gene

DUSP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

Dual Specificity Phosphatase 1 - negative regulator of MAPK signaling in neurons

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🧬 Gene Info

Gene Symbol	DUSP1
Full Name	Dual Specificity Phosphatase 1
Chromosome	5q33.1
Protein Type	Phosphatase
Function	is a critical negative regulator of MAPK signaling that dephosphorylates and inactivates MAPK family members including ERK, JNK, and p38[@avraham2022].
Molecular Weight	40 kDa
Amino Acids	367 aa
Pathways	MAPK signaling, MAPK, MAPK pathway
UniProt ID	[P28562](https://www.uniprot.org/uniprot/P28562)
Ensembl ID	ENSG00000120129
OMIM	603067
GeneCards	DUSP1
Human Protein Atlas	DUSP1
ERK1/2 dephosphorylation	Inactivates ERK1/2 signaling, terminating proliferation and differentiation signals
JNK dephosphorylation	Reduces stress-activated pro-apoptotic signaling
Associated Diseases	Encephalitis, Fibrosis, Ms, Multiple Sclerosis, Myeloma, Tumor
Interactions	AND, App, BAX, CCND1, CDKN1A, CGAS
KG Connections	127 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DUSP1["DUSP1"]
    Neuroinflammation{"Neuroinflammation"}
    DUSP1 -->|"inhibits"| Neuroinflammation
    Ms{"Ms"}
    DUSP1 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    DUSP1 -->|"inhibits"| Inflammation
    DUSP1 -->|"associated with"| Ms
    Tumor{"Tumor"}
    DUSP1 -->|"associated with"| Tumor
    Als{"Als"}
    DUSP1 -->|"activates"| Als
    Spinal_Cord_Injury{"Spinal Cord Injury"}
    DUSP1 -->|"inhibits"| Spinal_Cord_Injury
    MAPK(["MAPK"])
    DUSP1 -->|"inhibits"| MAPK
    Pyroptosis(["Pyroptosis"])
    DUSP1 -->|"inhibits"| Pyroptosis
    Mapk(["Mapk"])
    DUSP1 -->|"inhibits"| Mapk
    HSPA1A["HSPA1A"]
    DUSP1 -->|"inhibits"| HSPA1A
    Chaperone(["Chaperone"])
    DUSP1 -->|"inhibits"| Chaperone
    HSPA1A -->|"interacts with"| DUSP1
    HSPA1A -->|"inhibits"| DUSP1
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"inhibits"| DUSP1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| DUSP1
    MAPK3["MAPK3"]
    MAPK3 -->|"activates"| DUSP1
    MAPK1["MAPK1"]
    MAPK1 -->|"activates"| DUSP1
    MYC["MYC"]
    MYC -->|"expressed in"| DUSP1
    AND["AND"]
    AND -->|"inhibits"| DUSP1
    style DUSP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (89)

Target	Relation	Type	Str
MAPK Signaling Pathway	inhibits	pathway	0.90
Tumor	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Encephalitis	associated_with	disease	0.65
Spinal Cord Injury	inhibits	disease	0.65
Als	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
MAPK	inhibits	pathway	0.64
Toll-Like Receptor	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
App	activates	protein	0.60
Actin	regulates	protein	0.60
pyroptosis	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
pyroptosis	activates	process	0.60
HSPA1A	inhibits	gene	0.60
DUSP6	activates	gene	0.60
ERK1	activates	gene	0.60
ERK2	activates	gene	0.60
MIRO1	activates	gene	0.60
LITAF	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
CCND1	regulates	gene	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
Nf-Κb	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Nfkb	regulates	protein	0.60
Pyroptosis	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Chaperone	inhibits	pathway	0.60
INFLAMMATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
Mapk	activates	pathway	0.60
MICROGLIA	activates	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
Chaperone	activates	pathway	0.60
CGAS-STING	activates	gene	0.60
DNA	protects_against	gene	0.60

Incoming (38)

Source	Relation	Type	Str
HSPA1A	upregulates	protein	0.85
HSPA1A	interacts_with	gene	0.64
VPS37B	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
AND	activates	gene	0.60
CGAS	activates	gene	0.60
BAX	activates	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
ADCY9	regulates	gene	0.60
NPY1R	regulates	gene	0.60
CALM2	regulates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MTDNA	protects_against	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
CCND1	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
MTORC1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
HSPA1A	inhibits	gene	0.60
MAPK3	activates	gene	0.60
MAPK1	activates	gene	0.60
MYC	expressed_in	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
NDRG2	interacts_with	gene	0.50
SESN1	interacts_with	gene	0.50
CDKN1A	interacts_with	gene	0.50
Neuroinflammation	inhibits	process	0.50
HSPA1A	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DUSP1 in their description or question text

No additional research found