gene

CYCLIN D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYCLIN D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

235Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	CYCLIN D1
Pathways	Autophagy, Wnt, Mtor, Metastasis, Cell Cycle
Associated Diseases	Cancer, Carcinoma
Interactions	AKT, AMBRA1, AMPK, AND, APOPTOSIS, ATM
KG Connections	230 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| Tumor["Tumor"]
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| Cancer["Cancer"]
    CYCLIN_D1["CYCLIN D1"] -->|"expressed in"| Cancer_1["Cancer"]
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| CANCER["CANCER"]
    CYCLIN_D1["CYCLIN D1"] -->|"expressed in"| GENES["GENES"]
    CYCLIN_D1["CYCLIN D1"] -->|"activates"| ALS["ALS"]
    STAT3["STAT3"] -->|"activates"| CYCLIN_D1["CYCLIN D1"]
    MTOR["MTOR"] -->|"associated"| CYCLIN_D1["CYCLIN D1"]
    P62["P62"] -->|"activates"| CYCLIN_D1["CYCLIN D1"]
    MYC["MYC"] -->|"associated"| CYCLIN_D1["CYCLIN D1"]
    style CYCLIN_D1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (128)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CYCLIN D1	data_in	dataset_row	0.00
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Cancer	expressed_in	disease	0.75
GENES	expressed_in	gene	0.70
CANCER	activates	gene	0.70
Als	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	activates	disease	0.65
Tumor	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Carcinoma	expressed_in	disease	0.65
Hepatocellular Carcinoma	expressed_in	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Glioblastoma	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Als	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ataxia	activates	disease	0.65
Cancer	associated_with	disease	0.65
MYC	associated_with	gene	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
AKT	activates	gene	0.60
P53	activates	gene	0.60
CANCER	associated_with	gene	0.60
EGF	expressed_in	gene	0.60
P21	expressed_in	gene	0.60
Cell Cycle	expressed_in	pathway	0.60
Wnt	regulates	pathway	0.60
NFKBIE	therapeutic_target	gene	0.60
CDKN2A	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
Epigenetic	activates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
P53	expressed_in	gene	0.60
Glycolysis	activates	pathway	0.60
SMAD4	expressed_in	gene	0.60

Incoming (107)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CYCLIN D1	data_in	dataset_row	0.00
STAT3	activates	gene	0.70
RB1	regulates	gene	0.70
31745295	inhibit	paper	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
31745295	inhibited	paper	0.60
RNA	activates	gene	0.60
LNCRNA	activates	gene	0.60
CDKN2B-AS1	activates	gene	0.60
NATURAL COMPOUNDS	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
DDB1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
AND	regulates	gene	0.60
MIRNAS	activates	gene	0.60
C-MYC	activates	gene	0.60
VIMENTIN	activates	gene	0.60
WNT	activates	gene	0.60
TCF4	activates	gene	0.60
GENES	activates	gene	0.60
FOXP3	activates	gene	0.60
CANCER	activates	gene	0.60
CCND1	activates	gene	0.60
SRC	activates	gene	0.60
EGFR	activates	gene	0.60
HDAC3	activates	gene	0.60
EGF	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC6	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
HDAC1	inhibits	gene	0.60
ROS	inhibits	gene	0.60
AND	activates	gene	0.60
P62	activates	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYCLIN D1 in their description or question text

No additional research found