    
    style beta_catenin fill:#006494
    style wnt_signaling fill:#1b5e20
    style cell_adhesion fill:#1b5e20
    style synaptic_function fill:#1b5e20
    style TCF3 fill:#4a1a6b
    style AXIN2 fill:#4a1a6b
    style LRP1 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style neuroinflammation fill:#ef5350
    style cancer fill:#5d4400
    style fibrosis fill:#5d4400

Outgoing (334)

Target	Relation	Type	Str
TJP1	interacts_with_confidence_0.969	gene	0.97
SLC13A3	upstream_of	gene	0.95
WNT	involved_in	pathway	0.95
liver cancer	risk_factor_for	disease	0.94
Hippocampal Neurogenesis	involved_in	process	0.90
Autophagy	interacts_with	process	0.90
Cancer	associated_with	disease	0.85
Hepatocellular Carcinoma	biomarker_for	disease	0.85
TSPAN1	interacts_with	gene	0.80
Capillary Endothelial Cells	expressed_in	cell_type	0.80
Blood-Brain Barrier Integrity	associated_with	phenotype	0.80
GLUTAMINESYNTHETASE	upregulates	enzyme	0.80
Hepatocellular Carcinoma	associated_with	disease	0.80
cancer	regulates	disease	0.80
OCLN	interacts_with_confidence_0.775	gene	0.78
Hepatocellular Carcinoma	activates	disease	0.75
Carcinoma	activates	disease	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Tumor	associated_with	disease	0.75
Cancer	regulates	disease	0.75
Carcinoma	associated_with	disease	0.75
Cancer	activates	disease	0.75
Als	regulates	disease	0.75
Wnt/TGF-β Proliferation Pathway	involved_in	pathway	0.75
beta-catenin	encodes	protein	0.72
RRM1	activates	gene	0.72
CANCER	expressed_in	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Wnt	activates	pathway	0.70
Tumor	regulates	disease	0.65
Schizophrenia	activates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Lupus	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Depression	activates	disease	0.65
Hepatitis	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	expressed_in	disease	0.65

Incoming (164)

Source	Relation	Type	Str
h-eef1be45	targets	hypothesis	0.90
AXIN1	interacts_with	gene	0.85
CRTH2	modulates	receptor	0.85
CRTH2	regulates	receptor	0.85
TDP43	regulates	protein	0.85
FZD3	activates	gene	0.80
LMP2	inhibits	protein	0.80
KRAS	associated_with	gene	0.70
CANCER	associated_with	gene	0.70
GENES	associated_with	gene	0.70
ARID1A	associated_with	gene	0.70
CANCER	activates	gene	0.70
TP53	associated_with	gene	0.70
AXIN1	associated_with	gene	0.70
NFKB1	associated_with	gene	0.69
AUTOPHAGY	regulates	phenotype	0.65
LRP1	regulates	protein	0.64
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TP53	activates	gene	0.60
TERT	activates	gene	0.60
ACVR2A	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
P62	activates	gene	0.60
GAPDH	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
TP53	expressed_in	gene	0.60
TNF	regulates	gene	0.60
PI3K	regulates	gene	0.60
EZH2	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
GSK3B	interacts_with	gene	0.60
AKT	regulates	gene	0.60
EED	regulates	gene	0.60
PTEN	associated_with	gene	0.60
GAIN	implicated_in	gene	0.60
CD8	therapeutic_target	gene	0.60
MMP9	implicated_in	gene	0.60
AMPK	activates	entity	0.60
TCF4	associated_with	gene	0.60
MYC	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Wnt/β-catenin Pathway Restoration	0.686	-	Blood-brain barrier tight junction disru

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

closed · Rounds: 4 · Score: 0.76 · 2026-04-23

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

closed · Rounds: 7 · Score: 0.87 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CTNNB1 in their description or question text

No additional research found