gene

PPP5C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP5C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

36Outgoing

26Incoming

0Experiments

0Debates

Summary

PPP5C encodes PP5, a serine/threonine phosphatase critical for glucocorticoid signaling, tau dephosphorylation, Hsp90 regulation, and stress response. Dysregulation contributes to Alzheimer's disease, Parkinson's disease, and cancer.

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🧬 Gene Info

Gene Symbol	PPP5C
Full Name	Protein Phosphatase 5 Catalytic Subunit
Protein Family	Serine/Threonine Phosphatase Family
Protein Type	Serine/Threonine Phosphatase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various cancers - Cell Proliferation: Promotes cell cycle progression - Therapeutic Target: PP5 inhibitors are being explored as cancer therap
Subcellular Localization	Cytoplasm, Nucleus
Molecular Weight	57 kDa
Amino Acids	589 aa
Pathways	MAPK
UniProt ID	[P62937](https://www.uniprot.org/uniprot/P62937)
Ensembl ID	ENSG00000111454
GeneCards	PPP5C
Human Protein Atlas	PPP5C
N-terminal TPR domain	Contains multiple TPR motifs that mediate protein interactions
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	CCND1, CDKN1A, DUSP1, HSP90, NDRG2, SESN1
KG Connections	62 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PPP5C — Protein Phosphatase 5 Catalytic Subunit

gene · 3006 words

→

PPP5C Protein

protein · 773 words

→

Pathway Diagram

graph TD
    PPP5C["PPP5C"]
    JUN["JUN"]
    ADRA1D["ADRA1D"]
    PDK4["PDK4"]
    LITAF["LITAF"]
    IL6R["IL6R"]
    CCND1["CCND1"]
    MERTK["MERTK"]
    DUSP1["DUSP1"]
    ADCY9["ADCY9"]
    AUTOPHAGY["AUTOPHAGY"]
    SOX2["SOX2"]
    CDKN1A["CDKN1A"]
    SESN1["SESN1"]
    IRF1["IRF1"]
    NDRG2["NDRG2"]
    SOX9["SOX9"]
    MYH2["MYH2"]
    VPS37B["VPS37B"]
    MTORC1["MTORC1"]
    NFKBIA["NFKBIA"]
    PPP5C -->|"regulates"| JUN
    PPP5C -->|"regulates"| ADRA1D
    PPP5C -->|"regulates"| PDK4
    PPP5C -->|"regulates"| LITAF
    PPP5C -->|"regulates"| IL6R
    PPP5C -->|"regulates"| CCND1
    PPP5C -->|"regulates"| MERTK
    PPP5C -->|"regulates"| DUSP1
    PPP5C -->|"regulates"| ADCY9
    PPP5C -->|"regulates"| AUTOPHAGY
    PPP5C -->|"regulates"| SOX2
    PPP5C -->|"regulates"| CDKN1A
    PPP5C -->|"regulates"| SESN1
    PPP5C -->|"regulates"| IRF1
    PPP5C -->|"regulates"| NDRG2
    PPP5C -->|"regulates"| SOX9
    PPP5C -->|"regulates"| MYH2
    PPP5C -->|"regulates"| VPS37B
    PPP5C -->|"regulates"| MTORC1
    PPP5C -->|"regulates"| NFKBIA
    style PPP5C fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (36)

Target	Relation	Type	Str
Nfkb	regulates	protein	0.60
NPY1R	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
Actin	regulates	protein	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	regulates	gene	0.60
NDRG2	regulates	gene	0.60
SOX9	regulates	gene	0.60
MYH2	regulates	gene	0.60
CCND1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
TPR	activates	gene	0.55
tauopathy	activates	disease	0.55
CELL CYCLE	interacts_with	cell_type	0.50
MTORC1	interacts_with	concept	0.50
CCND1	interacts_with	protein	0.50

Incoming (26)

Source	Relation	Type	Str
CCND1	regulates	gene	0.60
NPY1R	regulates	gene	0.60
MERTK	regulates	gene	0.60
CALM2	regulates	gene	0.60
VPS37B	regulates	gene	0.60
PDK4	regulates	gene	0.60
DUSP1	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
SOX9	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
JUN	regulates	gene	0.60
SESN1	regulates	gene	0.60
MYH2	regulates	gene	0.60
SOX2	regulates	gene	0.60
MTORC1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
HDC	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
IL6R	regulates	gene	0.60
ADCY9	regulates	gene	0.60
HSP90	activates	gene	0.55
SESN1	interacts_with	gene	0.50
CDKN1A	interacts_with	gene	0.50
NDRG2	interacts_with	gene	0.50
DUSP1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP5C in their description or question text

No additional research found